Several fish species produce species-specific sounds that can be identified in the wild using Passive Acoustic Monitoring (PAM) (i.e. dataloggers configured with underwater microphones). Our project will use existing and new PAM recordings to monitor the distribution of several fish species in the western Canadian Arctic, with particular focus on a keystone Arctic species, the […]

To perform a complete molecular analysis of muscle invasive bladder cancer (MIBC) before and after pre-operative chemotherapy to find changes responsible for resistance to treatment. Analysis will include a combination of DNA sequencing, RNA expression analysis and quantification of protein. Together this information will reveal the molecular landscape for these tumors. We will use these […]

Perfusion imaging with a CT scanner provides important information about blood flow and, in acute ischemic stroke, highlights regions of brain infarct, where tissue has died because of a lack of blood flow. This infarct region continues to grow over time until blood flow is restored. Being able to predict the rate of infarct growth […]

Most economically important traits associated with lactation and reproduction in pigs are either less heritable, sex-limited, expressed later in life, or difficult to measure on a routine basis. Genomic predictions using single step best linear unbiased prediction (SSBLUP) methodologies, which utilizes information on phenotypes, pedigree and markers from genotyped and non-genotyped animals simultaneously, is an […]

The business of Molecular You Inc. (MYCO) is to provide a comprehensive Personalized Medicine bioinformatic and health monitoring program for disease prevention, detection, and treatment that integrates “omics“ data with behavioral, and environmental data for customers and their caregivers. This project is part of a larger initiative that “seeks to innovate in the way people […]

Hypoxic cells comprise most aggressive and therapy resistant population in the tumors therefore targeting proteins that are essential for hypoxia survival is an effective novel anti-cancer treatment. We have an ability to generate highly specific humanized synthetic antibodies against target of choice. We will generate antibodies against proteins that promote hypoxia survival, test their effect […]

Signaling through the Eph family of cell surface receptors is crucial for embryonic development and the maintenance of adult tissues. Given the central role of the 14 Eph receptors in controlling cell fate, it is not surprising that they also play a central role in oncogenesis and other pathological conditions. However, the signaling mechanisms of […]

The company Odyssée Biotech specializes in the production of natural flavors and fragrances using innovative enzyme technologies. Using natural enzymes allows the enterprise to produce highly pure ingredients in mild conditions with a natural label. This green approach also makes this technology highly competitive and environmentally sustainable relative to other production methodologies employed in the […]

Iron-overload disorders, such as hereditary hemochromatosis (HH) and beta-thalassemia, develops when the body absorbs excessive iron over years. They are quite common with a prevalence of 1/200 in population of northern-European ancestry and 1/500 worldwide respectively. Without treatment, iron-overload can lead to diabetes, heart disease or cirrhosis. Main treatment for HH is phlebotomy and patients […]

Greenhouse industry is an important agricultural sector in Canada. Approximately half of the Canadian vegetables is produced in commercial greenhouses. Ontario greenhouse industry contributes to 40% of greenhouse production in Canada. As one of the most important greenhouse crops, tomato production is threatened by canker disease leading to significant loss for growers. Tomato canker disease […]

A new revolution in life science research is ongoing since the discovery of the CRISPR/Cas system. With this technology is now possible to specifically and efficiently manipulate the genome of cultured cells, embryos and animals. The technology has many applications in agriculture including the dairy genetic industry to generate the next generation of elite animals […]

Thick-billed murres from breeding colonies throughout the North Atlantic, and common murres from colonies throughout the northwest Atlantic winter off Newfoundland, Labrador and Greenland where they are the object of an annual hunt. The winter murre or ‘turr’ hunt is an important part of the culture of coastal communities, and is protected under Canadian legislation. […]