Functional magnetic resonance imaging (fMRI) is a noninvasive technology for examining functional activity in the brain. It is widely used in research, but is not yet part of routine patient care in clinics. To date, most of the fMRI applications collect imaging data at a single time point. This has limited the potential of the […]

Streptococcus agalactiae (S. agalactiae) is a worldwide-distributed bacterium. It is a major infectious agent to humans, cattle and aquatic animals. The outbreak and prevalence of S. agalactiae in aquaculture has been reported in different countries as one of the major causes of mortality leading to serious economic losses and threatening the sound development of aquaculture. […]

Ce projet a pour but de proposer aux gestionnaires des centrales hydro-électriques d’Hydro-Québec des solutions d’organisation de la maintenance de turbine hydro-électrique à partir d’un indice prédisant l’état futur de la turbine. Cette organisation prendra en compte plusieurs aspects tels que la problématique liée à la demande en énergie (certaines périodes sont plus propices que […]

In human viral diseases, misbehaviour of the cellular machinery utilizing ubiquitin is frequently observed. Ubiquitin is a small protein that attaches to target proteins in human cells and signals for their destruction. Human deubiquitinases are enzymes that remove ubiquitin to keep protein levels in balance. Viral pathogens have evolved proteins that mimic human deubiquitinases to […]

In human viral diseases, misbehaviour of the cellular machinery utilizing ubiquitin is frequently observed. Ubiquitin is a small protein that attaches to target proteins in human cells and signals for their destruction. Human deubiquitinases are enzymes that remove ubiquitin to keep protein levels in balance. Viral pathogens have evolved proteins that mimic human deubiquitinases to […]

Gene therapy is one of the most attractive new therapeutic strategies in the treatment of multiple diseases. However, to apply gene therapy in clinic, an efficient and safe delivery system must be developed to transport these therapeutic reagents to target organs. The existing gene carriers suffer from either high cytotoxicity or immunogenicity problems, which will […]

Gene therapy is one of the most attractive new therapeutic strategies in the treatment of multiple diseases. However, to apply gene therapy in clinic, an efficient and safe delivery system must be developed to transport these therapeutic reagents to target organs. The existing gene carriers suffer from either high cytotoxicity or immunogenicity problems, which will […]

Post-traumatic stress disorder (PTSD) emerges after the exposure to an event that elicits horror or helplessness, including threat of injury or death to one’s self or another person. Community-based studies have evaluated its occurrence with a lifetime prevalence of 9.2% in the Canadian population. This research project aims to develop innovative, neural-substrate based, and novel […]

Future broadband cellular systems will require very high throughput data transmission to satisfy ever increasing demands of mobile users for high speed multimedia services. Using innovative approaches to multiantenna transmission/reception and to cooperation of network nodes the achievable data rates can be greatly increased. Two significant obstacles to achieving very high data rates are interference […]

Non-small cell lung cancer is the leading cause of cancer deaths worldwide. Resistance to treatments results in a very poor long-term prognosis. VAL-083 is a chemotherapeutic drug that has activity against lung cancer in cell-studies and in clinical trials. It may be an effective treatment option for drug-resistant lung cancer. However, the detailed mechanism of […]

Antibodies are the fastest growing segment of the pharmaceutical market, and with modern engineering technologies antibodies can be programmed to target devastating diseases. Within the immune system, antibodies fight invading bacteria and viruses. High-quality synthetic antibodies directed to disease-related targets have immense therapeutic potential. Development of cell-based assays to enable rapid identification of functionally active […]

The goal of this project is to develop the first ever high definition integrated water circulation and water quality model for the Toronto Waterfront. As one of the most urbanized freshwater ecosystems with complex geometries and physical processes, Toronto Waterfront is in an urgent need for modern scientific tools that can support effective environmental management […]