Reduced number of insulin producing ?-cells in pancreas due to increased ?-cell death is a key defect in diabetes that eventually leads to elevated blood glucose levels and life-time treatment with glucose lowering drugs or daily insulin injections. Thus, finding therapeutic approaches to prevent the decrease in the number of insulin producing ?-cells in diabetic […]

Recently, positron emission tomography (PET) and magnetic resonance imaging (MRI) have been successfully combined into a single system that can collect clinical PET/MRI data simultaneously (Siemens Biograph mMR). With PET, a wide variety of tracers have been developed that can measure energy usage and concentrations of disease-specific features in the brain. In collaboration with Siemens […]

Patients with cervical spine degeneration are difficult to diagnose and treat. Some patients will not benefit from surgical intervention while others require immediate surgical management to avoid permanent neurological deficits. Distinguishing between these patient groups is very difficult, and not effectively done with current protocols. Medical imaging is part of the current diagnostic protocol for […]

Visual analytics (VA) potentially has a great range of applications within healthcare. CAREX and Engage Data will investigate, with the intern, the uses of VA for data analysis and visualization to support real-world carcinogen-related explorations related to the use of the eRISK Online web-based tool developed by CAREX. Engage Data is specifically interested in understanding […]

Significant scientific knowledge gaps remain with respect to nuclear power production and impacts on the environment and the community. Four specific research areas for interns have been identified to help resolve some of the issues or gaps in knowledge. The specific areas of research include: (A) determining appropriate thresholds for animal population-level effects, (B) assessing […]

As a novel solution for the treatment of common paediatric neurological diseases, this project aligns with goals of the Toronto General and Western Hospital Foundation of promoting surgical innovation and improving patient care. Philips Healthcare Canada has a proven track record of research and development in the healthcare industry and is able to provide research […]

For people with lower limb amputations, the interface between the amputated limb and a prosthetic socket is very important. Suspension, or how the socket is held on the limb, is one factor that affects a person’s ability to walk efficiently and safely, movement confidence, limb health, and quality of life. This project will assess, evaluate, […]

Climate change is a fairly new phenomenon and its impact on health is poorly understood. Extreme weather events are becoming increasingly common, but the effect on vulnerable populations such as women and children is largely unknown. One particular problem that limits research on the impacts of extreme weather on health is the lack of indicators […]

Objective. The primary objective of this cohort study is to determine if use of opioids increases the risk of ovarian cancer recurrence and metastasis. The specific objectives are to determine whether: 1) use of IMM opioids during surgery increases the risk of cancer recurrence or metastasis when compared to NIMM opioid use, among patients undergoing […]

Multiple sclerosis (MS) is a chronic degenerative disease in which central nervous system demyelination and white matter inflammation leads to axonal injury and neurological deficit. Canada has one of the highest rates of MS incidence in the world; studying the pathogenesis of MS is of the utmost importance. MS pathology results from myelin-directed autoimmune attack […]

The research project involves investigating the structure and function of DISC1 subdomains. As DISC1 is a large protein with multiple functions, breaking it down into its subdomains will facilitate our understanding of its biology. The biochemical and biophysical properties of subdomains will be characterized. This 12-week project will allow the student to learn how to […]

Nlrx1, belongs to NLR family of intracellular sensors that regulate mayor cellular pathway including cell death and inflammation. Previous research implicated Nlrx1 in regulation of autophagy and reactive oxygen species production during viral infection. In addition most recent publication implicated Nlrx1 in regulation of the cell death in fibroblasts cultures. Our preliminary data show that […]