Les maladies transmises par les tiques (MTT), comme la maladie de Lyme et l’anaplasmose, représentent un fardeau sanitaire en constante croissance au Québec et au Canada. Cette croissance est notamment liée aux changements climatiques et environnementaux modifiant la distribution des tiques à pattes noires. Ce sont les micromammifères qui sont responsables du maintien et de […]

Palladium-catalyzed cross coupling is one of the most powerful tools in modern synthetic chemistry, with is collaborative discovery recognised with the 2010 Nobel Prize for Chemistry. This class of reactions has had a huge impact on the way in which chemists think about building fine chemicals, because it allows for clipping of two molecules together […]

This project aims to explore ideas from a machine learning technique called Fibered AutoEncoders (FAE) for molecular representation learning. This technique will allow us to perceive the molecular space through a topological lens using the concept of fiber bundles, and it will give us a disentangled multi-level encoding of molecules. Since the molecular space is […]

Pleasant aromas fill our homes and enrich our lives, whether it’s by helping us relax after a long day’s work or evoking some of our fondest memories. This project will test scented fabrics prepared by Aroma Textiles Lab for their ability to inhibit the growth of the bacteria that are commonly found on our skin […]

Vector potentiator (VEPOs) are compounds that can enhance the ability of cancer-killing viruses to replicate and kill cancer cells. However, administering these compounds can be problematic as they are inherently toxic. To remedy this problem, we will link these compounds to a highly specific antibody, Trastuzumab, forming a new antibody-drug conjugate compound, T-VEPO. By means […]

Market approval of generic products requires that such products are shown to have equivalent safety and efficacy as the innovator product currently on the market. In general, generic topical dermatological products require comparative clinical trials in patients which require a large number of patients, are expensive and lengthy. This has led to a shortage of […]

A foundation model (FM) is any model that is trained at scale on a broad dataset and can be adapted (e.g., fine-tuned) to a wide range of downstream tasks; current examples include BERT, CLIP and GPT-3. In this project, we investigate the challenges of building foundational models for drug discovery: capturing multi-modal information, explainability, and […]

Although most cannabis use is recreational, cannabis is approved for various medical indications. One of most major safety concerns regarding the use of cannabis is its association with mental illness, in particular, induction or exacerbation of psychosis and schizophrenia, suicidal attempts and depression. That said, current available data in the field is based mostly upon […]

L’arthrose est le type d’arthrite le plus courant et une cause importante d’invalidité dans le monde. Avec une population canadienne croissante et vieillissante, la prévalence et le fardeau de l’incapacité devraient augmenter. Heureusement, le risque de développer de l’arthrose peut être réduit et bien qu’il n’y ait pas de remède connu, beaucoup peut être fait […]

Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD). Although its prevalence is rapidly rising worldwide, the pathophysiology and definite treatment of IBD is yet unknown. In particular, Canada is among countries with the highest IBD prevalence. Recently, circadian rhythm disruption has received significant interest for the IBD pathophysiology. In addition IBD patients […]

La sertraline est un médicament fréquemment utilisé dans la période postnatale afin de traiter la dépression. Cependant, il existe peu de données sur le passage de ce médicament dans le lait maternel et sur ses effets sur les enfants allaités. Une étude clinique est présentement en cours afin de quantifier la sertraline dans le lait […]

Des millions de Canadiens peuvent souffrir d’infections microbiennes au niveau des dents. Notre recherche vise le développement d’une nouvelle façon de traiter ces infections. Nous étudierons l’efficacité d’un produit nommé la dermaseptine à réduire la croissance des bactéries responsables des infections au niveau de la bouche et des dents. Si ce produit est efficace contre […]