Oral cancer is one of the most aggressive forms of cancer, and the incidence of new cases and mortality is rising worldwide. Currently, oral cancer is treated with chemotherapy agents alone or in combination with radiotherapy or surgery. Chemotherapeutic approaches made the patients suffer from severe side effects and drug resistance. Henceforward, the current focus […]

Our project is to discover a more effective way to treat oral cancer that includes Eugenol and Carnosol and its derivatives that are effective in treating different types of cancer and also examining their beneficial (preventive and therapeutic) effects. The specific objectives: 1) To study the antimicrobial and anti-inflammatory effects of these two compounds as […]

Myocardial infarction is among the most prominent causes of death worldwide. Following cardiac injury, changes in the composition of the extracellular matrix trigger inflammatory and fibrotic responses. Particularly, left ventricular remodeling and cardiac fibrosis are characterized by pathological glycosaminoglycan (GAG) production and ECM rearrangement, which contribute to cardiomyocyte death and subsequent heart failure. Additionally, chondroitin […]

Gene therapy has risen as one of the more promising treatment options for disorders of the central nervous system (CNS). Using modified viruses to deliver genetic material has shown success however has several disadvantages including increased safety risks. Using a non-viral vector system has the potential to overcome many of the challenges that arise with […]

Les macrophages sont des cellules immunitaires essentielles pour la défense de l’organisme face à une blessure ou une infection. Cependant, leur recrutement dérégulé peut devenir problématique dans certains contextes pathologiques. Ainsi, dans la grande majorité des cancers solides, l’infiltration massive des macrophages favorise la progression de la maladie, et il est devenu crucial de déchiffrer […]

Three decades ago, science saw a major revolution in the nanomedicine field. The invention changed the dynamics of drug delivery and ever since, numerous studies have been done to help in delivering drugs with the aid of nanomedicines. Dendrimers are new generation of vectors used in skin drug delivery mostly because of their small size, […]

La stagiaire développera des méthodes d’analyses de protéines liées à l’inflammation pour la détection de la réponse immunitaire suivant une infection à la COVID. Elle procédera à l’analyse d’échantillon, la production de rapports et possiblement à la rédaction d’article. Elle utilisera des techniques de résonance des plasmons de surface.

Il s’agira de rendre compte de l’expérience particulière de la communauté gaie à Montréal prennant la PrEP (de manière continue ou intermittente), de comprendre les facteurs interdisciplinaires jouant un rôle dans la démocratisation du traitement prophylactique. Aussi, j’aimerais procéder à une analyse comparative avec la Suisse afin d’offrir une entraide internationale dans cette démocratisation. Les […]

Having an efficient and scalable manufacturing production process of Adeno-Associated Virus (AAV) vectors remains one of the most challenging problems in the industry for meeting the high demand of AAV for clinical application in gene therapy. The current production process of AAV relies on the co-transfection of three plasmids containing the main virus structural and […]

The goal of this project is to train and test a machine learning algorithm to detect pharmaceutical contaminants in water. Surface nanodroplets will be generated for several key compounds. These, will be used as independent extraction medium with varying contaminant concentration. The large number of droplets will enable collection of a high quality training data […]

Cancer is a devastating disease known to be treated with chemicals causing severe side effects in the advanced stages of the disease. Among these chemicals are a group of antibiotics, called anthracyclines, used to treat a variety of cancers, including breast cancer (BC). Doxorubicin, one of the preferred anthracyclines used in BC treatment, is particularly […]

To prevent diseases such as coronavirus disease 2019 (COVID-19) and Ebola virus disease vaccines are the most effective tool. For this, the promising viral vector recombinant vesicular stomatitis virus (rVSV) is applied as production platform. Using suspension HEK293 cells, rVSV-based vectors are currently only produced in batch mode. However, the establishment of perfusion cultivations at […]