Intracellular growth of Mycobacterium tuberculosis: prospects for drug discovery

The success of Mycobacterium tuberculosis (Mtb), the infectious agent of tuberculosis (TB), lies in its ability to primarily infect, reside, and multiply in the lungs of patients. Mtb infects white blood cells termed alveolar macrophages and hides from the host immune response as well as from many antibiotics used for treatment, creating additional challenges for […]

Read More
Enhancing Software Lifecycle Visibility and Traceability

Teams of specialized workers develop most software. For example, one team may specialize in the requirements that describe what the software is to do. Another team may specialize in producing the software itself. Yet another team may specialize in determining whether the software meets the desired requirements. Supporting communication between all these teams is challenging: […]

Read More
Roche Lake Eutrophication study

Roche Lake is the Roche Lake is the largest lake among 12 highly productive water bodies in the Thomson-Nicola region of BC’s southern Interior Plateau. It has experienced algal blooms over the past four years indicating a change in nutrient loadings to the lake. Roche Lake suffered a winterkill of more than 50% of fish […]

Read More
Integration of INTERCONNECT and Cadence with an emphasis on co-simulation of CMOS drivers and optical ring modulators

The idea of using light for transferring data has been developed rapidly since 1960s. Today, using light for short-distance communication, as an alternative for copper wires, is rapidly growing mostly because of its broadband communication characteristics. Optical communication systems consist of both electronic and photonic components. Designing such systems will benefit from an Integrated Development […]

Read More
Discovering the mechanism of action of a novel immunotherapy, Cat-SPIRE, using a network analysis

Allergic rhinitis is an inflammatory condition of the nasal passages induced after allergen exposure in sensitized individuals. Approximately 20-25% of Canadians suffer from allergic rhinitis, with cat allergy affecting up to 15% of people with allergic rhinitis and/or asthma. Although existing immunotherapies have some effectiveness, these have safety problems and require long-term treatment. A novel […]

Read More
Genomics profiling of peritoneal mesothelioma and patient-derived xenograft models for in vivo biomarker validation

Peritoneal Mesothelioma (PM) is a rare type of cancer affecting the protective membrane surrounding the abdominal cavity and the second most common type of mesothelioma, consisting about 10-20% of the diagnosed cases. The underlying cellular and molecular mechanisms of peritoneal mesothelioma pathology are greatly understudied. In this proposal, we aim to enhance the current knowledge […]

Read More
Minimizing potential induced degradation in crystalline-silicon based photovoltaic solar modules – Year 3

The demand for photovoltaic solar modules has increased tremendously in recent years. Unfortunately, photovoltaic solar modules are prone to potential induced degradation, i.e., a decrease in the power delivered from such modules arising as a consequence of them operating continuously under high applied voltages. This project aims to design a protocol for the accelerated testing […]

Read More
Unseen Enemy: Global Pandemic Knowledge Mobilization

Our deadliest enemies are the ones we cannot see – viruses or bacteria that lurk and mutate, and grow in resistance, until they become an unstoppable pandemic. This year four interns will work alongside the Tech Samurais company to produce key communication tools that will make effective interventions into the Canadian and global conversation about […]

Read More
Development of a simulation-based tool to predict the aerodynamic loads on heavy duty trucks

Agility Fuel Systems manufactures fuel systems for converting heavy-duty trucks from diesel fuel to compressed natural gas. The system components are typically situated between the cab and the trailer or along the sides of the truck. Because natural-gas components are typically larger than their conventional counterparts, the converted trucks may experience a larger aerodynamic drag, […]

Read More
Application of Machine Learning Methods in Vancouver Island Supply Capability Determination

This project is a feasibility study of applying Machine Learning to Vancouver Island Load Supply Capability determination. The intern is expected to apply neural networks and other machine learning methods to train a transmission operation decision making model to determine the load supply capability of Vancouver Island. An operation scenario database covering equipment status and […]

Read More
Integrating high resolution remote sensing of multi-scale hydrogeomorphology into long-term river management

Large northward-flowing boreal rivers are an important hydroelectric resource, but effects of river regulation on downstream geomorphology and aquatic ecosystems are difficult to predict. Peace River, BC presents an ideal case study of river response to regulation, with continuous monitoring since dam construction in 1967. However, current understanding of system changes is based mainly on […]

Read More