Advanced investigation of amphoteric reagent-based cyclization of peptides

Encycle Therapeutics is a Toronto-based company that develops new therapeutics for the treatment of autoimmune diseases. Our competitive edge derives from a platform technology that allows for the more efficient synthesis of macrocycle- (ringlike peptides) based therapeutics. This platform involves a proprietary reagent called aziridine aldehyde. This new technique has demonstrated significant potential for the […]

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Risk-Aware Decision Support Systems for Critical Infrastructure Protection and Territorial Security

Robotic sensor networks (RSN) are increasingly applied to Critical Infrastructure Protection (CIP). In such an application, a RSN is deployed to safe-guard some critical infrastructure (e.g., building, pipeline, etc.) in a secure and reliable fashion. By actively considering risk as a major driving force,  this project aims at deciding on the optimal configuration of an […]

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Blood and nasal biomarkers of Cat-SPIRE Efficacy

The Cat-SPIRE vaccine reduces symptoms in those who suffer from cat allergy. Two interns will work on complementary projects that will evaluate blood and nasal biomarkers of Cat-SPIRE efficacy. One trainee will examine changes to the DNA in special immune cells called dendritic cells, isolated from blood. The other trainee will examine markers of inflammation […]

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A Novel Design of High Temperature Ultrasonic Transducers, Manufacturing, and Testing

The project objective is to design and manufacture ultrasonic sensors capable of operating at temperatures up to 800 oC. Such transducers can be affixed to hot piping systems and pressure vessels in petrochemical plants, electrical power generating stations, and manufacturing plants. These sensors can then provide continuous information to the plant operator regarding the onset […]

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Anti-islanding detection for renewable energy systems in distribution system

Integration of renewable energy systems into grid is an effective solution to the electric energy shortage and environmental pollution. A number of technical challenges may arise with increased grid-connected renewable energy systems. One of the most important issues is how to achieve the islanding protection. Many anti-islanding detection methods have been reported for single renewable […]

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Using CityEngine for Parameterized 3D Modeling of Regional Growth Scenarios

In 2006, the Government of Ontario introduced “Places to Grow: Growth Plan for the Greater Golden Horseshoe” to control urban sprawl, protect farmland and green spaces, create complete communities and revitalize downtowns and urban centres. Key specifications include minimum intensification targets, such as requiring 40% of new residential development to occur in existing built-up areas. […]

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Development of Colour-Changing Indicator Label for Healthcare Applications

Lunanos Inc. and Ryerson University's School of Graphic Communications Management are seeking to collaborate on a six-month project to develop an innovative colour-changing indicator label that will be used in healthcare facilities to track the cleaning of various equipment and surfaces to reduce the frequency of healthcare-associated infections (HAI). In Canada, 1 in 10 patients […]

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Model for implementing and continuously improving the automated change management process for construction mega projects

Current communication means such as; Spreadsheet, the internet and Emails are not good enough when a change happens in a Billion $ oil and gas project where hundreds of technicians, engineers, managers, contractors from various disciplines in different locations are involved. The solution is an automated workflow process. Simply put, workflow is the step-by-step procedure […]

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Intramucosal Lorazepam spray: Whole Cell and Extracellular Eelctrophysiological Study of Pharmacokinetics and Pharmacodynamics

Epileptic patients have a long term risk of recurrent seizures and the mainstay of treatment for controlling seizures is antiepileptic drugs. Management of epileptic emergencies usually requires hospitalization and the administration of intravenous (i.v.) anticonvulsant drugs. Lorazepam i.v. is the most effective treatment of status epilepticus, and therefore is routinely used in hospital emergency departments. […]

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Modelling pollutant removal processes for an underground detention chamber system

This project will determine if underground detention systems provide an equivalent level of service for stormwater treatment as stormwater management ponds. This will be achieved through water quality measurements collected from a StormTrap system and through the development of a pollutant-transfer model. The intern will work with both the Toronto Region Conservation Authority and Con […]

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Textile Sensor Development for an EMG muscle activity monitoring system

GestureLogic is building a product that optimizes athletic performance. The product is a wearable sensory network that monitors muscle activity. The goal of this research is to take this inherently complex muscle data that is acquired by the sensory network and translate it to useful biometrics for the consumer with the help of intelligent algorithms. […]

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