En raison de la présence de la Barrière Hémato-Encéphalique (BHE), le cerveau est considéré comme l’un des organes les plus difficiles à cibler pour une action pharmacologique. Les pathogènes neurotropes, en revanche, ont été démontrés capables de traverser cette barrière et d’infecter les tissus cérébraux à travers l’endothélium microvasculaire cérébral. Ce projet repose sur l’hypothèse […]

Pseudomonas aeruginosa is a common cause of infection in cystic fibrosis patients globally. However, the growing antibiotic resistance and the high cost of developing new antimicrobials emphasize the need for alternative approaches. While macrolide therapy has shown benefits, resistance to this treatment is on the rise, indicating the necessity for new agents. Plant-based compounds (PBCs), […]

Ever-increasing complexity of high morbidity rate diseases including infections, cancer, atherosclerosis, has posed significant challenges in delivering active pharmaceutical agents at their intended targets. Polymeric soft nanoparticles based therapeutics have provided an advantageous platform, and have provoked the design of tailor-made nanoarchitectures that can load, target and deliver with high efficiency. Using synthetically articulated stimuli […]

The general objective of this project is to identify unbiased and objective plasma metabolomics signatures of milk and cheese consumption. We will leverage data and stored, unthawed, plasma samples from 4 high quality randomized, crossover, feeding trials (RCTs) and 1 cohort of 200 free-living adults (eMECA) that were conducted or implemented at INAF research center […]

Le Canada offre de soins de santé universel. Cependant, son système de couverture des médicaments d’ordonnance est très fragmenté. Cette fragmentation, accompagnée des coûts grimpant des médicaments, mène plusieurs canadiens à ne pas avoir les ressources nécessaires pour obtenir les médicaments dont ils ont besoin. L’idée d’un formulaire national émerge donc. C’est alors en février […]

The proposed research aims to exploit specific applications of epimeric pyrroloimidazolones (EPIs) for the synthesis of new drug leads. Two classes of biologically active molecules will be targeted. First, EPIs will serves as intermediates toward chiral bicyclic[2.2.2]octenes with nitrogen at the bridgehead position, which are known to have a broad range of biological activities. Second, […]

Many liver cancer cases are diagnosed at advanced and inoperable stages, at this point, the disease is highly lethal and most patients do not survive more than a year. Currently, the front-line treatment for inoperable liver cancer is antibody-based immunotherapy, but only 30% of patients respond to this therapy. Our lab has developed a lipid […]

We will study the efforts of traditional physicians to preserve their Indigenous healing system against the oppressive forces of western colonialism. Ayurveda is one of the oldest holistic healing systems in the world and has been practiced in India for more than 2,000 years. However, under the British rule and the spread of colonial medicine […]

The objective of this research program is the development of new green synthetic methods with emphasis on metal-free procedures for the simple preparation of biologically and commercially important molecules. In particular, fluorinated sp3-enriched Nitrogen-containing compounds will be prepared by radical reactions of redox-active esters (i.e., N-hydroxyphthalimide, N-hydroxy-2-thiopyridone, etc.) derived from fluorinated alicyclic carboxylic acids with […]

Crystal shape and size are among the most important features of crystalline product that are prevalent in the pharmaceutical industry. Extremely fine and needle-like crystals pose various problems in the downstream processes including filtration, tableting, handling, and storage. Rufinamide is an anticonvulsant medication, and its most stable and therapeutically advantageous crystalline form shows notoriously undesirable […]

Le cancer du sein triple négatif (CSTN) est un sous-type très hétérogène de cancer du sein qui présente un mauvais pronostique pour les patientes. En plus de présenter des taux élevés de chimiorésistance, l’importante hétérogénéité intra-tumorale du CSTN complique grandement le traitement des patientes. La progression tumorale est caractérisée par la régulation réciproque des reprogrammations […]

Alkynamides are very promising inhibitors of tyrosine kinases, important enzymes that can cause cancer when being too active in cells due to different mutations. While being important moieties, until recently there was no convenient method to synthesize them using carbamoyl fluorides — most protocols use either dangerous or expensive and ecologically unfriendly reagents, which always […]