Optimal control problems and reaction-diffusion systems have many applications in pharmaceutical research.  For instance, the enzymatics collagen matrix degradation and the principal process governing drug transport inside a solid tumor could both be described by reaction-diffusion systems.  Solving these systems using effective numerical algorithms will benefit drug product design, drug delivery and cancer treatment.  Since […]

Recently it was shown that cells taken from adult skin could be converted to cells possessing “stem-cell-like” characteristics by a process called cellular reprogramming.  However, the use of these cells is limited by our understanding of how to derive mature and functional cells, such as blood cells that could be used for disease treatment.  We […]

Immune thrombocytopenia (ITP) is a common blood disorder characterized by low platelet counts and an increased risk of bleeding. Many patients with ITP can be maintained with conventional therapies, but when an invasive procedure or surgery is planned, a short course of treatment is needed to rapidly increase platelet counts preoperatively so that dangerous bleeds […]

A simple and facile route for the construction of highly sensitive electrochemical enzyme biosensors has been proposed using carbon nanotube (CNT) complexes with a conducting poly(thiophene) polymer. Glucose oxidase was used as a model enzyme for the construction of the advanced biosensors. Glucose biosensors, exhibiting sensitivity higher than any biosensor based on CNTs and other […]

Since the advent of rail transportation, the integrity of the rail and track conditions play a significant role in ensuring that trains are able to move people safely. Although this work has been hazardous since rail transportation was created, there have been few successful attempts at improving location awareness of approaching trains and the location […]

Determining the properties of materials has always been one of the primary goals of research in materials science. Computational models for materials’ property determination are hindered by their high computational cost; it can take weeks (even years) to develop and evaluate a computational model for a single property of a single material. The current approach […]

During the past two decades, the primal-dual scheme has been a major tool for the design of algorithms with very good approximation factors for NP-hard problems. This method is based on the duality theorems of Linear Programming (LP): Strong duality ensures that satisfaction of complementary slackness conditions implies optimality of a (fractional) solution. “Good” relaxation […]

  By the end of the internship, the students should be able to provide Lancaster Sheet metal (sponsor company) with a valid design for a collapsible intermodal container in order to minimize their shipping costs. As understood from Lancaster Sheet Metal, the company ships its products in intermodal containers, and then the containers are sent […]

  The ability to make safety-related decisions and to demonstrate compliance with regulatory or safety limits is of great importance in the nuclear industry. For example, we may be interested to assess whether a component (such as the pressure tube which carries fuel) has undergone physical changes that have exceeded its allowable limits (e.g., the […]

  Vitaphone 3100 BT is a portable outpatient heart monitor that can be used to detect disturbances to the normal rhythmic beating of the heart (arrhythmia). Arrhythmia is associated with heart disease, heart failure and stroke. A clinical effectiveness and usability study will be conducted as well as an economic evaluation on the Vitaphone 3100 BT, and will be […]

Depression is expected to become the second leading cause of disease burden worldwide by the year 2020. Cognitive Behavioural Therapy (CBT) is one of the most effective methods of treatment for depression. CBT may be less effective, or ineffective, in the setting of patients in receipt of disability benefits who are likely to, on average, […]

Create an automated “on line” decision tree for crop conditioning that allows predict and control the behavior of key indicators during the grain storage by Identifying the main factors that are related to the drying and storage of grain as well as the relations between those factors.