Next generation cannabinoids for pain, inflammatory response, and cancer – Utilizing allosteric pathways in GPCRs to achieve greater specificity and bias

The recent legalization of cannabis in Canada offers a unique opportunity to conduct fundamental research without the bureaucracy issues faced in other countries. The current state of cannabinoid (CB) based therapies have focused their use in the treatment of cancer, pain, inflammation and opioid addiction, and suffer from unwanted side effects and lack of efficacy. […]

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Development of the Metaplex Immuno-Oncology Platform – Formulation Component

Current cancer immunotherapies, although highly successful, are complex to implement, costly, and only effective in small patient populations with specific cancer types. We propose to overcome these problems by developing small molecules to induce immunogenic cell death (ICD), a cancer cell death process that engages the immune system to recognize and eliminate cancer cells and […]

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Changes in the impact attenuation performance of field-used hockey helmets over time

A hockey helmet should be capable of protecting the user over the helmet’s intended life span. There is currently little evidence quantifying the changes in the impact attenuation performance of field-used hockey helmets over time. This study will collect a large sample of field-used hockey helmets from the hockey community for impact testing. The sample […]

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A Step Towards a Lower Carbon Future: Integrating Closed Loop Geothermal Technology in District Cooling Applications

This research aims to provide an affordable, clean energy alternative to meet the world’s cooling demands. As global warming, urbanization, and society’s dependency on digital storage increases, the world’s cooling demands continue to rapidly grow with predictions showing that they will outweigh heating demands by 2060. The majority of these demands are currently being met […]

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Deciphering the catalyst-ionomer interface in fuel cells: Molecular dynamics simulations of local transport properties

Polymer electrolyte fuel cells are a key technology in the race against climate challenge, and while commercial applications are increasingly common, challenges remain in cost, performance, and durability. Most of the issues that prevent full commercialization affect the catalyst layer, the region where the power-generating electrochemical reactions take place, like the oxygen reduction reaction. This […]

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Development and evaluation of the OptiSolve Pathfinder optical assay for viral particle detection on surfaces in environmental monitoring

OptiSolve Pathfinder is a diagnostic tool that allows the easy identification of contamination on surfaces through imaging. Although viral and bacterial organisms are always a threat, during the current COVID-19 pandemic, the ability to easily identify and quantify viruses is of primary importance. The Pathfinder solution developed by OptiSolve will significantly improve quality of care, […]

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Development of an assay for personalized synergistic blockade immunotherapy treatment of COVD-19 patients using CytoFind™

The current COVID-19 pandemic has posed many challenges to healthcare professionals as they deal with managing the primary disease and it many complications. The proposal aims to develop, test, and validate an assay to detect quickly immune checkpoint targets in T cells in peripheral blood with high specificity and sensitivity using a diagnostic device, CytoFind, […]

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Frontline organizations and emergency planning in the COVID-19 pandemic

Emergencies in inner-city neighbourhoods come in many forms—illness, fire, violence, homelessness. The COVID-19 pandemic is a different kind of emergency. It is a global crisis, and requires unprecedented changes to everyday life to protect all members of society. COVID-19 has highlighted many long-standing gaps in access to basic needs and has expanded understandings of basic […]

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The COVID-19 infodemic : Telling Facts from Fakes

The Internet has become a major source of information, with a single piece shared across different platforms potentially reaching millions in a short period of time. As Covid-19 spreads across the world, the misinformation and fake news around it also spread. For each fact about Covid-19 made public, a large body of misinformation grows and […]

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Continuation of Characterization and Design of Additively Manufactured Components for Materials Integrity

Rapid prototyping, or 3D printing, has inspired the imagination of the general public, from simple build-it-yourself “hobby” machines using polymer-based binder material with inkjet functionality, to portable printers that can fashion components in zero gravity on the International Space Station. The functionality is user-friendly, in that printed material is dropped onto a substrate in viscous […]

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