Bacterial resistance to aminoglycoside antibiotics is a major public health problem. The WHO (World Health organization) has highlighted the urgent need to find new treatments to fight multidrug resistance MDR bacteria, as actual drugs are less effective or inactive. This research project aims to develop new chemical compounds to restore bacterial sensitivity to antibiotics currently […]

Serial electron diffraction (serial-ED) crystallography is an emerging structural biology method whereby data are collected from protein nanocrystals using a sub-micron-sized electron beam. The method is set to lead the future of nanocrystallography, given its cost-effectiveness and the small amount of sample required. Combining the expertise of the Colletier and Miller teams, the project will […]

Cholinergic compounds can act as both pharmaceuticals and bioactive compounds in functional foods. Alpha-Glycerylphosphoryl choline (alpha-GPC) is a known cholinergic compound that is used in Korea as a prescription pharmaceutical for treatment of Alzheimer’s disease. However, development as a functional food and related researches in Korea is limited. Recently, the team led by Dr. Martin […]

Antimicrobial resistance (AMR) occurs when antibiotic drugs and products stops working, making it difficult to treat infections and diseases which could lead to further health complications and death. Therefore, development of antibiotic products is needed to control the increasing cases of AMR. Medicinal plants are a great source of natural antibiotic compounds to make antibiotic […]

Depuis le début de la crise du Covid, Thales Digital Solutions tente d’adapater une partie de ses algorithmes d’optimisation et de prédiction au domaine médical. Il y aura 2 trames de recherches principales : – les hopitaux et la gestion des salles d’opération – les pharmacies et la précision/gestion des commandes L’objectif principal de la […]

The project mainly focuses on the cellular behaviour and ways to predict human gene interactions. Using a method called Proteinfragment Complementation Assays, we are able to compute the biochemical networks in living cells. The results of this project will provide a novel and highly efficient way to establish hypotheses about the organization of cellular regulatory […]

Amaryllidaceae alkaloids (AAs) are a group of specialized metabolites found predominantly in the Amaryllidaceae plant family. Approximately 650 naturally occurring AAs have been identified, many of which possess a variety of potent biological and pharmacological properties. In contrast to the large body of knowledge on the pharmacological and phytochemical aspects of AAs, their molecular and […]

Cancer is a disease that involves the uncontrolled division of cells in the body. Cancer begins when the cells disobey normal cell division and cell death processes and is a disease that affects millions of people worldwide. There is a type of cancer that is caused by a mutation in the epidermal growth factor receptor […]

Lipid nanoparticles (LNPs) are a form of new dosage form for delivering drugs, including anticancer agents and vaccines. A highly controlled production system is needed to produce high quality LNPs, and the existing production systems suffer from a few drawbacks, such as lack of variable control and automated functions. Dionamix will employ their technologies and […]

Cancer cells can travel to distant sites through the lymphatic system; this system is similar to a network of pipes within the body that carries fluids and cells to all organs. The metastatic spread of cancer cells through this network is one of the reasons why this disease is so difficult to stop. We are […]

Le projet consiste à synthétiser un nouveau système d’encapsulation d’ARN messager. L’objectif est donc de développer un matériau polymère plus stable et moins coûteux pour son utilisation dans des applications comme les vaccins à ARN messager. Grâce à ce nouveau système nous espérerons rendre les traitements plus efficace lors de leur insertion dans le corps […]

Le projet à pour but d’obtenir une surface avec des propriétés qui peuvent changer grâce à une stimulation. Dans notre cas une stimulation à une longueur d’onde précise. Dans un premier temps je dois synthétiser un polymère qui va permettre de changer la nature de la surface de silice. Ce processus ce fait en plusieurs […]