Preparation of Phosphonium Cumulene Cations

In the last two decades there has been growing interest in understanding the structure and reactivity of chemicals containing phosphorus. Phosphorus compounds are known for their applications in organic synthesis, materials science, and catalysis. Developments in these applied areas has been enabled through fundamental studies which describe synthetic methods for preparing new phosphorus molecules. Fundamental […]

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3D in silico modelling of prostate cancer growth and treatment

Prostate cancer is a prominent cause of death in Canada. A better understanding of how prostate tumours grow and respond to treatment is vital; however, typical lab methods used to study cancer have key limitations. To compensate for these shortcomings, computational models have revolutionized the study of cancer. This research proposes modifying an existing 3D […]

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The CO2 redox flow battery development: Bifunctional heterostructured and sub-stoichiometric Magnéli-phase electrocatalysts for negative and positive electrodes

The world’s stringent need to transition to a low-carbon industrial economy is more pressing than ever and requires an ambitious departure from traditional processes through innovation, development and implementation of different breakthrough technologies within a strict timeline. Agora is tackling two energy challenges simultaneously with its proprietary CO2 Redox Flow Battery (CRB) technology by enabling […]

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Optimisation du processus d’ajout d’un médicament à la pharmacie

Le Département de pharmacie du CHUM est responsable de la gestion du service des médicaments dans tout l’hôpital afin de répondre aux besoins des patients (médicaments servis au nom du patient et médicaments disponibles à l’unité de soins sur validation et au commun dans différentes localisation dont les cabinets automatisés décentralisés). En particulier, la pharmacie […]

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Shape dependence of THz metasurface and its applications

THz waves are receiving great attention in, for example, medical imaging as well as 6G communication. Basic research using THz waves for such applications is being actively conducted. However, since the commercially available THz components are still bulky and difficult to use, the need for a compact THz system has been growing. In this context, […]

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Structure-Activity Relationships of Hafnium Dioxide Nanoparticles for Cancer Radiotherapy and Imaging

Nanoparticles made from hafnium dioxide (hafnia; HfO2) have emerged as a potential enhancer of cancer radiation therapy. Such nanoparticles allow for reduced doses of radiation to be used on tumors, sparing healthy tissue from side effects without reducing its anti-cancer effects. However, despite their potential, it is not yet known how different nanoparticle properties, such […]

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Mechanistic Analysis of Cross-Coupling Reactions

Palladium-catalyzed cross coupling is one of the most powerful tools in modern synthetic chemistry, with is collaborative discovery recognised with the 2010 Nobel Prize for Chemistry. This class of reactions has had a huge impact on the way in which chemists think about building fine chemicals, because it allows for clipping of two molecules together […]

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Effectiveness of Targeted Individualized Multi-modal Treatments in Adults Suffering from Persistent Concussion Symptoms as Compared to a Self-Directed At-Home Program

Disabilities secondary to traumatic brain injury are a major source of burden. Specifically, patients in Ontario seeking tertiary care for persisting symptoms following mild traumatic brain injury (mTBI) result in health costs of over $110 million annually (Hunt et al). Numerous treatments have been utilized and studied in an attempt to treat persistent postconcussive symptoms. […]

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Deep Learning Methods for Design of RNA-targeting Small-Molecule Antibiotics

Growing antibiotic resistance is a major threat to global public health. One way to combat this problem is through the development of antibiotics that act against bacteria in new ways. Historically, antibiotics work by interacting with proteins in the bacteria, which are needed for the cells to reproduce. However, recently, it has been shown that […]

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Design of Tunable Surface Coatings for Magnetic Nanoparticles for the Adsorption and Removal of Organic Contaminants

This project entails the design, synthesis, and characterization of porous surface coatings made from metal–organic frameworks for magnetic nanoparticles. The combination of these two materials will allow for the removal of organic contaminants that currently interfere with the correct functioning of DNA and RNA extraction test kits (e.g., COVID-19 test kits). As developers and producers […]

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Extended-life cold-trap: Zero Point Cryogenics

Zero Point Cryogenics is Canada’s manufacturers of dilution refrigerators, the cryogenic platform for enabling quantum technologies. To advance our product offerings, we need to innovate beyond what is currently offered on the market. Through this Mitacs internship, Zero Point Cryogenics will work with the University of Alberta to develop a new feature for our dilution […]

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