Vaccine industry is evolving towards more efficient manufacturing systems. Adenovirus vectored vaccines are among new promising approaches for more efficient vaccines design and production. Recombinant Ad (rAd) can be used as gene deliver vector carrying different antigens for delivery into Ag-presenting cells (APC) eliciting a targeted immune response. Alternatively, antigens can be exposed on the […]

This project intends to research vaccine manufacturing process from a broader perspective and apply Quality by Design (QbD) concepts to develop a robust novel process for commercial vaccine production. To implement QbD principles, the impact of several process parameters (including cell density, pH, temperature, and harvest time) on the Critical Quality Attributes (CQAs) of the […]