Glioblastoma multiforme (GBM), also known as glioblastoma and grade IV astrocytoma, is the most common and most aggressive cancer that begins within the brain. There is no clear way to prevent the disease. Typically treatment involves surgery after which chemotherapy and radiation therapy is used. The medication Temozolomide (TMZ) is frequently used as part of […]

Every job at Ford Motor Company should have an associated document describing the physical demands (i.e., lifting, climbing, pushing, etc.) required in that job. This information is important to select job candidates with the right blend of capabilities to be able to safely meet these demands. Perhaps more importantly, this information also provides a benchmark […]

Using growth media available from Stemcell technologies, along with our own tools and techniques, we can isolate and grow intestinal stem cells from mice or human patient donors into enteroid cultures. Enteroids are 3D cell cultures that replicate many of the structures and types of cells found in the intestinal lining. We propose to work […]

Prior research has shown that rolling muscles can increase flexibility without performance decreases. These studies have used a variety of rolling pressures (intensities). It is not known whether higher or lower rolling pressures are better for improving flexibility. Thus one of the studies will examine different pressures of rolling on flexibility and muscle performance. On […]

The research project will develop key algorithms that enable pulse oximetry, on a smartphone, to be used effectively as a device for monitoring the function of heart and respiratory system at home. LGTmedical has developed a pulse oximeter that utilizes inexpensive clinical sensors driven by software running on a smartphone, sending the driving signals through […]

In human viral diseases, misbehaviour of the cellular machinery utilizing ubiquitin is frequently observed. Ubiquitin is a small protein that attaches to target proteins in human cells and signals for their destruction. Human deubiquitinases are enzymes that remove ubiquitin to keep protein levels in balance. Viral pathogens have evolved proteins that mimic human deubiquitinases to […]

With the increasing prevalence of mobile devices, it is unsurprising that they are also being adapted for use as tools for learning and perfecting complex procedures. One of these uses is training health care providers through simulated medical procedures. Two important points should be considered when designing simulated systems to assess the efficacy and efficiency […]

“Seismocardiogram (SCG) is a signal that is captured by placing an accelerometer on the human chest. This signal captures very important timing information such as opening and closing of the heart valves. In addition to these timing information, the non-invasive nature of this signal makes it an attractive solution for remote monitoring of patients with […]

The goal of this project is to provide evidence of validity for two newly developed measures of quality of life; one for hidradenitis suppurativa (HS) and one for acne. Both HS and acne negatively impact quality of life; however, to date, there are no disease-specific, patient-centered quality of life measures. The results of this project […]

The promotion and maintenance of men’s pelvic floor health is a growing concern as pelvic disorders affect a substantial number of men and their prevalence is expected to increase as a result of Canada’s aging population. Pelvic floor disorders go beyond their physical consequences as they can negatively impact men’s psychological, sexual, and social quality […]

Diagnosing and managing concussions have become an increasing priority in sports medicine. The King-Devick test is a screening assessment of neurological functioning detecting impaired eye movements and saccades. During the 2016 Canadian Football League (CFL) season, all players will undergo pre-season (baseline) and post-injury testing with the King-Devick test in addition to the CFL’s standardized […]

Inter-tissue adhesions cause significant complications following veterinary surgery of domesticated animals. Fucoidans are natural, negatively charged, carbohydrate polymers (polysaccharides) from seaweeds that have been successfully developed and commercialized for reducing such adhesions, thereby improving surgical outcomes. Currently, the inherent variability in the molecular size and composition of native fucoidans extracted from seaweed presents a significant […]