The promotion and maintenance of women’s pelvic floor health is a growing concern as pelvic disorders affect a substantial number of women and their prevalence is expected to increase as a result of Canada’s aging population. Pelvic floor disorders go beyond their physical consequences as they can negatively impact women’s psychological, sexual, and social quality […]

Prostate cancer will affect 1 in 7 Canadian males. While the number of therapeutic options is increasing, matching each patient to the right therapy remains as the challenge for a personalized approach to patient management. Currently, most of the attention has focused on identifying biological tags that can predict patients response. We have developed an […]

Brain natriuretic peptide (BNP) is an established prognostic marker for the early detection of heart failure. Elevated blood BNP levels are directly correlated to the severity of HF and decompensation. Current FDA approved immunoassays for BNP detection can only be carried out in medical laboratories or emergency rooms. Outpatient-use BNP monitors are yet to be […]

Cancer is a devastating disease defined by genetic changes that result in the activation of proteins that encourage cell growth or prevent cell death. Modern oncology aims to specifically target these tumour-promoting proteins, which has the secondary benefit of leaving normal cells unharmed, unlike chemotherapy. Recently, a number of drugs that specifically block tumour-promoting proteins […]

The purpose of this project is to support the development of wellness-focused interventions, including weight management, mental health and social well-being for children with intellectual and developmental disabilities (IDD). To date, the focus of health promotion interventions have primarily focused on typically developing children and adolescents, rather than those with IDD. The partner organization, Special […]

Children born with an absent or ineffective right or left ventricle (single ventricle) have a low life expectancy and will undergo at least three surgical procedures ultimately leading to the Fontan Procedure (FP), which allows blood to travel directly to the lungs (bypassing the heart) to become oxygenated. Adolescent FP-patients indicate poor cardiovascular health which […]

This study will provide the information about the in vitro bioavailability of As and Pb in SierraSil® at the first time and validate the possible product specific bioaccessibility method that can be used to predict bioavailability. This study will first compare the mineral composition of SierraSil® after acid and alkaline digestion, thus it is possible […]

Mental health is an important health issue. Adults 50 and over with a mental health concern, particularly in rural communities have unique challenges. In the South Okanagan, research found there was a lack of community services/supports available and organizations offering these services and supports did not work well together. The aim of this study is […]

As a primary cancer progresses to the deadliest form, metastatic cancer, the cells undergo several genetic and epigenetic alterations referred to as the metastatic gene signature. Part of a metastatic gene signature is the downregulation of genes associated with immune recognition, which can be seen in multiple cancer types as the down regulation of the […]

This project aims to assess a number of novel exercise training techniques to improve exercise performance in elite Canadian Wheelchair Rugby athletes. The first training technique to be assessed is training in the heat, a condition that many Wheelchair Rugby players may have difficulty competing in, to lead to adaptations that will improve performance in […]

Blood cancer (leukemia) is common, with ~48,600 and 6,400 new cases expected in the United States and Canada respectively in 2016. The National Cancer Institute (US) calculated an overall 5-year survival rate of 56% for various blood cancers. This is because most current therapies are short-lived; drug resistance and relapse pose significant clinical problems. Life-long […]

Febrile syndromes are among the most common causes of global illness accounting for approximately two billion episodes annually. However, most infections are self-limited and only rarely do they progress to critical illness. Our current inability to rapidly identify the small proportion of individuals who will progress to life-threatening infections (LTIs) is a major barrier to […]