A new paradigm for the discovery of anti-cancer drugs based on tumour RNA disruption

While chemotherapy drugs are effective in combating tumour growth in cancer patients, many such drugs permit the development of drug-resistant tumours and progression of the disease. We have observed that several chemotherapy agents induce the degradation of tumour cell ribonucleic acid (RNA) in the laboratory and in cancer patients. We have further shown that this […]

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Experimental Study on Vectorbloc Connection Used in Modular Construction

Modular construction has been gaining its popularity and momentum because it is a cheaper and faster way to build buildings and other structures. Vectorbloc Corp., located in Toronto has developed the concept of steel tubular modular construction using hollow structural steel (HSS) members. This modular construction will use various connectors and assemblies. The primary connector […]

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Dopamine Receptor Imaging in Dementia Using Hybrid PET/MRI

Although life expectancy is increasingly associated with the treatment of heart disease and cancer, there has been virtually no improvement in life expectancy for patients with dementia. Dementia has a devastating impact to the patient, family members and society because patients become dependent on family caregivers, who are then less productive in other aspects of […]

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Prospecting mine and mineralogical sites for energy recovery and bioproducts

The mining industry is looking for technologies that improve sustainability through reducing environmental and energy burdens. In line with this, a program was created between Sudbury Integrated Nickel Operations, a Glencore Company and Laurentian University to prospect for opportunities for making better use of existing non-mineral resources. Interns on the Mitacs program will bioprosepect mine […]

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Investigation and optimization of Avalon Alliance bio-mineral composite products and pre-design of the manufacturing process

This UBC-Vancouver research will contribute to the optimization of novel composite bio-mineral products for sustainable agriculture, pollution remediation and other environmental applications, with special emphasis on equipment pilot testing and manufacturing process pre-design, as well as the testing of the product as chicken/fish feed. The core fertilizer products synergistically combine rock dusts, clays, seawater elements, […]

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Investigation of biomarkers of response to treatment with marizomib in GBM patients

Development of cancer is mainly due to uncontrolled cell growth and the proteasome is a cellular component that regulates this process. Resistance to chemotherapy is the main reason for cancer treatment failure, and therefore,there is a need for development of new and potent drugs. Recent studies have shown that proteasome inhibitors effectively inhibit growth of […]

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Validation of neurodegeneration screen hits in zebrafish: functional analysis of drug effects on neural activity

The OCE-CQDM Life Sciences R&D Challenge program is a groundbreaking collaboration between researchers at St.Michael’s Hospital (SMH) and Treventis Corporation (both in Toronto), as well as the University of Montreal (Dr. Drapeau, an expert in zebrafish models of disease). The zebrafish is a robust model for translational research because of our understanding of zebrafish biology […]

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Learning from our Kogums (Grandmothers): Integrating Participatory Video as a Tool to Share Knowledge through OPCN’s Ithinto Mechisowin Program

Hydroelectric dams are hallmarks of colonization in Canada, as they destroy food sources, homeland, habitation, and natural resources of Indigenous peoples. O-Pipon-Na-Piwin Cree Nation (OPCN), an Indigenous community in northern Manitoba, Canada, was flooded and forced to relocate from ancestral lands to a nearby settlement under such circumstances. Regaining strength from their inherent cultural values […]

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Switching frequency optimization and advanced current control techniques for an electric vehicle traction drive

The performance of an electric vehicle traction drive, comprised of an electronic power converter feeding power to an electric motor, is defined by its control stages and different system parameters- such as switching frequency of the semiconductor devices of the converter. The proposed internship aims to determine changes in conventional control strategies and selection of […]

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Injection molded bioprinter cartridges

Patients who suffer from severe burns require immediate wound closure to ensure survival and facilitate healing. The current gold standard in surgical practice is the use of split-surface autographs, allographs, or skin substitutes, but limitation range from the lack of layered tissue organization, the potential for immunological rejection, and the need for high quantities of […]

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Development of Novel Microparticle and Nanoparticle-Based Controlled Release Formulations for Agriculture

Increasing the productivity of agricultural fields is essential to secure our existing food supplies and provide for the growing world population. In this context, pesticides and fertilizers play an essential role in both increasing crop yields, as well as enhancing crop defenses against environmental stresses such as drought, pests, or diseases. However, the application of […]

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