Skeletal muscle is a dynamic tissue that undergoes many regeneration processes during our lifetime. Loss of skeletal muscle is known as muscle atrophy or sarcopenia and is directly related with quality of life and life expectancy. There are very few diagnostic tools to identify muscle atrophy and the ones available are time-consuming and expensive. Therefore, […]

The lymphatic system serves an integral role in fluid homeostasis, lipid metabolism and immune control of the human body. Lipid based nano-carriers employing lymphatic voyage offer multitude of advantages like enhanced bioavailability, selective targeting to localized as well as metastatic conditions, controlled delivery and others. Lipid-based nano-carriers have been tested on various experimental various in-vivo, […]

Ribosome biosynthesis is one of the most multifaceted and energy-demanding processes in biology. It involves over 250 factors that transiently associate with the nascent pre-ribosome in a well-orchestrated manner. Importantly, increased ribosome biogenesis has a critical role in cancer initiation and progression. Owing to the advances in cryo-electron microscopy, this pathway’s detailed mechanism started to […]

Our aim is to use machine-learning to improve treatment of post-surgical pain in children and adults. Most people addicted to opioids were initially exposed through the treatment of pain from trauma and/or surgery. The opioid crisis is reaching the pediatric population, in whom effective post-surgical pain management, with less reliance on prescription of opioids, is […]

New evidence about psychedelic remedies has increased the number of patients who potentially can benefit from therapies using these drugs. In clinical trials worldwide, the findings are reported on psychedelic medications for treating illnesses such as addiction, depression, anxiety, and mental health conditions like post-traumatic stress disorder (PTSD). If psychedelic drugs are orally administered, the […]

The new regulations for pharmacies had catastrophic consequences for the ability of normal pharmacies to compound prescribed preparations for patients using drug powders. Most pharmacies have stopped to offer compounding services at all. This leaves a gap in the ability to provide timely access to needed medicines. The proposed research work will develop an individually […]

Pharmacists are providing increasingly patient-centered clinical services such as Pharmacists Prescribing for Minor Ailments (PPMA). However, several factors delay pharmacists’ ability to implement PPMA including integration with workflow and time constrains. Technology solutions aim to support PPMA can be important innovative tools to help pharmacists to perform PPMA. The aim of this project is to […]

Gene therapy has the potential to effectively treat a wide range of ocular disorders. However, the introduction of foreign therapeutic genes to cells is incredibly challenging. Compared to viral vectors, non-viral vectors (NVV) are far less immunogenic and less toxic. However, NVV are less efficient than viral vectors at delivering therapeutic genes because they must […]

Schizophrenia is a complex neurodevelopmental disorder that affects approximately 1% of the population worldwide. Although research on schizophrenia is ongoing, little is still known about its origin. Schizophrenia is thought to result from a combination of genetic and environmental factors that ultimately lead to decreased brain volume and cortical thickness changes in energy metabolism or […]

Pharmaceuticals are among the most commonly used and important healthcare treatments in Canada. Third party healthcare payers, such as provincial departments of health and private insurers such as Blue Cross and Green Shield, use a variety of tools and techniques to balance the access, cost and quality of medications. Collectively, these tools and techniques are […]

In partnership with Labopharm, a leading company in optimizing the performance of small molecule drugs, a complete pharmacokinetic (PK) study of three new formulations of a commercially available drug will be performed. This study will be conducted in order to choose the most appropriate formulation in terms of bioavailability and absorption rate. Pharmacokinetics parameters of […]

Amphotericin B is the most effective, and frequently the only treatment available for a number of life-threatening diseases, including systemic fungal infections and visceral leishmaniasis. The drawbacks of today’s amphotericin B treatment are toxicity and the need to administer the drug intravenously in hospital settings. The need for intravenous administration is due to poor absorption […]