Physiological assessment of cochlear and auditory nerve integrity in children suspected of auditory processing disorder

The American Speech-Language-Hearing Association (ASHA) recommends to include electrophysiological measures in their auditory processing disorder (APD) assessment battery. But few audiologist include electrophysiological assessment due to lack of evidence. There is strong evidence of auditory brainstem abnormality in these children. However, very less is understood about stimulus processing within the cochlea, auditory brainstem coding in […]

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Developing a Lipid-Based System for Co-delivery of a Vaccine and Adjuvants

University of British Columbia and Amgen British Columbia (ABC) will collaborate to develop a safe and efficient lipid-based vaccine delivery system that can be used in laboratory animals to enhance the production of specific antibodies against difficult targets. These antibodies can be further screened and characterized for treating various diseases in humans.

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Progress towards a new technique for aptamer sensor development and analysis

Aptamer based sensor development can be challenging. While aptamer selection has provided a very useful method of producing molecules that selectively bind compounds of interest to the fields of public health, regulatory control and legal enforcement, the steps required for incorporation of aptamers into sensors are not trivial. Specifically, gaging how well aptamers bind their […]

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Using PET/MRI to improve current pre-clinical biomarkers in cancer

Treatments that involve activating a patient’s own immune system, immunotherapies, are becoming important cancer therapies. Unfortunately, doctors don’t always know the best way to combine these therapies to best treat patients and the current tools they have to evaluate treatment success don’t work well for immunotherapies. Molecular imaging, particularly magnetic resonance imaging (MRI) or positron […]

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Somatostatin signalling and diabetes

The prevalence of diabetes is growing rapidly and currently, over 60 million people worldwide use insulin treatment to manage their diabetes. However, insulin treatment can result in hypoglycemia or low blood sugar levels. To date only retroactive treatments are available to treat hypoglycemia, which affects an individual’s quality of life and increases the likelihood of […]

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Effects of dietary glutathione precursors on cellular redox and mitochondrial efficiency in adults consuming a defined hypocaloric diet (Optifast-900; Nestlé Canada)

The aim of the proposed research is to investigate the cellular mechanistic effects of supplementation with a hypocaloric meal replacement product (Optifast-900; Nestlé Canada) containing cysteine and glycine, which are amino acid precursors of the antioxidant glutathione. Impaired cellular glutathione redox normally occurs with aging and metabolic disorders, however, this study will focus on a […]

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The effects of X-Act Compression garments technology on muscle fatigue, active and passive joint torque and performance

There are many compression garment products on the market claiming to improve some aspect of performance, however their claims are not validated with empirical data. In fact, current literature regarding the benefits of compression garments on cardiovascular and biomechanical performance is controversial; with many results suggesting non-significant or even negative effects provided by the compression […]

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Characterization of Naturally-Occurring Neuropathic Pain in Dogs

Clinical experience demonstrates that canine patients commonly suffer from neuropathic pain and little is known to address this issue. Our study aims to investigate different tools for the diagnosis and treatment of neuropathic pain. Forty dogs with naturally-occurring neuropathic pain will be included in a prospective, randomized, masked clinical trial using appropriate inclusion and exclusion […]

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Novel Cell-surface Engineering Methods to Increase Immune-tolerance of Allogenic Cell Transplantation

Blood transfusion is required for surgery, for the treatment of traumatic accidents and for patients with disorders that require lifelong transfusion therapy. However, when patients receive “mismatched” blood transfusion, their immune system will attack and destroy red blood cells with surface sugars and proteins that differ from their own. This results in massive immune responses […]

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An Integrated Mobile Communication Environment for Healthcare Professionals and Patients: Analysis, Prediction and Recommendation

Think Tank Innovations Ltd is a company active in the healthcare domain. The company is interested in expanding their current working system Sharesmart application by benefiting from advanced technology to develop an integrated environment for healthcare solutions in order to better service a wider community locally and globally. Students to be involved in this project […]

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