Applications of deep learning to large-scale data analysis in mass spectrometry-based proteomics – Year Two

As a result of recent advances in high-throughput technologies, rapidly increasing amounts of mass spectrometry (MS) data pose new opportunities as well as challenges to existing analysis methods. Novel computational approaches are needed to take advantage of latest breakthroughs in high-performance computing for the large-scale analysis of big data from MS-based proteomics. In this project, […]

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A novel home cage testing environment for frontal cortical neuronal recording in marmosets – Year two

Marmosets are a valuable model for investigating the neural bases of behaviour and cognition, and there has been a substantial increase in marmoset use in translational neuroscience research over the last few years. A comfortable environment is critical for marmoset neurophysiological testing. At Rogue Research the fellow will be involved in developing a unique apparatus […]

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Development of easy-to-prepare pulse-based meals for consumption by office workers to combat the negative health consequences of a sedentary work environment

The project will involve the development of seven “pulse-based” lunches, which are designed to be easy to prepare (i.e. “out of the package”) for people in a typical busy office work environment. Pulses include non-oil legumes such as lentils, chickpeas, beans, and peas, which are a major component of the Canadian agricultural industry and an […]

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The making of a woman feature filmmaker: Gender and cultural production in a Montreal-based film school

In Canada, women have made significant inroads in television, web series, documentaries, and experimental films. But few women directors and screenwriters participate in big-budget feature film production. This study explores the marginalization of women in the feature film industry through the lens of film production training. As previous studies have shown, film education can shape […]

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Cancer tissue classification using machine learning/deep learning algorithms

Raman spectroscopy is a non-destructive laser-based optical technique that provides information on the molecular composition of biological tissue. Using this technique, it is possible to distinguish different types of tissue and use this information to develop prognostic tests to evaluate, for example, how a patient will respond to a specific therapy. Combined with other spectroscopy […]

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Inhibiting somatostatin signaling in animal models of diabetes

The prevalence of diabetes is growing rapidly and currently, over 60 million people worldwide use insulin treatment to manage their diabetes. However, insulin treatment can result in hypoglycemia or low blood sugar levels. To date only retroactive treatments are available to treat hypoglycemia, which affects an individual’s quality of life and increases the likelihood of […]

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Canadian Communities of Practice in Global Health: meeting the SDG challenge – Year two

Canada’s commitment to the Sustainable Development Goals (SDGs) has implications for both domestic and foreign policy in a complex, shifting, and interdependent global health system crowded with multiple actors and stakeholders. The array of activities involved with global public health practice necessitates engagement with health policy and systems research (HPSR), and Knowledge Translation (KT) is […]

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Development of miniature fluorescence microscope with optogenetically synchronized patterned illumination – Year two

We propose development of miniature fluorescent microscope with flexible spatiotemporal photostimulation patterns of ensembles of neurons in freely behaving animals.For precision and targeted photostimulation of light-activated proteins (opsins), the light beam from high power incoherent light source will be shaped by user-controlled digital micromirror device (DMD). The light patterns formed by DMD will be sent […]

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Investigating the cell biology of cannabinoid synthesis in Cannabis sativa

Cannabis sativa is a plant well-known for its production of cannabinoids, which are lipids with unique pharmacological properties. These compounds are produced mainly in female floral buds in specialized epidermal outgrowths known as glandular trichomes. These structures consist of a long stalk supporting a disk of biosynthetically active cells that produce the cannabinoids. Cannabinoid biosynthesis […]

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