Face au changement climatique, les espèces doivent s’adapter à de nouvelles conditions environnementales. Le mécanisme majeur qui permet aux espèces de s’adapter à ce changement rapide est un mécanisme appelé “plasticité phénotypique”. La plasticité phénotypique est le mécanisme par lequel un code génétique produit des caractéristiques biologique différentes chez les organismes en fonction des conditions […]

The aim of the proposed research is to investigate the cellular mechanistic effects of supplementation with a hypocaloric meal replacement product (Optifast-900; Nestlé Canada) containing cysteine and glycine, which are amino acid precursors of the antioxidant glutathione. Impaired cellular glutathione redox normally occurs with aging and metabolic disorders, however, this study will focus on a […]

The aim of this research is to investigate the cellular mechanistic effects of supplementation with a hypocaloric meal replacement product (Optifast-900; Nestlé Canada) containing cysteine and glycine, which are amino acid precursors of the antioxidant glutathione. Impaired cellular glutathione redox is evident in obesity and metabolic disorders; Therefore, this study focuses on a population in […]

La fibrose pulmonaire idiopathique (FPI) est caractérisée par un remodelage des voies aériennes lié à des agressions répétées des cellules épithéliales alvéolaires (CEA). Ces CEA subissent une mort cellulaire programmée. Chez les patients atteints de FPI, des marqueurs du stress du réticulum endoplasmique (RE) et de l’hypoxie sont présents, tels les facteurs de transcription CHOP […]

Presently medical personnel do not have adequate tools to assess disorders of conscious awareness after severe brain injury if the patients have difficulty speaking & moving. These people are frequently deemed unresponsive when they may be “in there” but unable to respond. Our research team has developed a rapidly administerable, portable system that measures brain […]

The objective of this study is to uncover the relationship between cognitive deterioration and language performance in populations with dementia. The method used for this protocol does not require that words and grammar be taken into consideration but rather investigates coherence of discourse, which has the potential to be applied to studies of languages other […]

Le génie végétal est une alternative efficace et durable dans la stabilisation de berges, conférant aux sites une plus grande naturalité que les techniques classiques de génie civil. Il se base sur différentes approches, elles-mêmes faisant intervenir plusieurs espèces selon les conditions du milieu (pédologie, hydrodynamisme) et les contraintes en présence. Ce projet de recherche […]

Dans les sports impliquant l’utilisation du membre supérieur au-dessus de la tête, comme le tennis, les blessures à l’épaule sont fréquentes. Un des facteurs de risque de ces blessures est la faiblesse des muscles stabilisateurs de l’omoplate, en particulier le trapèze inférieur. Au cours des gestes sportifs, la faiblesse de ce muscle pourrait modifier les […]

Drug-induced dyskinesia is a debilitating side effect induced by anti-parkinsonian and antipsychotic drugs. Frequency can reach 80% in Parkinson’ disease and around 50% in schizophrenia patients treated with typical antipsychotics. Treatments for dyskinesia currently available have a very limited impact and generate important side effects. We have identified a new pharmacological target that may offer […]

The prevalence of diabetes is growing rapidly and currently, over 60 million people worldwide use insulin treatment to manage their diabetes. However, insulin treatment can result in hypoglycemia or low blood sugar levels. To date only retroactive treatments are available to treat hypoglycemia, which affects an individual’s quality of life and increases the likelihood of […]

In January 2016, the Centre for Ambulatory Care Education (CACE) at Women’s College Hospital completed the Homecare Curriculum. This online, simulation-based program is designed to help personal support workers, nurses, and rehabilitation professionals provide better care for older adults who wish to stay in their homes. The program presents learners with 3 virtual home environments […]

In this project we aim to generate simple assays similar to commercial pregnancy tests that can detect the presence of specific molecules (metabolites) related to disease conditions. We will use our knowledge and experience to generate easy-to-use strips that will allow specific detection of health-relevant metabolites that can be used in clinical or at-home settings […]