Elaboration of a high-throughput toolbox for analysis and visualization of mesoscale longitudinal cortical imaging dataset

In recent years, a dramatic increase in computer processing power and storage allowed the exploration of new frontiers in science by analyzing large, complex datasets. The field of neuroscience is evolving towards larger and more complex studies creating a huge amount of data that is hard to understand using classical analyses. Thus, the development of […]

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Elaboration of a high-throughput toolbox for analysis and visualization of mesoscale longitudinal cortical imaging dataset – Year two

In recent years, a dramatic increase in computer processing power and storage allowed the exploration of new frontiers in science by analyzing large, complex datasets. The field of neuroscience is evolving towards larger and more complex studies creating a huge amount of data that is hard to understand using classical analyses. Thus, the development of […]

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Trunk task-oriented training combined with functional electrical stimulation to improve functional independence in spinal cord injured individuals

Following a spinal cord injury (SCI), sensory and motor impairments affect the ability to perform daily life tasks independently, such as transferring or grabbing an object. Intuitively to accomplish these tasks, the use of the upper and lower limbs is obvious, but the trunk is equally essential. Trunk control alterations generate deficits in the functional […]

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Development of a multiplexed mass spectrometry assay for the detection and quantification of organ toxicity biomarkers during preclinical drug safety assessments

In recent years, the interest given to disease biomarkers has boomed. Biotechnology and pharmaceutical companies are exploring ways to use biomarkers to speed up the drug development process, as well as to rapidly assess a diseases state, staging, progression and response to therapy. Multiple reaction monitoring (MRM) Mass Spectrometry (MS) has been shown to be […]

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Development of biomarkers to assess health impact of exposure to algal toxins in Atlantic salmon (Salmo salar) and effectiveness of mitigation measures at marine open-pen salmon farms

Atlantic salmon are Canada’s top aquaculture export and contribute $1.5 billion annually to British Columbia’s (BC) economy. In BC, blooms of toxic algae are a common problem for salmon farmers, often resulting in large production losses due to lost growth and disease with high mortality. I recently identified for the first time at BC fish […]

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IMMUNONUTRITION FOR HEALTH AND PRODUCTION IN PIGS AND BROILERS

The reduction of antibiotic use in livestock as an emerging public health response, as well as the continued increase in the global need for animal-based proteins, requires holistic approaches to address these current challenges in animal production. Immunonutrition is a promising field that allows modulate immune system responses through interventions with specific nutrients that have […]

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IMMUNONUTRITION FOR HEALTH AND PRODUCTION IN PIGS AND BROILERS – Year two

The reduction of antibiotic use in livestock as an emerging public health response, as well as the continued increase in the global need for animal-based proteins, requires holistic approaches to address these current challenges in animal production. Immunonutrition is a promising field that allows modulate immune system responses through interventions with specific nutrients that have […]

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Development of Pharmacological Probes for Road-Mapping WD40 Domain Proteins

Since the dawn of the human genome sequencing in 2003, great hopes have been put into the development of new therapeutics and personalized medicine tailored on individual DNA profiles. Nonetheless, progress in these fields has been slow, mainly due to the focus of the research community on only a small number of genes and proteins […]

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The application and validation of predictive models to establish indices of protein quality in companion animal feed ingredients

This project will result in the generation of mathematical models that will predict the quality and sustainability of protein-based ingredients that are commonly used in dog diets. With the projected growth of human and pet populations, and increases in food production necessary to meet growing demands, providing Canadian pet food companies (such as our industry […]

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Techna Guided Therapeutics Cluster

The Guided Therapeutics (GTx) Core of the Techna Institute is developing innovative imaging technology and therapeutic approaches, and translating those advances to commercial and clinical applications. Working with our industrial partners Precision X-Ray and Elekta, the Mitacs-supported interns will develop new capabilities and tools for preclinical image-guided radiation therapy devices and radiosurgical techniques. With Precision […]

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Structural modeling for glycosaminoglycan/peptide complexes

Glycosaminoglycans (GAGs) are biological anchors for growth factors (GF) and other chemical substances. The binding of these substances to GAGs can be modified in times of need. For example during wound healing the increased number of GAGs in the injured areas enables a very localized increase in growth factors and chemokines necessary for wound healing. […]

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Metabolic Lipid Abnormalities in Prediabetes and Insulin Resistance

Type 2 diabetes is characterized by insulin resistance and has been associated with increased lipids (fat) in the blood (hyperlipidemia). Our research focuses on regulation of blood lipid levels by controlling both intestinal and liver fat (lipid/lipoprotein) metabolism. We have previously shown in our laboratory that a naturally occurring hormone called glucagon-like peptide-1 (GLP-1) can […]

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