Innovative Projects Realized

Explore thousands of successful projects resulting from collaboration between organizations and post-secondary talent.

13270 Completed Projects

1072
AB
2795
BC
430
MB
106
NF
348
SK
4184
ON
2671
QC
43
PE
209
NB
474
NS

Projects by Category

10%
Computer science
9%
Engineering
1%
Engineering - biomedical
4%
Engineering - chemical / biological

Reliability Study for Urban Transit Buses

The reliability of transit buses is essential for the cost-effective delivery of public transportation services. This research aims to improve the reliability of transit buses through optimized operational maintenance planning. We specifically wish to develop a mathematical optimization model that would help transit operators in deciding which bus components to repair during a maintenance intervention. The model will prescribe the repair decisions based on the current health condition of the various bus components, such as the engine and brakes, while simultaneously considering the bus operating costs along with the bus failure risk. The proposed model will be tested using real data provided by major Canadian transit operators and subsequently validated using a simulation program to be developed by the research team.

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Faculty Supervisor:

Viliam Makis

Student:

Abderrahmane Abbou

Partner:

WSP

Discipline:

Engineering - mechanical

Sector:

Management of companies and enterprises

University:

Program:

Accelerate

The Geography of Capacity–An Analysis of Individual, Organizational and Community Needs and Resources in Three Communities in Canada

This research presents a conceptual model of the geography of capacity and explores, through a small-scale study, the experiences of capacity across the nonprofit sector at the individual, organizational and community level in three different locales in Canada. By identifying the varied nonprofit capacity needs in different socio-economic and geographic locations, and by examining how organizations and communities understand these needs and strategize to identify resources, this research contributes to the discourse on the geography of nonprofits, infrastructure organizations and service provision. It challenges the dominant assumption that all agents within the nonprofit sector have equal access to resources, knowledge and ultimately the power needed to achieve outcomes. This study problematizes the capacity needs of the sector and corresponding infrastructure supports provided through the lens of socio-economic and geographic difference. TO BE CONT’D

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Faculty Supervisor:

Susan Phillips

Student:

Megan Conway

Partner:

Capacity Canada

Discipline:

Public administration

Sector:

Management of companies and enterprises

University:

Program:

Elevate

Evaluating the Impact of cannabis to reduce or manage illicit drug use in Vancouver, Canada

In North America, opioid and stimulant use are increasing at an alarming rate and contributing to unprecedented health harms, including an overdose epidemic that has been characterized by multiple levels of government as a public health crisis. Several recent studies have suggested potential uses of cannabis as a substitution or harm reduction strategy for opioid and stimulant use, pointing to the potential of cannabis to lead to reduced harms through the reduced use or outright substitution of potentially toxic illicit drugs. The pending legalization of non-medical cannabis in Canada might also have important implications on substitution and drug use patterns. The overarching goal of this study is to examine instrumental uses of cannabis to reduce or manage illicit drug use in the context of an overdose epidemic and its potential use as a therapeutic intervention. TO BE CONT’D

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Faculty Supervisor:

Ryan McNeil

Student:

Jenna Valleriani

Partner:

BC Compassion Club Society

Discipline:

Medicine

Sector:

Medical devices

University:

Program:

Elevate

Optimizing G protein-coupled receptor assays for autoimmune diagnostics

G protein-coupled receptors (GPCRs) are the largest family of membrane proteins and are involved in various disease including hypertension and airway diseases. With >30% of the prescription drugs targeting GPCRs, they have immense therapeutic importance. The detection of antibodies against GPCRs in these diseases has been a challenging task due to the lack of efficient detection assays, which are easy to use and economically available. The company Acudex has a long-term interest in the development of GPCR assays for autoimmune diseases. The proposed project is focused on the validation of the detection assays for two GPCRs, Angiotensin II type I receptor (AT1R) and Endothelin type A receptor (ETAR) and identification of the binding site(s) for antibodies on these GPCRs. Validation of the assay will be done by using a known antibody and serum samples from kidney transplanted patients. TO BE CONT’D

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Faculty Supervisor:

Peter Nickerson

Student:

Appalaraju Jaggupilli

Partner:

Acudex-Canada Inc

Discipline:

Medicine

Sector:

Medical devices

University:

Program:

Elevate

Effects of probiotic treatment on adulthood anxiety and obesity after exposure to Western diet

Scientific studies show that the connection between the gut and the brain affects obesity and anxiety development. Since exposure to stress increases these problems, the relationship
between stress and the gut-brain connection warrants investigation. In the proposed experiment, we will examine the impact of probiotic (beneficial gut bacteria) delivery on weight gain and anxiety in rats exposed to early-life-stress and a high fat and sugare diet. Through an industry collaboration, we are interested in helping Lallemand Health Solutions (Montreal,Canada) expand research on their probiotic, Probio’Stick®, by applying it to an animal model of stress, anxiety, and obesity. Ultimately, our research will aid in developing therapies to prev ent and treat human diseases related to life stress and unhealthy diet.

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Faculty Supervisor:

Tara Perrot

Student:

Elizabeth Myles

Partner:

Lallemand Health Solutions

Discipline:

Psychology

Sector:

Medical devices

University:

Program:

Accelerate

Exploring various approaches for investigating the mechanism of native diphtheriae toxin production by a C. diphtheriae strain: From –omics to nutritional to process approaches

Diphtheria is still a disease causing significant morbidity and mortality in people worldwide that did not received vaccination or suffer from incomplete immunization. The disease is due to a powerful toxin produced by the pathogenic bacterium Corynebacterium diphtheria. A good vaccine already exists but its production is rather complex and involves several steps: cultivation of the microorganism, extraction, concentration and inactivation of the toxin followed by extensive purification of the inactivated toxin (toxoid). Much research is still needed in order to increase the vaccine yield, this, to permit a significant reduction in production costs and to deliver a more reproducible and robust production process. Success will translate into a more affordable vaccine for people, especially people in underdeveloped countries. TO BE CONT’D

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Faculty Supervisor:

Denis Groleau

Student:

Mounia Akassou

Partner:

Sanofi Pasteur

Discipline:

Visual arts

Sector:

Pharmaceuticals

University:

Program:

Accelerate

Displacement-based Design of Hybrid Steel-timber Structures

Driven by heightened environmental awareness, the construction industry increasingly strives to utilize materials such as timber with a low-carbon footprint in their life cycle. High-strength mass-timber products, innovative ductile connections, and fast computer-numerically-controlled pre-fabrication, combined with changing legislation create better opportunities to also build tall timber structures. However, low ductility and limited tensile strength of timber are challenges for such buildings particularly in high seismic zones. By contrast, steel exhibits high ductility and tensile strength; the hybridization of steel and timber is an intriguing solution that offers new design opportunities. Current codes and standards, however, do not provide any design guidance for timber-steel hybrid structures. Displacement-based design (DBD) in which the seismic design problem is reduced to the evaluation of the allowed displacement and required strength that ensures all performance objectives are satisfied, has been identified as a promising approach. TO BE CONT’D

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Faculty Supervisor:

Thomas Tannert

Student:

Md Shahnewaz

Partner:

Dynamic Structures

Discipline:

Forestry

Sector:

Environmental industry

University:

Program:

Elevate

Assessment of Myocardial Perfusion Enhancement Associated with Current Treatments for Ischemic Heart Disease Using Positron Emission Tomography

Efficient pumping function of heart depends on receiving oxygen and nutrients through heart’s specific blood vessels called coronaries. In case of coronary stenosis (e.g. plaques formation on their inner walls), the heart muscle cannot function normally and may be permanently damaged. Three treatment strategies are broadly available that include medications, coronary stent placement and coronary bypass graft surgery. However, the efficacy of either treatment in restoring blood perfusion to the heart muscle is not clearly quantified. This knowledge gap prevents the physicians from systematically predicting the benefits and risks of each available treatment for every individual patient. The objective of the current study is to use positron emission tomography (PET) to measure coronary blood perfusion using a specific tracer that is rubidium-82 (Rb-82). TO BE CONT’D

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Faculty Supervisor:

Robert DeKemp

Student:

Ali Ahmadi

Partner:

Jubilant DraxImage Inc

Discipline:

Medicine

Sector:

Medical devices

University:

Program:

Elevate

Treating the Untreatable: Targeting Paediatric Brain Tumours with Multi-omics and Drug Discovery

Brain tumours, including ependymoma, are some of the most difficult cancers to treat. Although the past few years have seen many exciting advances in characterizing these brain tumours, there are few effective therapies available for patients, many of whom are children and young adults (and for whom long-term side effects can be extremely damaging). Until very recently, research in this area has been hampered by a complete lack of cell lines and animal models. Fortunately, the Taylor Lab at SickKids have successfully developed novel tumour culture methods to get these difficult cells to grow—producing the required model systems.
We now aim to use these new model systems to fully investigate the development of ependymoma disease and screen for compounds in the Structural Genomics Consortium (SGC) library that can be used to treat patients with this disease.TO BE CONT’D

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Faculty Supervisor:

Michael Taylor

Student:

ANTONY MICHEALRAJ KULANDAI MANUVEL

Partner:

Structural Genomics Consortium

Discipline:

Biology

Sector:

Medical devices

University:

Program:

Elevate

Advancement of bio-processing technology for ginseng polysaccharides: a model for value-added medicinal plant polysaccharides development

This proposed project focuses on American ginseng (AmG), a natural herb native to Canada that has been used as a traditional medicine for many generations. Southern Ontario has become the World’s largest producer of AmG with annual sales of over $400M at the farm gate. Polysaccharides (PS) are a major active component of AmG showing various biological activities including anti-carcinogenic, anti-aging, immunostimulatory and antioxidant effects. Despite of having such significant pharmacological activities, they have limited bioavailability due to their physicochemical properties including molecular size, heterogeneity, and solubility. Herein, advanced state-of-the-art technologies including nanosizing and encapsulation will be employed for enhancing penetration, absorption and controlled delivery. In addition, fluorescent dye labelling of PS will be developed to allow the tracking of PS. Pharmacology of these innovative health products will be studied to evaluate their safety and delivery efficacy. TO BE CONT’D

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Faculty Supervisor:

Paul Charpentier

Student:

Kazi Farida Akhter

Partner:

Western Phytoceutica Inc.

Discipline:

Engineering - chemical / biological

Sector:

Advanced manufacturing

University:

Program:

Elevate

Nanoparticle-encapsulated Cannabinoid and Temozolomide Combination Therapy for the Treatment of Glioblastoma Multiforme

Glioblastoma multiforme (GBM) (the deadliest form of brain cancer) is associated with poor survival rates (approximately 12-15 months from the time of diagnosis). This is due to the fact that most cases of GBM are resistant to current standards of care. As a result, novel effective treatment options are highly desirable. It has recently been shown that the combination of cannabinoids (such as THC or CBD) with the standard of care chemotherapy agent, temozolomide, demonstrates promise in the treatment of animal models of GBM. The main aim of this project is to design a novel nanoparticle that can deliver a combination of cannabinoids and chemotherapy to GBM tumours.
The proposed project combines 13 years of nanoparticle and drug combination research in the Allen Lab, with Avicanna Inc., a Toronto-based medical cannabis company. TO BE CONT’D

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Faculty Supervisor:

Christine Allen

Student:

James Evans

Partner:

Avicanna Inc

Discipline:

Pharmacy / Pharmacology

Sector:

Pharmaceuticals

University:

Program:

Elevate

Molecular Characteristics of Cellulose and Cellulose Derivatives

Cellulose is a commercially important biopolymer. Due to its abundance, biocompatibility and renewability it has shown important commercial applications in food, pharmaceuticals, biomedical. Depending on the origin and the processing methods used, the resulting fiber dimensions, structure, crystallinity and molecular weight (MW) can vary over a broad range. MW is one of the most important parameters in polymer characterization as many of its properties depend on it. Gel permeation chromatography (GPC) has been the technique of choice for determining these properties. However, this method has limitations and requires optimization. Its accuracy is dependent on complete dissolution of the sample. Cellulose is insoluble in most solvents due to its structure and strong hydrogen bonding network. Either derivatization or special solvent systems have been used for solubilization. Derivatization changes the chemical nature and there is no consensus on a definitive solvent system for cellulose. TO BE CONT’D

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Faculty Supervisor:

Wankei Wan

Student:

Solmaz Karamdoust

Partner:

PolyAnalytik Inc

Discipline:

Chemistry

Sector:

Natural resources

University:

Program:

Elevate

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