There is a rapidly growing disconnect between what schools and education can provide and the conditions students need in which to be empowered in a rapidly changing world where innovation will be a necessary skill for all students to thrive in the future. This proposed research project is expected to bridge the gap between industry, […]

The University of Toronto’s Translational Research Program (TRP) is a graduate program that developed the Co-Translational Framework (CTF) to systematically mobilize research towards innovations to improve health outcomes. The Translational Research for Innovation initiative is the research mechanism to help validate the CTF to facilitate meaningful collaboration between industry and academia. Using the CTF, the […]

Idiopathic pulmonary (lung) fibrosis (IPF) affects 5 million people with a mean survival time of 2-3 years after diagnosis. In lung fibrosis, connective tissue fibroblasts excessively produce and stiffen collagen matrix. The resulting scar destroys the delicate lung architecture, decreases lung compliance and gas exchange, ultimately rendering patients unable to breathe. The only effective treatment […]

Continuous blood pressure (BP) monitor is highly beneficial for detection and prevention of stroke and cardiovascular disease. The most common BP monitor technique still relies on using a cuff that obstructs the blood flow, which is both uncomfortable and makes continuous monitoring impossible. Furthermore, research has shown that due to the numerous artifacts, the existing […]

Vaccines are one of the most important medical breakthroughs, proactively saving millions of lifes and reducing human morbidity. Yet there remains a need to make current vaccine formulations more effective and affordable, which requires testing and optimizing new formulations. In addition, there remains diseases for which there are no efficient vaccine. To develop and test […]

Implanted medical devices have dramatically improved the lives of millions of patients worldwide. However, in many cases, the body’s immune system rejects these devices and encapsulates the implant in fibrous scar tissue. This reaction is most detrimental to sensors for continuous monitoring and treatment of chronic conditions such as diabetes and those of the central […]

In the steelmaking industry, process control models need to be based on a sound physical understanding of the process but should also account for many uncertainties due to the nature and complexity of the environment in which the process is carried out. As a result, it is crucial to extract useful process control information from […]

Treatment of metastatic breast cancer is often unsuccessful and lead to 5000 deaths in Canada each year. Therefore, there is an unmet need for new drugs for prevention and/or treatment of metastatic disease. Ezrin is a protein marker commonly over-expressed in metastatic breast cancer. Preclinical studies show that blocking ezrin can significantly reduce metastasis in […]

The project will provide an opportunity to address key challenges related to user expectation of Automated and Connected Electric Shuttles. That is, the project will serve to advance the understanding of user perception and experience of smart shuttles in Canada. This technology is increasingly often being tested in pilots across Canada and it is critically […]

Over the past three decades the time it takes for clinical laboratories to diagnose an infection has decreased from two weeks for culture to 3 hours for DNA testing following the introduction of large, automated bench top equipment. Despite this tremendous improvement, three hours is still too slow to allow rapid and accurate diagnosis of […]

How can we describe and value harvesting, processing and sharing (costs as well as benefits) country foods in economic, nutritional, environmental and socio-cultural terms? How can we compare the value of country food with food that comes from other provisioning systems (e.g. imported/market-based foods and local food production)? These are important questions for both communities […]

Tooth decay (dental cavities or caries) affects over 90% of the population worldwide, however their treatment with “white” resin composite fillings yields significantly worse results than classic metallic fillings. Caries-causing bacteria penetrate the space between tooth and filling, causing further tooth decay. This damage must be treated by removing the previous filling and diseased tooth […]