Innovative Projects Realized

Explore thousands of successful projects resulting from collaboration between organizations and post-secondary talent.

29670 Completed Projects

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Projects by Category

Studies on the Biosynthesis of Nucleocidin in Streptomycetes

Approximately 80% of currently used antibiotics were first discovered from Streptomyces. In addition, many pharmaceuticals, including antibiotics, are halogenated. In particular about a quarter of the top-selling pharmaceuticals are fluorine-containing compounds. The overall objective of my doctoral thesis is to elucidate the complete biosynthetic pathway of the fluorinated antibiotic, nucleocidin, in Streptomyces. Elucidating the biosynthesis of nucleocidin, will be greatly advantageous in helping future research in finding new fluorinated and bioactive natural products through genome mining. As well, the nucleocidin fluorinase can be developed for applications in fluorinating pharmaceutical compounds, offering a greener and more specific alternative to synthetic fluorination methods. My PhD thesis has four goals: 1) Identification of new and higher titre Streptomyce producers of nucleocidin, 2) Identify the minimal set of genes in Streptomyces necessary for nucleocidin biosynthesis, 3) characterize the encoded enzymes that synthesize the sulfamate moiety, 4) characterize the encoded enzyme(s) which catalyze fluorination. During this internship, I will focus on completing the second goal. I have identified key genes to focus on for gene disruption experiments to determine which genes in Streptomyces are necessary for nucleocidin biosynthesis.

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Faculty Supervisor:

David Zechel

Student:

Partner:

Albert-Ludwigs-Universität Freiburg

Discipline:

Life Sciences

Sector:

Education

University:

Queen's University

Program:

Globalink Research Award

Immunomodulating fusion protein (CT001) to treat solid malignancies

Cura Therapeutics is developing innovative immunotherapies to cure solid malignancies and infectious diseases. Cura Therapeutics immunotherapy platform simultaneously activates the immune response against cancer while disrupting the tumor blood supply. These immunotherapies also induce an immunological memory that prevent cancer recurrence. Currently, there are no treatments on the market or in clinical trials that combine these properties in one single therapy. The objective of this project is to complete the preclinical stage of Cura Therapeutics’ lead immunotherapy (CT001, aka human FIST). The pre-clinical stage includes in vitro experiments to characterize Cura Therapeutics immunotherapies (CT001 variants) and in vivo experiments to determine Pk, Pd, MTD and efficacy studies in combination with immune checkpoint inhibitors in four mouse models of cancer (pancreatic cancer, colorectal cancer, breast cancer and melanoma).The goal is to build a pipeline that targets a broad range of solid malignancies that can be used as a standalone treatment or as combination therapies with CAR-T, Immune checkpoint inhibitors (ICI), or chemotherapy. The collaboration with Dr. Michel L. Tremblay lab will generate the data necessary to advance to IND-enabling studies.

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Faculty Supervisor:

Michel Tremblay

Student:

Partner:

Cura Therapeutics

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

McGill University

Program:

Elevate

Molecular Profiling of Survivin in Different Human Cancers

Survivin, a member of the inhibitors of the apoptosis protein family, is involved in multiple critical pathways of cancer cell growth and survival. Because of its selective expression in cancer cells but not in normal adult tissues, survivin is an attractive target for different cancer treatments. Immunovaccine Inc. (IMV) has developed a therapeutic cancer vaccine, DPX-Survivac, targeting survivn-rich cancer cells. The description should also indicate. Survivin over-expression was found in virtually all cancer types but not in normal tissues; however, it remains to be determined how its levels vary amongst different cancer types and within subtypes/stages of a given cancer. The goal of the proposed research is to identify cancer types/ subtypes, and stages with the highest levels of survivin expression. This will be achieved by a combination of microarray database mining and quantitative reverse transcription polymerase chain reaction (RT-qPCR)-based studies. The_results_of_this_research_will_help_IMV_and_others_to_select_patient cohorts that are best suited for survivin-targeted therapies.

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Faculty Supervisor:

Bill Pohajdak

Student:

Partner:

IMV Inc

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology

University:

Dalhousie University

Program:

Elevate

Plasticity of gene expression and chemical defences in an invasive weed

Garlic mustard (Alliaria petiolata) is an invasive plant in North America that produces glucosinolates and flavonoids as defensive chemicals. Production of these chemicals includes both plastic and genetic components, but the genes involved in these responses have not been characterized. We propose to use high-throughput sequencing and comparative genomic tools to characterize the complete set of RNA transcripts produced by the genome (transcriptome) of garlic mustard in order to identify candidate genes in the glucosinolate and flavonoid pathways, then sequence the most promising genes in 200 genotypes sampled across Europe North America to look for evidence of evolution during invasion. Understanding if and how this species evolves during invasion can help us understand more generally the role that evolution plays in the spread of invasive species.

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Faculty Supervisor:

Robert Colautti

Student:

Partner:

University of Arizona

Discipline:

Life Sciences

Sector:

Environmental Science and Technology; Forestry; Agriculture and Food

University:

Queen's University

Program:

Globalink Research Award

Filtering Process Optimization

Scrawlr is a platform for unconstrained, global interaction with all internet content and users. Scrawlr allows for user evaluation and unconstrained classification of any Scrawlr-hosted or non-Scrawlr content. For non-Scrawlr content, this evaluation and classification allowance will be first at the URL level but will subsequently be provided at the individual content component level.
The research conducted in this project will build an improved programmatic solution to the highly prohibitive database queries currently available when returning a precise result count for large and complex queries, a persistent issue that remains pervasive even with the use of advanced estimator usage tools.
This project will develop general and varying search and filtering optimization approaches for large tightly and loosely coupled datasets to be applied on a variety of technologies (rust/sql/php/lua/redis/redis search). Given current capability limitations, we must determine and optimize solutions for specific database and data storage performance issues at scale.

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Faculty Supervisor:

Abdelkader Ouda

Student:

Partner:

Scrawlr Development Inc.

Discipline:

Engineering

Sector:

Agriculture; Information and cultural industries; Professional, scientific and technical services

University:

The University of Western Ontario

Program:

Accelerate

Pumped hydroelectric vs utility-scale battery energy storage solutions for Alberta: A Life Cycle Sustainability Assessment approach

Renewable sources of electricity continue to increase in market share across all jurisdictions. New wind and solar energy projects in Alberta will be the main drivers to reach the province’s 2030 target to have 30% of its electricity derived from renewable sources. Alongside these projects the power generation companies like TransAlta Corporation will need to look at energy storage solutions to help these intermittent sources of electricity provide reliable and consistent power to the consumer. My research will compare the two most commercially available storage options of utility-scale battery storage and pumped hydroelectric storage. Analysis of these options will include comparison of environmental indicators, capital and operating costs, and social impacts such employment and community impacts. This research will assist in decision making for TransAlta in terms of which type of energy storage solution to pursue in the future.

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Faculty Supervisor:

Irene Herremans

Student:

Partner:

TransAlta Corporation

Discipline:

Business

Sector:

Utilities

University:

University of Calgary

Program:

Accelerate

Kisik clean energy solar photovoltaic power with Sayisi Dene First Nation

Sayisi Dene First Nation is a fly-in remote northern Manitoba community wanting to shift to clean energy. Kisik Clean Energy focuses for this project on shifting this diesel energy-dependent First Nation communities to solar energy integrating energy storage with lithium-ion batteries for assisting with microgrid technology. The Sun will soon deliver the Sayisi Dene community’s power, and the diesel generators can switch off to reduce the diesel used per year. All the feasibility and engineering work are to be done by Kisik staff with their contractors, with an Indigenous doctoral student from the University of Manitoba assisting with community engagement. Community engagement will help the community build their capacity and interest in solar energy. Community programs to ensure local well-trained staff receive the jobs and have back-up supports requires some training programs. This program will not be limited to the clean energy champions but extend to the community and school-aged children.

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Faculty Supervisor:

Shirley Thompson

Student:

Partner:

Kisik Marketing & Communication Ltd.

Discipline:

Business

Sector:

Utilities

University:

University of Manitoba

Program:

Accelerate

Designing and Prototyping an IoT System for Management and Predictive Maintenance of the Corn Fields at the Ottawa Smart Farm at AREA X.O

A Smart Farm is being setup at the Invest Ottawa AREA X.0 test facility premises with a financial contribution from the City of Ottawa. A local producer has planted corn on a demonstration field as well as on two further fields within the Ottawa smart farm (OSF). OSF enjoys the partnership of several local and global partners ranging from local producers to global agricultural technology and technology enterprises such as FarmersEdge, Trimble, and Microsoft. OSF wants to identify efficient platforms that enable local farmers to monitor the farming parameters of interest in order to optimize costs and support corn-farming decisions. Finally, as there is a flow of (eventually big) data that will be collected into the farming parameters, identified platforms must use a complete data management solution that drives the optimization of the farm costs and decisions.

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Faculty Supervisor:

Iluju Kiringa

Student:

Partner:

Invest Ottawa

Discipline:

Computer science

Sector:

Information and cultural industries; Management of companies and enterprises; Professional, scientific and technical services; Transportation and warehousing

University:

University of Ottawa

Program:

Accelerate

Predicting Hydrological Impacts on Remote Infrastructure Using Satellite Imagery and Machine Learning

After 17 months of closure due to flooding and washouts, Arctic Gateway Group (AGG) took over operation of Hudson Bay Railroad (HBR) in September 2018 and reopened 29 washouts in 54 days. Servicing northern First Nations communities and the Port of Churchill, one of the most important aspects of the HBR is safety. As a result, water monitoring and management remains a critical priority for the company. In particular, the section of rail line known as the ‘Herchimer’ remains an isolated and difficult portion of the track to monitor. The University of Winnipeg and Arctic Gateway Group endeavor to use drone and satellite technology to monitor water near rail lines in order to mitigate impacts on northern and remote infrastructure which is increasingly impacted by the melt of permafrost, a situation expected to increase with climate changes. The introduction of technology and processes that can mitigate impacts of water on northern and remote infrastructure stands to increase the economy in Canada’s northern and arctic regions by providing reliable infrastructure that has become impacted by global warming.

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Faculty Supervisor:

Joni Storie;Christopher Henry;Christopher D Storie

Student:

Partner:

Arctic Gateway

Discipline:

Earth science

Sector:

Transportation and warehousing

University:

University of Winnipeg

Program:

Accelerate

The Plundering Nation-State: Non-Persian Peoples, Environmental Exploitation, and the Rise of Modern Iran (1911-1978)

In my project, I aim to shed light on how the construction of modern nation state in Iran resulted in the environmental marginalization of the indigenous population across the country. The modern state in Iran, I contend, is a product of annexation and plundering of the resources and lands of indigenous populations and minority groups such as the Arabs, the Kurds, the Baluchis and so on. In fact, I aim to show how the Persian in Iran came to dominate the whole country, marginalized non-Persian communities and manipulate their natural resources in the course of twentieth century. Modernization policies and foreign-led developmental projects, especially in the context of the Cold War, have been of great importance for the Persian elites to marginalize the resources of the stateless population in Iran. in my project I aim to construct this history.

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Faculty Supervisor:

Ariel Salzmann

Student:

Partner:

University of Sussex

Discipline:

Sociology

Sector:

Indigenous Affairs; Natural Resources; Water

University:

Queen's University

Program:

Globalink Research Award

Kitigay: Indigenous food systems research with Brokenhead Ojibway Nation, Manitoba

This research documents the social impact of an Indigenous food systems development and education program called Kitigay. Kitigay means to plant in Ojibway to describe planting food but also ideas and education. This proposed participatory research supports farm and wild rice paddy design, implementation, training, and food product marketing in the First Nation of Brokenhead Ojibway Nation. This research explores how community-led Indigenous food systems education and projects can meet communities’ needs and priorities to foster Indigenous food sovereignty and self-determination. The study will also analyze the impact of the farm and capacity building on the Kitigay participants’ food security, educational outcomes and sustainable livelihoods. A baseline survey will initially provide a needs analysis to help put in place the required supports for students. Six-month and post-program longitudinal surveys will follow up this baseline to see the program’s medium and long-term impacts on participants. This study will be part of the national longitudinal study of at-risk youth in work-integrated social enterprises. Finally, the research will analyze farm and rice paddy designs and conduct field trials to ensure that the regenerative approach chosen is successful.

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Faculty Supervisor:

Shirley Thompson

Student:

Partner:

Brokenhead Ojibway Nation

Discipline:

Sociology

Sector:

Management of companies and enterprises

University:

University of Manitoba

Program:

Accelerate

Improvement in the quality of dissolving pulp

The dissolving pulp produced by Neucel Specialty Cellulose is a grade of pulp with high purity of alpha cellulose and used as the raw material to manufacture synthetic fibers, plastic materials, etc. The viscosity of pulp, one of the crucial factors, is undesirably decreased in the bleaching process, particularly in the hot alkali extraction stage, due to the so-called peeling reactions. Our research will minimize the peeling reactions with borol treatment, therefore will increase the pulp viscosity and upgrade the current product. The project will start with a lab study to investigate the borol treatment possibility and optimize treatment conditions. If positive results are confirmed, mill trials will follow to further optimize the condition and process design, monitor its effects on the pulp quality and overall production, and eventually integrate the borol treatment into the current mill operation system.

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Faculty Supervisor:

Yonghao Ni

Student:

Partner:

Discipline:

Engineering

Sector:

Manufacturing

University:

University of New Brunswick

Program:

Accelerate

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