Some diseases and brain injuries can seriously impair language. Patterns in an individual’s speech can allow computers to describe these impairment with a high degree of accuracy. These techniques can be used to test large groups of people for drug trials and potentially replace pen-and-paper based testing methods. To fully automate this process, speech recognition […]

Simulation is being used increasingly to improve medical education by providing students and trainees with greater access and opportunity to learn critical skills without affecting actual patient care. To this end, OtoSim has developed a multi-user training platform and an otoscope tracking device. The multi-user training platform allows the trainee to self-learn while being electronically […]

Memory impairment is the most common cognitive complaint among older adults. On the other side of the developmental spectrum, young adults that have been diagnosed with Autism Spectrum Disorders (ASD) have difficulty adapting flexibly to changing social circumstances. These memory and social deficits disrupt every day living. At present, promising interventions based on research using […]

The analysis of protein-protein interactions is critical for understanding cell growth control, and how aberrant connections contribute to cancer and other diseases. Mass spectrometry is a critical tool in this field, but sample complexity, instrument dynamic range and resolution limit some applications. This project will evaluate the use of the SelexION ion mobility device and […]

The bacterial transferrin receptor is considered to be a potentially efficacious candidate vaccine antigen against pathogens important in human disease and in animal husbandry. Previous data suggests that transferrin receptor-based antigens can elicit protection from both invasive disease and potentially from asymptomatic colonization. One major consideration when developing vaccines is the choice of adjuvant, a […]

Wildland fire fighting is a physically demanding public safety occupation. Front-line wildland fire fighters (WFF) must have an appropriate level of job-related fitness for safe and efficient work performance. Beginning in 2011, it was required that all WFF must demonstrate that they are capable of meeting the rigorous physical demands encountered during an initial attack […]

It is well known that an adequate and stable income promotes health. Material security (e.g., housing, food, and service access) may operate distinctly from income security, yet may also be critically important to health. Nevertheless, material security and its relationship with employment is not well understood, an important oversight in research among people who use […]

Medication used everyday to help cure various diseases, or even alleviate pain, ends up in the sewage system due to the less than perfect consumption of these medicines in the body and excretion of the unused portion. These compounds eventually find their way to the environment since the current treatment methods in wastewater treatment plants […]

Community leadership development and training programs must respond to changing corporate and public perceptions. There has been a lack of research on community leadership within small urban settings, where the impact that training and development programs have may be high. Our objective is to describe how local businesses in a small urban setting understand community […]

This project aims at evaluating whether recent results in deep learning models, trained to exploit weak labels (Hwang, 2016) can serve to extract meaningful lesion localizations from image-level labels, either from individual scans or given a (longitudinal) sequence thereof. To this end, we will scale up existing models that have been shown to work on […]

The project aims to translate developments in ultra-sensitive MRI sensors to a clinically-relevant setting. To create high-sensitivity sensors for better images, we aim to create a tight-fitting system which places the sensors—akin to antennas—closer to the brain. This will improve the quality of the signals that we can extract from the brain, and allow us […]

Cyclin-dependent kinase-2 (CDK2) regulates cell cycle, whose structure and biological characteristics are well known. CRIF1 plays a regulatory role in the bone marrow microenvironment-induced leukemia cell cycle arrest through inhibiting CDK2. In this multi-disciplinary research, we will use a combined structure function study to reveal the interaction between CDK2 and CRIF1. This will facilitate the […]