Febrile syndromes are among the most common causes of global illness accounting for approximately two billion episodes annually. However, most infections are self-limited and only rarely do they progress to critical illness. Our current inability to rapidly identify the small proportion of individuals who will progress to life-threatening infections (LTIs) is a major barrier to […]

Despite dozens of clinical trials (and countless animal trials) to regenerate the retina with stem cells, none have solved the challenge successfully. This is because the retina has many layers, and all layers are necessary in order to restore vision in patients with advanced retinal degeneration – ~1M patients in Canada and >50M worldwide. Here, […]

This project will serve as the first formal program evaluation for the Zebra Centre, which has been serving victims of abuse in Edmonton and the surrounding area for 15 years. Program evaluation would open up opportunities for the Zebra Centre to learn about their strengths and areas of need in regards to their ability to […]

Retirement Communities (RCs) are an attractive bridge between aging-in-place/staying at home and going to full care/LTC by allowing older adults to remain independent while still receiving minimal assistance, as well as access to activities and socialization opportunities. With the mean age of residents being 85 years old, these communities offer unique insight into the future […]

The proposed project searches to understand the effect of probiotic bacterial strains belonging to the Lactobacillus and Bifidobacterium genera on the degradation and bioavailability of phenolic compounds present in potatoes (Solanum tuberosum L.) after in vitro digestion. The more easily absorbed metabolites are associated with protective effects against cancer and diabetes mellitus type II. Additionally, […]

Magnetic resonance imaging (MRI) is an imaging modality which can visualize the internal structure of the human body and is free of radiation. In this project, we would like to write a multi-functional and robust MRI software package using ultrashort echo time (UTE) technique to realize the imaging of the tissues, such as tendons, ligaments, […]

The degree of brain cell injury and death may be associated with disability and problems with memory and thinking skills in patients with multiple sclerosis (MS). This is most frequently measured by using magnetic resonance imaging (MRI) images to calculate shrinkage of brain volume. In fact, MS patients suffer more rapid shrinkage of brain volume […]

Following the study of spinal cord transected (SCT) rat models being treated by fesoterodine fumarate (antimuscarinic drug) to prevent neurogenic detrusor overactivity, bladders of all 30 animals were conserved. It was observed that an early fesoterodine fumarate administration at the time of transection modulates bladder overactivity. However, the exact mechanism of action is not known […]

Canadian children are currently not meeting the daily amount of physical activity recommended to reduce their risk for negative health outcomes. The RA Centre in Ottawa, Ontario has the resources to offer various sport opportunities to children and recognizes the need to develop programs that are developmentally appropriate and accessible for children with lower physical […]

The aim of The Ontario HIV Treatment Network (OHTN) is to help combat the spread of HIV by supporting, conducting, and sharing the best research possible. This project will involve a novel analysis examining aspects of condom negotiation among gay and bisexual men who have sex with men (GBMSM). This work is needed because the […]

Cochlear implants are surgical implanted devices that allow deaf people to recover some form of hearing and understand speech, but current devices are limited, and the consequences of these limitations have not been fully explored. For example, there is a growing consensus that hearing loss interacts with cognitive systems. Yet, relatively little is known about […]

The proposed Mitacs program will provide internships for six graduate (thesis-based MSc and PhD) students, and two Post-Doctoral Fellows (PDFs) in a competitive R&D environment at the Thunder Bay Regional Health Research Institute (TBRHRI) – Canada’s newest health research institute. Interns will be involved in research projects which aim to develop and commercialize the next […]