Investigating the role of bacteria in abdominal pain and chronic constipation.

The bacteria living in our gastrointestinal system, the gut microbiome, play a key role in human health and disease. Multiple studies demonstrated altered gut microbiome in patients with constipation or abdominal pain but knowledge of a clear cause-effect relationship or underlying mechanism are lacking. We found previously that microbiota from patients with irritable bowel syndrome […]

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Laser Powder-Bed Fusion of Heat Exchangers

The laser powder-bed fusion (L-PBF) process is a novel additive manufacturing (AM) technique used to produce metal objects layer-by-layer using a laser source. Aim of this project is to design an optimized heat exchanger with enhanced heat transfer performance with the advantages offered by additive manufacturing (AM) technology such as complex design and lightweight. The […]

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Bezel-Free LCD Display system design and prototyping

Large area digital displays are often made using tiled liquid crystal display (LCD) units to form a video wall. However the seams or bezel gaps that result are often not acceptable. This project aims to demonstrate and prototype a solution to seamlessly tiling liquid crystal displays (LCDs) to form a large formal digital display. Tilted […]

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Determination of the mechanism and kinetics of melting of carbon-free direct reduced iron (DRI) made using hydrogen reduction to eliminate CO2 from steel production, and its impact on EAF steelmaking process.

The iron and steel industry are the major contributors to global industrial CO2 emissions. Coke making plants and blast furnaces are the largest emitters in this sector. To meet the requirements of CO2 emission mitigation by 2050 to net zero, hydrogen-based ironmaking is an alternative for the fossil fuel ironmaking route. The overall objective of […]

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Economic model of Ulipristal Acetate in the long term, intermittent treatment of uterine fibroids — a Canadian setting

Health economic evaluation compares the associated costs and the clinical outcomes of multiple treatment alternatives and is presently used by payers as one of the many types of evidence to inform which drugs to fund. Given existing health-care budgetary constraints, payers are increasingly interested in knowing whether a new health technology will provide value (i.e. […]

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Improvement of the adhesion and release mechanism of antiviral coatings via using hydrogels and adhesion promoters

The pandemic has shown us the importance of controlling different routes of transmission of infectious diseases. In order to slow down or stop infectious diseases, cleaning and disinfection of ‘high-touch’ surfaces need to be performed regularly. However, the development of an effective antiviral surface coating provides an additional protection layer against disease transmission. In this […]

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Development of Load Case Model for the Design of Butt & Top Grapples

The sponsor company, Tigercat specializes in the design and manufacturing of premium quality forestry equipment and specialized off-road industrial equipment. This four months internship project will provide the company a set of load cases validated on a new design, optimized detail 3D and 2D models, selected material lists, and FEA simulation results of a tracked […]

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Additive Manufacturing of Functionally Graded Materials and Shape Memory Alloys with Biomedical Applications

Functionally graded materials (FGM) offer a better alternative than the conventional coating techniques since it eliminates the sudden change in composition between different materials. This project proposes to print FGM biomedical implants using a combination of titanium (Ti) powder and hydroxyapatite (HA) powder. Titanium will offer the required mechanical strength for load-bearing implants, while HA […]

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Evaluation of Machine Learning Methods for Portfolio Replication of VIX Futures

During the past two decades, the CBOE Volatility Index (VIX® Index), a key measure of investor sentiment and 30-day future volatility expectations, has generated much investor attention because of its unique and powerful features. The introduction of VIX futures in 2004, VIX options in 2006, and other volatility-related trading instruments provided traders and investors access […]

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Evaluating an Expanding Prodrug Platform for Controlled Drug Delivery

The development of new strategies to improve drug delivery has the potential to significantly improve patient outcomes. Ripple Therapeutics has developed a new approach to developing implants based on a discovery that prodrugs (an inactive version of a drug) can be processed into an implant without the use of a polymer to hold the implant […]

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