Ce projet vise à élucider davantage le mode d’action de certains produits élaborés par ProMetic BioSciences inc. sur certaines cellules myéloïdes humaines en relation avec une réponse cellulaire impliquée dans un nombre grandissant de maladies humaines. Il s’agit d’un stress du réticulum endoplasmique (RE), un organite cellulaire impliqué dans la synthèse des protéines. Cette dernière […]

Most of the heavy oil and bitumen produced in Western Canada is transported through pipelines to refineries in North America. Prior to transportation, the high viscosity of those fluids must be reduced by either dilution with a light solvent or upgrading. The high costs associated with handling diluents has increased the interest in upgrading; that […]

Polymer ferroelectrets are light weight and flexible materials that display piezoelectric behaviour. These properties make them ideal for use as transducers in the aerospace industry. However, the traditional methods used to prepare high performance polymer ferroelectrets cannot be used for large scale manufacturing due to poor reproducibility or high cost. Furthermore, these manufacturing techniques rely […]

The forest industry in British Columbia (BC) is facing increasingly difficult challenges regarding fibre supply. New winch-assist technology that enables fully mechanized ground-based forest harvesting on steep terrain has been increasingly used in BC since 2016. The new systems have improved safety and provide access to fibre that was previously uneconomic. New low-consumption small-size cable […]

Persistent pain is pain that is prolonged beyond normal healing time, usually defined as three months. Approximately one in five Canadians suffer from persistent pain conditions such as low back pain, osteoarthritis and fibromyalgia. These conditions account for $43-60 billion in healthcare costs. Prescribed exercise has been shown to decrease pain while increasing function and […]

Global population growth, urbanization and changing climate patterns have increased the demand for potable water, wastewater reuse and value recovery from wastewater, and for remediation of industrial process water. Population growth also results in increased demand for the shipping of goods by ocean freight, with the associated risk of the transport of unwanted marine life […]

Chemicals manufactured and used in society degrade through physical and biological processes (e.g., photolysis, biotransformation) into break-down products (e.g., metabolites). Most “parent” chemicals can breakdown relatively quickly so that they are not persistent or bioaccumulative; however, some metabolites formed during the degradation processes can persist in the environment thus requiring consideration for ecological and human […]

The over-arching goal of our project is to develop a robust next-generation gene-editing platform to repair the deleterious mutations that are responsible for genetic diseases such as Cystic Fibrosis and cancer. First-generation precision endonuclease technologies have been tremendous for in vitro gene disruption studies and ex vivo treatments, but there has been limited success at […]

Dunes are common bed features in large sand-bedded rivers and are significant sources of in-channel roughness. Reliably estimating roughness is crucial for the prediction of flood flows, but roughness is crudely represented in hydraulic models widely used by environmental consultants and engineers. Roughness is treated as a calibration knob in these models, adjusted to force […]

The project goal is to determine the clinical utility of Orpyx LogR technology to detect gait changes and their efficacy to predict and monitor fall risk. Project I will use existing data to determine sensitivity and specificity for prospective classification of fallers and non-fallers for a composite measure drawn from an extensive battery including single […]

The motivation for this research comes from an overall need to improve the performance of high voltage module (HVM) and to reduce the size and its material costs while maintaining its efficient performance, with no partial discharge, arc or thermal issues. In particular, stable transient and steady state performances must be achieved for medical X-generators […]

Canonical methods of molecular discovery and reaction optimization rely on “trial-and-error” approaches and slow experimentation with low discovery rates. By harnessing high-throughput experimentation (HTE) with machine learning (ML) methods, artificial intelligence (AI) and robotics, we have the potential to dramatically accelerate the discovery and preparation of next generation molecules and materials. We will extract, unify, […]