Analyse et quantification de l’information de texture dans les lésions cutanées pigmentées

Certaines caractéristiques des lésions cutanées pigmentées ou naevus signalent la présence du cancer. La texture (variation spatiale de la couleur/de l’intensité) fait partie de ces caractéristiques répertoriées. Ce travail de recherche vise à quantifier cette information de texture afin d’améliorer le rendement des méthodes de diagnostic automatique du mélanome. À l’heure actuelle, les dermatologues sont […]

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Variations structurelles des génomes humains en utilisant les séquences courtes des technologies de séquençage à capacité élevée

Ce stage servira à élaborer des outils et à résoudre des problèmes algorithmiques liés aux séquences courtes obtenues grâce aux technologies de séquençage à capacité élevée (les nouvelles technologies de séquençage du génome humain). La résolution du problème aidera les chercheurs en biologie et biologie moléculaire à utiliser ces nouveaux outils afin de trouver des […]

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Algorithmes approximatifs pour le reséquençage du génome humain en utilisant les séquences courtes obtenues grâce aux technologies de séquençage à capacité élevée

Traditionnellement, la variation de la génétique humaine a toujours été étudiée au niveau du polymorphisme d'un nucléotide simple (PNS). Or, il est évident que la variation de la génétique humaine va bien au­delà du PNS. De nouveaux projets visant à identifier sa variation structurelle ont été lancés en utilisant les technologies de séquençage à capacité […]

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The Identification of Gene-Environment Interactions in Non-Hodgkins Lymphoma

Non-Hodgkins Lymphoma (NHL)is the 5th most common cancer in Canada and its incidence has been increasing steadily every year. Unfortunately, little is known about the causes of the increased incidence, although it is likely that some combinations of genetic and environmental factors are involved. This internship with the BC Cancer Agency will examine genes that […]

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Analysis and Quantification of the Textural Information in Pigmented Skin Lesions

There are certain features of skin lesions or moles that are indicative of cancer. Texture (spatial variation of colour/intensity) or patterns is known to be one of these features. This research seeks to quantify this textural information in order to improve the performance of methods to automatically diagnose melanoma. Currently, dermatologists are very proficient at […]

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Approximate Algorithms for Resequencing of Human Genome using High Throughput Short

Human genetic variation has been traditionally studied at the single nucleotide polymorphism (SNP) level. It is clear that, human genetic variation extends beyond single nucleotide polymorphism. New projects aimed at identifying structural variation have been initiated through the use of high throughput sequencing technologies. Although the new sequencing technologies produce short reads with respect to […]

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Structural Variations in Human Genomes Using High Throughput Short read technology

This internship will be developing tools and solving algorithmic problems related to short read technologies (the new technologies of sequencing the human genome). The problem being solved will help the biology and molecular biology researchers to use these new tools to find variations between different individuals. This will be very important step in realizing the […]

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GPU based High Throughput Sequence Mapping for Re-Sequencing Short Reads

The throughput of next-gen sequencers is about 20 to 90 million base pairs per hour and increasing. To map this huge volume of data to reference genome and reduce the computation time, current mapping tools are installed on the clusters. Although using a cluster reduces the computation time but the cost of having such a […]

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GPU-oriented Structural Variation Detection in Human Genomes

Fast structural variation (deletion, insertion and inversion) detection between genome of different individuals is the main goal of this project. The internship team is planning in extending new algorithms to reduce the number of false positive calls (especially for deletions) and to parallelize it using Graphics Processing Unit (GPU). The standard approach implementation of the […]

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Low-cost complex genome assembly and annotation

There is a pressing need to apply genomics-based tools for rapidly evaluating the impact of industrial and municipal waste management practices and climate change. In order to do this, information about the genome from relevant North American species is needed, yet acquiring these complex genome sequences had been cost and resource prohibitive until recently. Working […]

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