Development of cancer is mainly due to uncontrolled cell growth and the proteasome is a cellular component that regulates this process. Resistance to chemotherapy is the main reason for cancer treatment failure, and therefore,there is a need for development of new and potent drugs. Recent studies have shown that proteasome inhibitors effectively inhibit growth of […]

The goal of this project is to develop the first ever high definition integrated water circulation and water quality model for the Toronto Waterfront. As one of the most urbanized freshwater ecosystems with complex geometries and physical processes, Toronto Waterfront is in an urgent need for modern scientific tools that can support effective environmental management […]

Patients who suffer from severe burns require immediate wound closure to ensure survival and facilitate healing. The current gold standard in surgical practice is the use of split-surface autographs, allographs, or skin substitutes, but limitation range from the lack of layered tissue organization, the potential for immunological rejection, and the need for high quantities of […]

Increasing the productivity of agricultural fields is essential to secure our existing food supplies and provide for the growing world population. In this context, pesticides and fertilizers play an essential role in both increasing crop yields, as well as enhancing crop defenses against environmental stresses such as drought, pests, or diseases. However, the application of […]

Waba Dam is a zoned earth fill structure that was constructed on a deep soft, sensitive marine clay layer. This marine clay layer is characterized by its low shear strength and a large void ratio. During the last 32 years, the dam and its foundation has settled over 1.5 m (5 ft). Piezometric readings indicated […]

IL Canada would like to increase their revenue streams through inititating market-based approaches. The organization has struggled to identify appropriate social enterprise opportunities that can be replicated across the country. Examples of social enterprise opportunites for a NFP include: adding fee-for-service consulting; starting a new for-profit company that donates all profits to the organization; and […]

The Grand River Water Management Plan is a collaborative initiative endorsed by more than 30 partner organizations, outlining best value solutions to current watershed challenges. The Plan identifies knowledge gaps, including the need to better understand the impacts of urban stormwater on the Grand River. The proposed research project draws on existing water quality and […]

The GeneSight (GS) Psychotropic Test (AssureRx Health, Inc.) measures individual variations in drug-related genes and recommends optimal drug choices for individual patients. A clinical study will be conducted to validate novel gene markers of antipsychotic-induced weight gain for use in an enhanced version of GS. Sarah Groleau will be responsible for genotyping DNA from 600 […]

Geomechanica Inc. develops simulation software (Irazu) for rock engineering applications. This numerical software has been used in several peer-reviewed research publications in the rock mechanics field. A key challenge in the numerical modelling of rock masses is the selection of appropriate input parameters. The objective of this work is to develop a solution to streamline […]

The current wellbeing crisis in Canada is magnified in rural areas. Also, rural economies are negatively affected by lack of suitable youth lifeskill training. Rural communities lack financial capital to address these issues on their own. 4-H has been building rural youth skill for over 100 years, offering a variety of options, including physical activities […]

Groundwater contamination by hydrocarbon fuels such as gasoline and diesel fuel is a serious threat to the environment and human health. Sources of this contamination include leaking underground storage tanks, pipleline breaks, tanker truck accidents and train derailments. There is a need for improved understanding of the mobility of hydrocarbon fuels in the subsurface to […]

Contemporary machine learning has been very successfully applied to processing static images and words in consumer applications, resulting in billions of dollars in recent acquisitions of machine learning companies by Microsoft, Amazon, Facebook, and Google. However, applications to dynamic information (e.g. movies, controlling robotics) has been less well-developed. In this project, will develop and apply […]