Cyclin-dependent kinase-2 (CDK2) regulates cell cycle, whose structure and biological characteristics are well known. CRIF1 plays a regulatory role in the bone marrow microenvironment-induced leukemia cell cycle arrest through inhibiting CDK2. In this multi-disciplinary research, we will use a combined structure function study to reveal the interaction between CDK2 and CRIF1. This will facilitate the […]

AVID200 is a TGF-? trap that specifically sequesters TGF-?I and TGF-?III to enhance antitumour immunity to inhibit tumor growth. AVID200 also avoids adverse side effect of depleted of TGF-?II. AVID200 is relatively short-lived in circulation, decreasing its capacity to exert desirable enhancement of anti-tumour immunity. To increase the effectiveness of TGF-? traps, a panel of […]

To investigate whether IO alters skeletal muscle adiponectin sensitivity and the mechanisms involved. 1. We will use L6 skeletal muscle cells treated with iron to determine if excess iron leads to adiponectin resistance. 2. We will examine temporal regulation of i) NLRP3 inflammasome and ii) oxidative stress by IO and using gain or loss of […]

This qualitative study will explore the social impacts provoked by the toddler & children-targeted health promotion program “Happy Smile” in small urban areas (state of São Paulo- Brazil). Mothers experiences within the program will be collected by the MITACS student , who will conduct interviews, informal conversations, and discussion groups to explore their understanding of […]

Inflammatory bowel disease (IBD) is a disease with unknown etiology that is characterized by uncontrolled intestinal inflammation and microbial dysbiosis. Qu Biologics’ Site Specific Immunomodulators (SSI) are a platform technology shown to improve the status of people living with IBD (Crohn’s disease and ulcerative colitis), with most of those patients showing clinical improvement also going […]

Le RPPSG vise à compenser environ 5% de ses captures par l’ensemencement de postlarves de homard produites en écloserie. Depuis le début de cette production en 2010, le RPSG a appris à bien maîtriser la zootechnie en écloserie. Il a identifié deux points majeurs à optimiser, soit les coûts importants liés la production de nourriture […]

Hypernasality is a speech disorders that results from excessive sound coming through the nose during speech. A speaker afflicted with hypernasality may be perceived as sounding flat and monotonous because the nasal murmur masks the inflections of the fundamental frequency (Kummer, 2008). However, the masking of prosody by the nasal murmur has not been investigated […]

This project aims to determine prevalence rates of Echinococcus species tapeworms in domestic dogs and to compare these rates to those obtained from wild canids including wolves, coyotes, and foxes. This will shed light on infection rates and risk factors for both the human population and their pet dogs. This research will benefit Bayer as […]

In this proposed project, a collaboration between Tel-Array Diagnostics and the UBC research team will result in the development of a fully automated and portable point-of-care test for breast cancer proteins from a single drop of blood. In order to achieve this ambitious goal, we will develop, optimize and validate a fully integrated microfluidic sample […]

This series of projects will provide coaches and sport scientists with a greater understanding of the relationship between training and performance. While there are several methods for monitoring how much and how hard athletes train, how these can be best used to predict future performance is still in question. The sports of rowing and middle-distance […]

Each knee contains two menisci, crescent-shaped pieces of cartilage that play a crucial role in absorbing shock and providing nutrition to the joint. The meniscus is one of the most commonly damaged areas of the knee, unfortunately the body cannot easily repair meniscal injuries, leaving patients with reduced mobility and severe pain. Surgical removal of […]

The project aims to translate developments in ultra-sensitive MRI sensors to a clinically-relevant setting. To create high-sensitivity sensors for better images, we aim to create a tight-fitting system which places the sensors—akin to antennas—closer to the brain. This will improve the quality of the signals that we can extract from the brain, and allow us […]