Dopamine and noradrenaline are neurotransmitters that are released from neurons located in the substantia nigra and locus coeruleus. Therefore, these brain structures have the unique property of containing high concentrations of neuromelanin, a dark pigment that can be visualized with specialized MRI sequences. The neuromelanin-sensitive MRI signal has been used to visualize degeneration of these […]

Effective wastewater treatment is essential to the health of the environment and municipal wastewater treatment plants in Canada are required to achieve specific effluent water quality goals to minimize the impact of human generated wastewater on the surrounding environment. Most wastewater treatment plants include a combination of physical, chemical, and biological unit processes and therefore […]

Imaging of cerebral perfusion (the delivery of blood to a capillary bed in the brain tissue) is significant for diagnosing a variety of diseases. There are multiple challenges associated with perfusion imaging which significantly limits the quality of cerebral perfusion images. I am planning to develop a novel approach of cerebral perfusion magnetic resonance imaging […]

The global burden of hepatocellular carcinoma (HCC) is increasing as it has become the second leading cause of cancer-relateddeaths and the fifth most common cancer worldwide. HCC is heterogenous, arising in the setting of various chronic liver diseasessuch as hepatitis C, non-alcoholic fatty liver disease and cirrhosis. Patients with cirrhosis who develop cancer cannot tolerate […]

This project is on system and algorithm design for motion control and coordination in a vehicle team composed of one ground vehicle (GV) and one or multiple cooperating unmanned aerial vehicles (UAVs). The GV here is either an advanced light armored vehicle (LAV) or an all-terrain unmanned GV (UGV) to traverse a cluttered off-road terrain […]

Yukon River Chinook salmon have experienced devastating declines in recent years, leading to significant impacts on Yukon First Nation citizens. To address this growing conservation issue, we have collaborated with Yukon First Nations to understand their desires for improving salmon conservation capacity, and how we can support them in this endeavour. Together, we have identified […]

Ribosome biosynthesis is one of the most multifaceted and energy-demanding processes in biology. It involves over 250 factors that transiently associate with the nascent pre-ribosome in a well-orchestrated manner. Importantly, increased ribosome biogenesis has a critical role in cancer initiation and progression. Owing to the advances in cryo-electron microscopy, this pathway’s detailed mechanism started to […]

The COVID-19 pandemic has illustrated the need for the development and commercialization of enhanced personal protective products, air filtration systems, and high-touch surface coatings which supplant residual disinfection and render viruses inert. The pandemic has also highlighted the need for local supply-chain establishment, including antiviral coating manufacturing and materials sourcing in Canada. This proposal is […]

In Canada, over 30% of adults and 10% of children are affected with non-alcoholic fatty liver disease (NAFLD), a chronic condition often related to obesity. NAFLD refers to a range of conditions related to excess fat in the liver, unrelated to alcohol intake. NAFLD is a precursor to liver cirrhosis, end stage liver disease and […]

IN_SITU is a research study that investigates the possibilities and challenges of connection and bridge-building between Canadian arts sectors and the most advanced academic research centres dealing with Artificial Intelligence in Canada and beyond. The study will explore how artists and artistic organizations can augment their digital strategies, literacy and intelligence when artists co-create with […]

Accidental fisheries catch ? or bycatch ? is a critical issue for conservation and fisheries management. Greenland sharks are a common bycatch in northern fisheries and are of concern because they are long-lived and may be vulnerable to overfishing. The proposed research addresses current data gaps related to Greenland shark bycatch through the following objectives: […]

The proposed research seeks to learn more about the ways Sponsorship Agreement Holders (SAHs), collaborate with Constituent Groups (CGs) and Co-sponsors to sponsor refugees to resettle in Canada. For this project, the Canadian Unitarian Council (CUC), will be used as a case study. Given the limited capacity and resources that SAHs have available to them […]