Development of nanoparticle in vivo labeling contrast probes for tissue clearing 3D microscopy compatible with multi-modal imaging in fluorescence, dark field, MRI, CT and electron microscopy modalities.

High resolution 3D microscopy in combination with tissue clearing techniques such as CLARITY, iDISCO, CUBIC is a rapidly growing area of biomedical research. It also has high potential to replace traditional 2D histology to become a method of choice for the analysis of tissue biopsy samples used in diagnosis of cancer and other diseases. However, […]

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Exploring neuroimaging methods to assess the effects of music therapy

The objective of this project is to research new technologies and methods to help in the assessment and functional imaging of neuroplasticity related to music therapy. The approach utilizes key novel technologies being researched in partnership with Dr. Ryan D’Arcy. It takes advantage of on-going, integrated work with Music Heals to research music therapy as […]

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Program evaluation for JUMP Math: An empirical assessment of a resource for math education

Canadian math scores are in decline. Numerous studies have demonstrated the importance of numerical proficiency for outcomes such as health, employability and financial stability. Therefore, the effectiveness of a child’s math education is key to future success. It is of utmost importance, then, to identify effective math education programs. The proposed project will evaluate JUMP […]

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Development of a personalized in-vitro model for dystrophic muscle endogenous repair for drug discovery

Duchenne muscular dystrophy (DMD) is a genetic disorder resulting in progressive muscle degeneration. Satellos Bioscience Inc is developing small molecule drugs that target and modulate DMD muscle stem cells to repair the dystrophic muscle. Despite the advantages of DMD animal models, they are not always predictive of human DMD phenotypes, or their response to drug […]

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Municipal Energy Futures Project: A Case Study of Regina, Saskatchewan

Meeting Canada’s commitment to the Paris Agreement will require a fundamental shift in the energy systems of Canadian cities. Regina, Saskatchewan is located in the sun-belt of Canada and also lies within the Great Plains wind corridor. Recognizing this potential for renewable energy, the City of Regina has committed to a target of meeting 100% […]

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Formulating a novel goat-whey based drink and studying its nutritional and health functions – Year two

This project will create novel goat milk-based products and test their health effects in healthy adults. Interest in goat milk is increasing, mainly due to two market trends: consumers’ new taste trends for niche/ethnic products, and the perception of goat milk having added health properties. Goat milk is perceived as having intestinal anti-inflammatory effects and […]

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Breeding and migratory habitat use in Eastern Whip-poor-will in relation to forest management

Understanding how managed and harvested forests can still provide high-quality habitat for forest birds is key to ensuring both productive forestry operations and sustainable bird populations. We propose to use GPS-tracking technology to study how the Eastern Whip-poor-will (Antrostomus vociferus) uses habitat on its Canadian breeding grounds, during migration, and on the wintering grounds. The […]

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Root associated microbiome of trees growing in a fractured bedrock toluene phytoremediation site

Phytoremediation is a promising in-situ technology that uses plants and its associated microorganisms (particularly bacteria and fungi) to clean up contaminated soils. The efficacy of these processes however, requires an in-depth knowledge on the diversity of microbial communities closely interacting with plant roots. Several studies have demonstrated that plants growing in contaminated soils select for […]

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Realizing Large-Scale Production of High-Quality Human Induced Pluripotent Stem Cells through a Systematic Investigation on the Characterization and Protocol Optimization of Single-Use, Scalable, Vertical-Wheel Bioreactors

For stem cell discoveries to translate into improved health solutions for Canadians, we must use engineering manufacturing practices to grow enough cells safely and efficiently. Pluripotent stem cells (PSCs) have the unique ability to transform into any cell in the body when subjected to specified environmental conditions. They are invaluable in studying disease and gene […]

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Antigen Tracking of the DPX-R9F immunotherapy using MRI – Part 2

IMV Inc. is developing injectable cancer immune therapy using the company’s DPXTM technology. DPX is a patented formulation that displays excellent tumor control and provides a long lasting and specific effect. The way by which this therapy exerts its effect is unclear but the translational team at IMV is determined to discover its mechanism of […]

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New Approaches to Mine Closure in Nunavik, Québec

Mine closure is the final stage of a mine’s lifecycle and can have complex social, economic, and cultural impacts on nearby communities. These impacts include population decline, reduced services, household stress, ecological change, and reduced access to land-based activities. These impacts become more likely when communities are not engaged with during the closure planning process. […]

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