CT Image Optimization and Radiation Dose Reduction Strategies

  Advances in computed tomography (CT) have facilitated wider utilization and introduction of new clinical applications associated with high patient radiation dose. Subsequently, there is increasing concern for the potential long term cancer induction risks associated with increasing CT utilization bparticularly in younger women. Therefore, there is an urgent requirement to establish diagnostic CT protocols […]

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The development of short fragment SCODA (sfSCODA) for diagnostic applications.

    Emerging research indicates that a variety of short (<200 bp) nucleic acids contain a wealth of biological and medically-important information.  Two attractive sources of short nucleic acid fragments include formalin fixed embedded tissues (FFPEs) and circulating nucleic acids (CNAs) in blood. The medical value of these tissues is often limited by researchers’ ability […]

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Clinical and Economic Assessment of Vitaphone 3100 BT External Loop Recorder

  Vitaphone 3100 BT is a portable outpatient heart monitor that can be used to detect disturbances to the normal rhythmic beating of the heart (arrhythmia). Arrhythmia is associated with heart disease, heart failure and stroke. A clinical effectiveness and usability study will be conducted as well as an economic evaluation on the Vitaphone 3100 BT, and will be […]

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Intraoperative Ultrasound Calibration for Prostate Cancer Brachytherapy

Prostate cancer is the second most common cancer in North American men. Brachytherapy, applied in about 55,000 cases annually in North America, entails the permanent implantation of radioactive sources into the prostate, under real-time ultrasound image guidance. Brachytherapy systems require careful calibration to ensure the correct spatial relationship between the implant needles and the ultrasound […]

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Automated Change Detection of Serial MR Images Using Compressed Sensing

  We aim to develop a new algorithm to detect changes in serial MR examinations. Computer‐based change detection system is an important tool to automatically process abundant information produced by imaging systems and assist physicians to identify clinically important changes in the images. Many existing methods are computationally costly. The emerging mathematical theory of compressed […]

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Novel MRI Technical Developments for Noninvasive Measurements of Arterial Stiffness

  Numerous evidences have shown cardiovascular risk factors, such as high blood pressure, obesity or physical inactivity, etc, to be related to heart disease. However, some risk factors remain unclear because of technical challenges from current diagnostic tools. Hardening of the arteries, one of the potential risk factors, has been regarded as the primary indicator […]

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Manual Wheelchair Simulation with iDAPT’s CEAL Simulator

  The proposed MITACS project is intended to be a vital component of a manual wheelchair simulation project at Toronto Rehab’s CEAL Laboratory, which will re-create the experience of navigating the built environment with a wheelchair. Specifically, the internship will focus on the design and fabrication of a novel wheelchair interface that provides a person with force-feedback at […]

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Study of effect of therapeutic ultrasound device on dentoalveolar structure in dogs

  The proposed project will research the therapeutic effects of low intensity pulsed ultrasound on dentoalveolar structure on dogs.  The main research problems to be addressed by this project are: (1) study the effects of LIPUS (Low-intensity pulsed ultrasound) on the tooth root tissues (cementum and pulp) when moved orthodontically, and (2) study the effects […]

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Detection of Listeria by nanoparticle-based technology coupled with a novel fluorescence device

Listeria monocytogenes is a common food-borne pathogen that is the causative agent of listeriosis, a severe and potentially fatal condition. Current methods for detection of L. monocytogenes in food samples require multiple days due to lengthy amplification steps to aid in microbe detection. Due to the recent emergence of nanoparticle technology, however, new options are […]

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