Inhibition of the fungal-specific histone deacetylase Hst3: a novel broad spectrum strategy to fight fungal pathogens

A number of fungal pathogens cause life-threatening infections in patients whose immune system is crippled. Among others, these include patients treated with cancer chemotherapy and patients who receive organ or blood cell transportation. Pre-term infants, elderly patients and patients in intensive care units are also at risk of developing life-threatening infections. Moreover, fungi cause very […]

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High-frequency ultrasound and optical coherent tomography – application for imaging, diagnosis, and measurements on samples of soft and hard tissues

The goal of the study is to research, test and compare imaging, diagnostic, and quantitative assessment capabilities of the high-frequency ultrasound (HFU) technology and the optical coherent tomography (OCT) for dental applications. A set of samples (possibly hard and soft tissues) will be specifically prepared by the research team from the host university and then […]

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Modeling of dynamic seat and backrest adjustments for manual wheelchairs

During an average day, a wheelchair user will be required to undertake a variety of different tasks. However, wheelchairs are usually designed in a fixed configuration and cannot adapt to different situations. Models such as PDG Mobility’s “Elevation” wheelchair address this issue by allowing users to adjust their position while still seated. We aim to […]

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RF Resonant Chemical Sensor System for Biomarker Detection and Biomedical Applications

Sober Steering is developing a wearable alcohol sensor system that communicates with a vehicle to prevent drunk driving. The FitBit-style wearable device will communicate wirelessly with a Sober Steering module located behind the dash of the vehicle to provide interlock functionality and instant alerts. The wearable alcohol sensor system will be monitored and controlled by […]

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Improving signal processing in hearing aids to support music and emotional speech

Hearing aid research has traditionally focused on improving speech intelligibility for people with hearing loss, but there is increasing interest in addressing other aspects of hearing that contribute to quality of life, particularly music and other non-linguistic information. Listening to music through hearing aids is often dissatisfying due to distortions introduced by current algorithms. Hearing […]

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The Semaphorins, a role Inflammatory Bowel Diseases

Inflammatory bowel disease (IBD) includes both Crohn’s disease (CD), and ulcerative colitis (UC). Approximately 230,000 Canadians are affected by these diseases and they have important repercussions on quality of life and on both personal and societal direct and indirect costs. The cause(s) are poorly understood, and treatment is largely symptom-based and not curative. Commonly used […]

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Technology to improve walking competency in seniors

Walking pattern in healthy adults changes with age. A poor walking pattern results in fall and fear of falls. It is important to detect early changes in gait so that corrective measures are taken. In this project I am planning to use a sensor (Heel2Toe device) that detects when an individual makes a correct step […]

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Mitigating the risks associated with radio-frequency cardiac ablation

A cardiac arrhythmia is defined as an abnormal heartbeat which happens when the patient’s heart beats too fast, too slow, or in other irregular patterns. Although arrhythmia can occur without any symptoms, it is typically associated with heart palpitations, chest pains, fainting or heart failure. One type of treatment option is an interventional catheter-based procedure, […]

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Looking at the Physical and Psychosocial Outcomes of an After-School Physical Activity Intervention for Children with Congenital Heart Disease

The research intern will be working with Sportball to offer one of their multi-sport after-school programs to children who are living with serious heart defects. Physical activity has many health benefits for children, and after-school programs are an effective way to increase daily physical activity levels. Children living with heart disease are a vulnerable group […]

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