Innovative Projects Realized

Explore thousands of successful projects resulting from collaboration between organizations and post-secondary talent.

30508 Completed Projects

2882
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5105
BC
825
MB
681
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860
SK
9051
ON
9491
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97
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586
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1141
NS

Projects by Category

Mucoadhesive and mucopenetrative micelle formulation for anterior segment ocular drug delivery

While eye drops are the most common treatment for anterior segment ocular disorders, they are inefficient due to fast clearance, often requiring frequent and high doses, reducing patient compliance, and increasing the risk of systemic toxicity. To improve the efficiency and efficacy of topically applied therapeutics, a drug-loaded polymeric micelle that interacts with the mucin layer of the eye has been developed. These micelles have been formulated with a mucoadhesive moiety that can interact with the mucin layer of the tear film, increasing the residence time of the drug-loaded micelles on the surface of the eye. This increased residence time will reduce the frequency and concentration of dose administration, which leads to improved patient compliance and treatment outcomes. This formulation has a charged moiety that reduces drug compatibility. A new formulation has been proposed that replaces the charged component with a mucopenetrative component, that, in combination with the mucoadhesive moiety, can penetrate deeper into the mucin layer before adhering, further increasing the residence time. This research will focus on the characterization of these mucin interactions and the assessment of corneal drug penetration, as well as compatibility with ocular tissue assessments.

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Faculty Supervisor:

Heather Sheardown

Student:

Partner:

University of Auckland

Discipline:

Engineering

Sector:

Nanotechnology; Pharmaceuticals; Health and Related Sciences & Technology

University:

McMaster University

Program:

Globalink Research Award

Physiological changes throughout menopause

The risk of heart disease in women is underestimated, however once women enter menopause there is a large increase in disease risk, with heart disease accounting for ~75% of deaths in postmenopausal women. However, the full bodily changes that women experience during, and in the time after menopause is not understood. Additionally, it is well-known that exercise is effective in preventing mortality, however whether exercise can reduce negative changes that occur in menopause is unknown. Therefore, the purpose of this study is to understand both the physiological changes that women experience during menopause, and the influence of exercise. This study will recruit 200 women and include measures of muscle, brain, cardiovascular, and arterial health before beginning menopause, at the onset of menopause, and three years following menopause. This ongoing research study is led by Dr. Hellsten, an established researcher in the field of cardiovascular physiology and the head of the August Krogh Section for Human Physiology at the University of Copenhagen. Dr. Hellsten explores techniques that are closely related to, but distinctive from those in my PhD studies at McMaster, therefore I will be able to apply these skills to future work in my home laboratory, at McMaster.

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Faculty Supervisor:

Maureen MacDonald

Student:

Partner:

University of Copenhagen

Discipline:

Life Sciences

Sector:

Education

University:

McMaster University

Program:

Globalink Research Award

Approche multifilières de traitement des déchets multisectorielsassociés à un territoire: étude de cas de la région de Xalapa (Mexique) 2

Le projet vise à élaborer et proposer des solutions intégrées à la problématique de gestion des déchets pour un territoire dans le région de la ville de Xalapa (Mexique). Pour cela, le projet prévoit deux stages : (1) mise en valeur agricole des matières résiduelles organiques et en particulier des résidus du secteur du café (secteur d’importance pour la région); (2) proposition d’un plan de gestion des déchets pour le territoire, considérant la diversité des déchets et des filières de traitement potentielles. L’approche générale proposée vise à maximiser la mise en valeur des matières résiduelles en les considérant comme une ressource. Dès lors, comme tout gisement, il s’agit de : (i) caractériser et localiser les matières disponibles sur le territoire; (ii) identifier des filières de valorisation et des scénarios d’implantation; (iii) mettre en place un processus d’aide à la décision qui s’appuie sur des essais pilotes en laboratoire et une méthode d’analyse multicritères.

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Faculty Supervisor:

Mathias Glaus

Student:

Partner:

Universidad Veracruzana

Discipline:

Engineering

Sector:

Education

University:

École de technologie supérieure

Program:

Globalink Research Award

Développement et mise en œuvre d’un protocole pour l’utilisation de capteurs de qualité de l’air, pour la mise en lien environnement et santé.

This research project focuses on understanding climate change’s effects on air quality and human health. It acknowledges that exposure to chemical and physical stressors also increases as extreme environmental events (like heatwaves, floods, droughts, …) become more frequent. This could potentially lead to new adverse health impacts or amplify existing ones.
The project’s primary objective is to develop a method to monitor and predict the spatiotemporal dynamics of environmental health at a local scale, using a combination of high-performance multimodal sensors and low-cost mobile sensors. Data processing algorithms will be applied to correct inaccuracies, interpolate data, and predict environmental conditions over time and space scales.
The project’s first phase focuses on developing the multimodal sensors station. This will be the goal of an internship at the Interdisciplinary Institute for Technological Innovation (3IT) at Université de Sherbrooke. The internship will involve developing and deploying portable multimodal instrumentation for collecting and monitoring the physicochemical parameters of a given region. Over the course of the 24-week internship, a series of sensors will be controlled to monitor environmental parameters such as temperature, relative humidity, COV, particulate matter (PM1, PM2.5, PM10), odor, and sounds. The sensor station will then be tested in several controlled environments.

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Faculty Supervisor:

Denis Machon

Student:

Partner:

Université Paris-Saclay

Discipline:

Engineering

Sector:

Education

University:

Université de Sherbrooke

Program:

Globalink Research Award

Portrait d’entreprises innovatrices en développement et en gestion de logements sociaux et abordables hors marché au Québec

Ce projet vise à réaliser une étude de cas sur 3 entreprises québécoises : Interloge, UTILE et Mission Unitaînés. Ces cas décriront leur mode particulier de gouvernance et d’organisation en entreprise collective ainsi que leurs modèles d’affaires alternatifs et innovateurs en développement et en gestion de logements hors marché destinés à répondre aux besoins particuliers de différents types de clientèles (familles et à faibles revenus, personnes à mobilité restreinte, personnes en perte d’autonomie, étudiant.e.s, aîné.e.s, etc.). Ces modes de gouvernance à but non lucratif, combinés à la mise en oeuvre d’un modèle d’affaires intégrant la conception, la construction et l’opération d’immeubles locatifs, ont pour effet de maintenir les coûts et les loyers accessibles et de placer les propriétés à l’abri du marché spéculatif. Nous étudierons comment ces modes permettent de gérer les coûts et les loyers des logements en examinant les processus de gestion des coûts de construction, d’opération et de gestion de logements. Il ne suffit pas que de réduire les coûts mais aussi d’offrir des logements durables et résilients : ces critères associés au concept de bâtiment durable et à celui des impacts sur leurs usagers et leur voisinage seront aussi analysés.

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Faculty Supervisor:

Andrée De Serres;Hélène Sicotte

Student:

Partner:

Inter-loge Centre-Sud;Unité de travail pour l’implantation de logement étudiant;Mission Unitaînés

Discipline:

Business

Sector:

Real estate and rental and leasing

University:

Université du Québec à Montréal

Program:

Accelerate

Development and Ground Truthing AI-based models of Seaweed Cultivation in Relationship to Environmental Nitrogen Availability

Seaweed aquaculture is an important and increasingly large part of the global economy, and, more recently, a potential solution to combat climate change. The element nitrogen is a key limiting resource for the growth of marine plants, including seaweed. Tracing and modeling nitrogen in the environment is challenging at large scales and requires substantial computational power under classical paradigms and approaches. Artificial intelligence-based approaches offer a potential solution in being able to model environmental nutrient cycling and approximate seaweed growth, but at a fraction of the cost of standard computational approaches. Our work aims to apply artificial intelligence-based models to nitrogen cycling in the environment to better constrain and estimate seaweed growth in complex environments.

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Faculty Supervisor:

Carly Buchwald

Student:

Partner:

Coastal Carbon

Discipline:

Earth science

Sector:

Professional, scientific and technical services

University:

Dalhousie University

Program:

Elevate

Modélisation des comportements des fluides environnementaux et du système respiratoire chez l’humain (avec ou sans contaminant; avec ou sans traitement)

Modélisation des comportements des fluides environnementaux et du système respiratoire chez l’humain (avec ou sans contaminant; avec ou sans traitement) (ex, : O2))

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Faculty Supervisor:

Louis Dufresne

Student:

Partner:

École Nationale Supérieure de Mécanique et d’Aérotechnique

Discipline:

Engineering

Sector:

Artificial Intelligence; Health and Related Sciences & Technology

University:

École de technologie supérieure

Program:

Globalink Research Award

Development of Transparent Collagen Fiber Scaffolds for Corneal Tissue Engineering

The cornea is a thin transparent tissue that protects the internal parts of the eye and refracts light onto the retina. Severe corneal damage can lead to irreversible scarring that prevents light from passing through the cornea, causing long-term vision loss. The best treatment for severe corneal damage is to transplant donor corneal tissue from a cadaver. Unfortunately, donor corneas are not always available when patients need them. Thus, many patients experience permanent vision loss while they wait for corneal transplantation. A treatment that does not rely on donor corneal tissue and that can be given immediately after corneal injury has potential to prevent scarring in these patients so that they do not lose their vision. This unmet clinical need will be addressed by a new biomaterial technology developed in the Frampton Lab capable of producing aligned collagen fibers that mimic the structure of the cornea. This collagen-based biomaterial textile will serve as a corneal patch for repairing corneal damage without the need for donor corneas. This project will seek to better understand the properties of collagen-based fibers that lead to a textile patch with high transparency to visible light.

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Faculty Supervisor:

John Frampton

Student:

Partner:

HAN University of Applied Sciences

Discipline:

Engineering

Sector:

Education

University:

Dalhousie University

Program:

Globalink Research Award

Approche multifilières de traitement des déchets multisectorielsassociés à un territoire: étude de cas de la région de Xalapa (Mexique)

Le projet vise à élaborer et proposer des solutions intégrées à la problématique de gestion des déchets pour un territoire dans le région de la ville de Xalapa (Mexique). Pour cela, le projet prévoit deux stages : (1) mise en valeur agricole des matières résiduelles organiques et en particulier des résidus du secteur du café (secteur d’importance pour la région); (2) proposition d’un plan de gestion des déchets pour le territoire, considérant la diversité des déchets et des filières de traitement potentielles. L’approche générale proposée vise à maximiser la mise en valeur des matières résiduelles en les considérant comme une ressource. Dès lors, comme tout gisement, il s’agit de : (i) caractériser et localiser les matières disponibles sur le territoire; (ii) identifier des filières de valorisation et des scénarios d’implantation; (iii) mettre en place un processus d’aide à la décision qui s’appuie sur des essais pilotes en laboratoire et une méthode d’analyse multicritères.

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Faculty Supervisor:

Mathias Glaus

Student:

Partner:

Universidad Veracruzana

Discipline:

Engineering

Sector:

Education

University:

École de technologie supérieure

Program:

Globalink Research Award

Dissecting the role of Arabidopsis Glutamine Dumper transporter

Plants face various pathogen challenges. Pathogen infection can not only trigger local defence responses to restrict pathogen growth at the primary infection sites, it can also induce plants to generate mobile signals, which move to the uninfected tissue to protect them from further pathogen attack. This primed immunity is called systemic acquired resistance (SAR). A SAR defective mutant fmo1 was identified for a long time, whereas its function was uncovered recently to be an enzyme generating a novel molecule called N-hydroxy-pipecolic acid (NHP). External application of NHP on the root of fmo1 could be detected in distal leaves and restore the SAR defects of fmo1, which suggests that NHP or its derivatives may act as the SAR mobile signal. However, it is unclear how NHP or its derivatives is transported. Considering that NHP is an amino acid metabolite and is derived from Lysine, we hypothesized that the non-selective amino acid transporter Glutamine dumpers (GDUs) may play some roles in NHP or its derivatives transport. In my PhD, I did reverse genetic study of the GDU family. We generated the gdu1/2/3/4 quadruple mutant and its SAR response was a bit suppressed, which suggests that GDUs may have function in regulating SAR. For my exchange, I hope to answer the question what signal(s) are transported by GDUs in SAR. We plan to do the non-targeted metabolomics analysis of the phloem extrudates of GDUs to see if there is any NHP or NHP derivatives. If some new NHP derivative is found, we can design feeding experiment to test its function in SAR. This will further our understanding of the role of NHP in SAR.

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Faculty Supervisor:

Xin Li

Student:

Partner:

Georg-August-Universität Göttingen

Discipline:

Life Sciences

Sector:

Education

University:

The University of British Columbia

Program:

Globalink Research Award

Adaptation cardiovasculaire et perspective temporelle

Le vieillissement de la population pose des défis majeurs. Le nombre croissant de cas de démence liée à l’âge souligne la nécessité de mieux comprendre le vieillissement pour prévenir le déclin cognitif. Ce projet propose d’utiliser la variabilité de la fréquence cardiaque (VFC) et la perspective temporelle comme indicateurs pour prévoir et influencer positivement le vieillissement. La perspective temporelle, perception du temps restant à vivre, est associée à la santé et à la gestion du stress. Une perspective temporelle limitée est liée à une mauvaise santé. La VFC, qui mesure la variation entre les battements cardiaques, indique un bon état de santé et un faible stress physiologique. Ce projet explore le lien entre VFC et perspective temporelle, en se basant sur l’idée que la VFC peut être améliorée par des exercices de respiration, avec des effets positifs sur le stress et les fonctions cognitives. Pour tester ces hypothèses, des participants de plus de 60 ans et des jeunes adultes seront recrutés pour évaluer leurs capacités cardiovasculaires (VFC) et leur perspective temporelle. Les résultats pourraient ouvrir la voie à des interventions simples pour améliorer la santé cognitive et affective des personnes âgées.

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Faculty Supervisor:

Guillaume Vallet

Student:

Partner:

Université Bourgogne Europe

Discipline:

Sociology

Sector:

Health and Related Sciences & Technology; Other

University:

Université du Québec à Trois-Rivières

Program:

Globalink Research Award

Effects of Enhanced Efficiency Nitrogen Fertilizers on the Agronomic and Environmental Performance of Grain Corn in Maritime Canada

The proposed project will investigate different nitrogen fertilizers in grain corn including products developed to release nitrogen more closely with when the crop demand is higher to reduce environmental impact. Results from the project will provide recommendations to growers regarding the best type, and the optimum rate and nitrogen split application timings of EENFs in grain corn, and help improve food security and the overall sustainability of the agricultural industry. The Atlantic Grains Council (AGC) works together with industry, academic, and public research institutions to address knowledge gaps that could improve the sustainability of the agricultural industry in Atlantic Canada to help mitigate the impacts of climate change. The connection between the AGC and the industry provides the intern with knowledge of what producers and other industry members would like research to focus on, which in return benefits the AGC by providing results that could benefit industry partners. The current project aims to reduce environmental impact from nitrogen fertilizers using enhanced efficiency nitrogen fertilizers (EENFs) and assist in meeting the AGC’s goal of improving agricultural sustainability and improving the industry overall, and allow the AGC to provide information to the industry on the most sustainable fertilizer practices.

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Faculty Supervisor:

Yunfei Jiang

Student:

Partner:

Atlantic Grains Council

Discipline:

Life Sciences

Sector:

Agriculture

University:

Dalhousie University

Program:

Accelerate

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Mitacs is funded by the Government of Canada, the Government of Alberta, the Government of British Columbia, Research Manitoba, the Government of New Brunswick, the Government of Newfoundland and Labrador, the Government of Nova Scotia, the Government of Ontario, Innovation PEI, the Government of Quebec, the Government of Saskatchewan, and the Government of Yukon.