The major problem with intervention for schizophrenia is the inability to treat all symptom categories (positive, negative, and cognitive) sufficiently. The need to test new novel therapies is crucial, which may prevent the onset of this debilitating disorder. Since intervention is limited to individuals at high risk, researchers have turned to animal models to test […]

ace à la propagation alarmante des bactéries résistantes aux antibiotiques, le développement de nouveaux antimicrobiens avec des modes d’action innovateurs est devenu une priorité mondiale. Parmi les différentes alternatives, les peptides antimicrobiens d’origine bactérienne comme les bactériocines sont très prometteurs. Ce projet s’intéresse particulièrement à cinq bactériocines produites par la bactérie Lacticaseibacillus paracasei qui ont […]

The emergence and spread of antibiotic resistant bacteria is a major threat to our ability to treat bacterial infections. The beta-lactams, a group that includes the penicillins, are a widely used group of antibiotics. However, bacteria can become resistant to beta-lactams by producing beta-lactamases, enzymes that inactivate these antibiotics. There has been great success in […]

This project aims to develop a novel therapeutic drug aimed at revolutionizing the treatment of severe cardiovascular diseases (CVD) and sepsis. Our project focuses on the modification of the ADAMTS13 protein, an enzyme that plays a crucial role in the blood clotting process. In patients with severe CVD or sepsis, ADAMTS13 is rapidly degraded, leading […]

In this project, the team will build a strong business foundation for a startup vehicle ‘Neuropeutics Inc’ to conduct further R&D and commercialize a new effective treatment for neurodegenerative diseases, namely ALS and FTD. That is, the team will develop a sustainable business model, a financial budget, a funds raising plan and marketing material. The […]

NorthMiRs is developing nanotechnology-enabled gene therapies for the treatment of sepsis. We have determined microRNAs that are dysregulated in septic patients and packaged them into a stable, synthetic, and scalable lipid nanoparticle delivery vehicle. Our lead therapeutic, NM-001, a miRNA replacement therapy for sepsis-associated cardiomyopathy has been shown to be anti-inflammatory, anti-microbial and protects organs […]

Interstitial cystitis is a life-long condition that causes pain and pressure in the bladder. It is not clear how this condition is caused; however, we know that it involves increased bladder inflammation. Currently available treatments for interstitial cystitis do not work for everyone and often stop working after a few years. We are developing a […]

Our proposed research project aims to answer the overall question: how do new arthritis medications taken during pregnancy affect mothers and their children? Many types of arthritis strike in females during their childbearing years. Even though we now know more about the effects of arthritis drugs when taken during pregnancy, the picture is not yet […]

Vaccination is an important preventive measure against influenza infection during both seasonal epidemics and pandemic outbreaks. This research aims to understand the effect of early vaccination during influenza outbreaks. The objectives are to measure the effectiveness of early vaccination in terms of reducing disease burden (e.g., infection, hospitalization). We apply an important methodology, namely mathematical […]

L’hydroxyurée est un médicament utilisé pour prévenir les complications de l’anémie falciforme ainsi qu’en chimiothérapie d’appoint pour certaines leucémies. En pédiatrie, l’hydroxyurée doit toutefois être ajustée selon le poids de l’enfant, ses prises de sang et la toxicité perçue. Or, au Canada, seule la formulation de 500 milligrammes est disponible. Ainsi, nos hôpitaux et nos […]

Our proposed research project aims to answer the overall question: what is the actual risk of infections or cardiovascular events for patients with inflammatory arthritis that take novel arthritis medication (biologics) and how does it compare between different classes of these drugs, in real-world settings? As well as asking if the safety and effectiveness of […]

Deamination of cytosine (C) and 5-methylcytosine (5mC) lead to GC to AT point mutations, which represent the major fraction of spontaneous mutations in a variety of genomes. We propose that most GC to AT mutations arise from the initial oxidation of C and 5C by reactive oxygen species followed by deamination of the intrinsic exocyclic […]