Antibodies are the fastest growing segment of the pharmaceutical market, and with modern engineering technologies antibodies can be programmed to target devastating diseases. Within the immune system, antibodies fight invading bacteria and viruses. High-quality synthetic antibodies directed to disease-related targets have immense therapeutic potential. Development of cell-based assays to enable rapid identification of functionally active […]

ICES is a non-profit organization tasked with housing and conducting research of Ontario’s health administrative data. Data is available on all legal residents of Ontario, Canada most populous province. In addition, these health administrative data are being supplemented with data from other sources, such as maternal and newborn clinical data, newborn screening data, and immigration […]

Dental hygienists (DH) are exposed to many potentially injurious physical demands, such as prolonged exposure to awkward neck, trunk, and shoulder postures. The prevalence of musculoskeletal disorders in this group is alarmingly high (62-93%). DH would benefit from ergonomics-specific workplace safety education, but it is unknown what sort of instruction, if any, is currently offered […]

There is a critical need for new therapies for Parkinson’s Disease (PD), a devastating neurodegenerative disease. Current therapies for PD treat disease symptoms, but do not provide a cure. The ability to generate patient brain-derived cells may rapidly advance development of personalized therapies for PD and other incurable neurological disorders. This study will use brain […]

In human viral diseases, misbehaviour of the cellular machinery utilizing ubiquitin is frequently observed. Ubiquitin is a small protein that attaches to target proteins in human cells and signals for their destruction. Human deubiquitinases are enzymes that remove ubiquitin to keep protein levels in balance. Viral pathogens have evolved proteins that mimic human deubiquitinases to […]

This research project is intended to take the first steps forward in breeding hardier, disease resistant Atlantic salmon. Infectious salmon anemia is a disease of Atlantic salmon that has led to millions of dollars of losses within the aquaculture industry yearly on a global scale. Through a combination of genomic data and disease trial data, […]

Sensorineural hearing loss involves damage to hair cells, the sensory transducers of the auditory system, and/or the auditory neurons that transmit this information to the brain. Once these cells are lost the body does not naturally regenerate them. Elsewhere it has been shown that cells of one type may be converted into another cell type. […]

The NSERC Strategic Network for Smart Applications on Virtual Infrastructures is a five-year partnership between Canadian industry, universities, researchers, research and education  (R&E) networks, and high performance computing centres to investigate the design of future application platforms that will deliver software applications of greater capability and intelligence. These application platforms will be supported by an […]

Intimate partner violence (IPV) and sexual violence (SV) are unfortunately common occurrences in women’s lives. Women with a disability are at higher risk of these experiences. Disabilities such as depression have been researched and we now turn our attention to a condition that has not been researched: acne. This research project aims to find the […]

The intern will undertake research and development activities related to a novel functional electrical stimulation (FES) device called the MyndMove stimulator. Activities are intended to improve the electrical output of the MyndMove to deliver controlled and painless electrical stimulation to patients for a variety of applications, such as mobility, pain management and treatment of pressure […]

This project involves three streams, all focusing on the effects of low-dose ionizing radiation. The first stream examines the effects of single ion irradiation using the Microbeam at McMaster University. Preliminary biological research will be conducted on human cell lines using standard radiobiological endpoints including DNA double strand break foci and micronuclei formation. The second […]

Using surface characterization techniques, the relationship between the surface hydrophilicity level of the positive electrode and the electrochemical performance of a rechargeable aqueous battery system will be investigated. Oxygen is generated during the battery operation due to the decomposing of water, the solvent for the electrolyte, and may cover the surface of the positive electrode, […]