Health’s Wayward Sisters: An Examination of Diet, Disease, and Mortality Using a Syndemic Perspective

My proposed Mitacs-funded research will study health and disease in the medieval (11th-15th centuries AD) population from St. Peter’s Monastery in Osor, Croatia through a study of disease patterns, biochemical analysis of diet, and mortality trends. I will use syndemic theory to frame my research, which maintains that diseases and health conditions can interact with […]

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Experimental Assessment of the Optical Properties of Lanthanide-doped Upconverting Nanoparticles and their Interaction with Graphene

In the frame of this research project, lanthanide-doped nanoparticles will be synthesized that are able to convert low- to high-energy light in a process called upconversion. Given their outstanding optical properties, these upconverting nanoparticles (UCNPs) are promising candidates for applications ranging from biomedicine to optoelectronics and the energy sector. We will combine UCNPs with monolayers […]

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Polysaccharides cell wall dynamics and wall-related resistance in the cocoa (Theobroma cacao L.) / Phytophthora megakarya interaction disease

Cocoa (Theobroma cacao) is an important economical crop cultivated in tropical countries. Cocoa black pod disease, caused by Phytophthora megakarya, an oomycete, is the most economically important threat of cacao in Cameroon. Upon infection, oomycetes pathogens develop various strategies to gain access to the nutrients and eventually causing the death of the tissue, including the […]

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Caractérisation de la liaison membranaire de la rhodopsine kinase

La rétine, qui tapisse le fond du globe oculaire, est composée de plusieurs types de cellules dont les bâtonnets qui ont une structure particulière. Le segment externe des bâtonnets est composé d’un empilement de disques membranaires où est localisé le pigment visuel appelé rhodopsine. La rhodopsine change de conformation sous l’effet de la lumière, ce […]

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The role of Serotonin and the effect of SSRIs on the placental iron transport system

Depression affects up to 20% of pregnancy. If left untreated, antenatal depression increases the risk of complicated pregnancy and abnormal fetal development. The selective serotonin reuptake inhibitors (SSRIs) are the most commonly used treatment method for perinatal depression, while the risk of the drug on the placental function and fetal development remains controversial. Iron deficiency […]

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Establishment of an X-ray CT and FTIR mouse brain reference atlas

The intern will construct a 3D atlas of the mouse brain, constructed using multiple biomedical and chemical imaging techniques. The atlas will aid visualization of the 3D distribution of brain metabolites and biomolecules.. The atlas will be a powerful research and teaching resource with its multi disciplinary approach to processing and visualizing data collected at […]

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Developing a protocol for single cell Hi-C sequencing in human post-mortem brain

The purpose of the proposed research travel is to co-develop a working protocol for high-throughput chromatin conformation capture (Hi-C) sequencing using human post-mortem brain tissue at the single-nucleus level. I will be traveling to the lab of Schahram Akbarian (MD, PhD) at the Icahn School of Medicine at Mount Sinai in New York City. Dr. […]

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Sniffing Line in Mass Spectrometry for Direct Analysis

Mass spectrometry is a known for its capacity of detection of sample material with high sensitivity paired with high resolution and accuracy. Developing a “sniffing line” that would provide point-of-measurement capabilities for direct analysis of particulates on various surfaces is a necessary and novel method that will influence the mass spectrometry technique. Referred to as […]

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Multi-channel Fluidic Cartridges for Parallel Nanopore Sensing

Solid-state nanopores are tiny holes in thin membranes comparable to the size of individual biomolecules like protein or DNA. They are using as sensors to detect these molecules one at a time, and have the potential to revolutionize DNA sequencing, personalized medicine, point-of-care diagnostics, and next-generation information storage methods, but have not been able to […]

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