3d density estimation using normalizing flows and its application to 3d reconstruction in cryo-EM

Generative models enable the researchers to address multiple problems spanning from noise removal to generating novel samples with properties of the domain. Generative models are commonly studied for images and in this project the idea will be expanded to 3D structures or volumes. Single-particle cryo-electron microscopy (cryo-EM) is a technique to estimate accurate 3D structures […]

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CardiAI Point-of-Care Device for High-Caliber and Rapid Diagnosis of Biomarkers from Blood of Patients for Early Heart Failure Detection

The aim of this research and development project is to design and develop a bedside point-of-care device to be equipped with the CardiAI’s machine learning technology for heart failure management. Our POC system will include disposable cardiac biomarker strips and an electronic reader. Once implemented, it will be connected to the AI platform that will […]

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Forecasting Profitability of Real Estate Assets using Machine Learning

This research project aims at applying machine learning over the existing financial forecasting methods currently employed in the commercial real estate industry. Businesses are actively collecting more data than what can be analyzed effectively using the standard spreadsheet models which have become industry standard over the past few decades. Machine learning algorithms are known to […]

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Hoy Creek Shared Equity Home Ownership Project: Models, Applicability, and Administration

The Hoy Creek Shared Equity Home Ownership Project aims to provide a site-specific example of how a shared equity home ownership project can succeed in Canada. As few Canadian examples exist of scalable affordable home ownership models, more research is required to identify options for implementation and strategies for long-term administration. This research project aims […]

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Mobilizing Ulukhaktok Traditional Knowledge of the Dolphin and Union Caribou Herd

The Dolphin and Union caribou herd is integral to Inuit culture, subsistence and identity. Preliminary local and scientific knowledge both indicate that this caribou herd is declining and in poorer health than before. We need to bring everyone together and use everything we know about Dolphin and Union caribou, the environment and the other animals […]

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Safe and Smooth Path Planning for Autonomous Robot Navigation

Clearpath Robotics has developed an accurate GPS navigation system that enables autonomous robots to move in outdoor environments. However, to move toward a target location and avoid obstacles along the path, a path planner is required. The objective of this project is to develop, tune and modify an efficient path planner for the robot in […]

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Clinical Implementation of Contralateral Inhibition OAE Testing

The proposed research project seeks to develop protocols that will enable one to measure the functionality of the auditory brainstem in a way that is clinically viable and time efficient. This project aims to minimize the time necessary to conduct an inclusive otoacoustic emissions (OAE) test using contralateral acoustic stimulation. By setting threshold signal to […]

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Advanced Characterization of Zirconium Hydrides in Zr-2.5Nb Pressure Tube in CANDU Reactors

In the operation of CANDU reactors, the Zr-2.5Nb pressure tubes holding the cooling water and fuel bundles are susceptible to hydride cracking-induced crack initiation mechanisms, known as delayed hydride cracking and overload crack initiation. For structural integrity evaluation of CANDU pressure tubes, of fracture toughness and hydride crack initiation models were developed. However, the hydride […]

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Enabling next generation cardiac therapeutics with genetic engineering and novel in vivo models for cardiomyocyte transplantation

The development of cellular therapeutics is acutely dependent on the ability to evaluate the functional characteristics of the cells in predictive animal models. This forms the basis of key pre-clinical data packages that are key for regulatory submissions preceding human clinical trials. The development of appropriate model systems, the execution of the surgical techniques to […]

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Validation of Novel, Tumor Microenvironment-based Targets for Biological Therapeutics

ImmunoBiochem is developing novel anti-cancer therapeutics to address unmet need in intractable solid tumors. Because solid tumors are highly heterogeneous and evasive, recognizing cancerous cells, while avoiding damage to normal tissue, is a challenge. As a result, many targeted therapies quickly come up against resistance, resulting in patient relapses. ImmunoBiochem is solving the issue of […]

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Human Body Capture and Prediction from Rehearsed Live Performances

We address the problem of 3D human body motion capture and prediction to be used in the context of a live music concert performances. The difficulty of capturing the motion of a performer in this context comes from the harsh environment in which it takes place that includes strong and varying lighting, smoke generators, and […]

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