Harm reduction-based programming and services for people living with HIV/AIDS (PLHIV) in a novel clinical care setting: the opportunities and challenges for clinicians, clients, donors and fundraisers

Substance use significantly impacts the health and health care of many people living with HIV/AIDS (PLHIV), especially those dealing with additional medical, psychosocial, and economic complications. The need for comprehensive care for this population is particularly important given the current opioid overdose crisis in Canada. In response, harm reduction (HR) services (e.g., supervised injection, naloxone […]

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Multi-agent reinforcement learning for decentralized UAV/UGV cooperative exploration

Over the last decade, artificial intelligence has flourished. From a research niche, it has been developed into a versatile tool, seemingly on route to bring automation into every aspect of human life. At the same time, robotics technology has also advanced significantly, and inexpensive multi-robot systems promise to accomplish all those tasks that require both […]

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Development of nanoparticle in vivo labeling contrast probes for tissue clearing 3D microscopy compatible with multi-modal imaging in fluorescence, dark field, MRI, CT and electron microscopy modalities.

High resolution 3D microscopy in combination with tissue clearing techniques such as CLARITY, iDISCO, CUBIC is a rapidly growing area of biomedical research. It also has high potential to replace traditional 2D histology to become a method of choice for the analysis of tissue biopsy samples used in diagnosis of cancer and other diseases. However, […]

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Program evaluation for JUMP Math: An empirical assessment of a resource for math education

Canadian math scores are in decline. Numerous studies have demonstrated the importance of numerical proficiency for outcomes such as health, employability and financial stability. Therefore, the effectiveness of a child’s math education is key to future success. It is of utmost importance, then, to identify effective math education programs. The proposed project will evaluate JUMP […]

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Development of a personalized in-vitro model for dystrophic muscle endogenous repair for drug discovery

Duchenne muscular dystrophy (DMD) is a genetic disorder resulting in progressive muscle degeneration. Satellos Bioscience Inc is developing small molecule drugs that target and modulate DMD muscle stem cells to repair the dystrophic muscle. Despite the advantages of DMD animal models, they are not always predictive of human DMD phenotypes, or their response to drug […]

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Formulating a novel goat-whey based drink and studying its nutritional and health functions – Year two

This project will create novel goat milk-based products and test their health effects in healthy adults. Interest in goat milk is increasing, mainly due to two market trends: consumers’ new taste trends for niche/ethnic products, and the perception of goat milk having added health properties. Goat milk is perceived as having intestinal anti-inflammatory effects and […]

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Root associated microbiome of trees growing in a fractured bedrock toluene phytoremediation site

Phytoremediation is a promising in-situ technology that uses plants and its associated microorganisms (particularly bacteria and fungi) to clean up contaminated soils. The efficacy of these processes however, requires an in-depth knowledge on the diversity of microbial communities closely interacting with plant roots. Several studies have demonstrated that plants growing in contaminated soils select for […]

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Simeio: Anomaly Detection for Building Automation System

Buildings are an important energy consumer and are equipped with hundreds of sensors and control systems. The analysis of such massive data can reveal insights for building owners to optimize the building infrastructure. Currently, usage of such data is limited to traditional control systems, energy commissioning, and maintenance on a regular basis. Real-time monitoring and […]

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Smart Work Zone Management

Construction zones are one of the leading contributors to Toronto’s ever-growing congestion. The aim of this study is to develop an integrated construction zone traffic management framework to minimize disruption of the traffic and reduce the effect in terms of congestion. This study leverages historical and real data collected from on-board construction trucks provided by […]

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Computational Chemistry And Structural Biology Approaches To Tackle Huntington’s Disease

Huntington’s Disease (HD) is a fatal hereditary neurodegenerative disease caused by expansion of the CAG repeat tract at the 5’ of the huntingtin (htt) gene resulting in polyglutamine expansion of the HTT protein (polyQ-HTT) of aberrant function. HD symptoms include loss of motor coordination, cognitive and speech impairment, and psychiatric disorders. HD affects approximately 1 […]

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