La psychiatrie est la branche de la médecine qui a le moins bénéficié des avancées majeures en biologie au cours du dernier siècle. Aujourd’hui, les diagnostics reposent encore uniquement sur l’observation des symptômes cliniques, souvent communs à plusieurs troubles. Dans le cas de la bipolarité, il faut en moyenne 5 à 10 ans pour établir […]

Nous proposons une solution innovante et respectueuse de l’environnement pour produire du Cannabidiol (CBD), une molécule reconnue pour ses nombreuses applications thérapeutiques. Aujourd’hui, la production de CBD repose principalement sur la culture de la plante de cannabis et sur des procédés d’extraction chimique, des méthodes coûteuses, gourmandes en ressources naturelles et parfois polluantes. Grâce à […]

Leveraging large-scale genetic data for identifying novel therapeutic targets. Developing a new drug takes an average of twelve years and costs over a billion dollars. This exorbitant cost is largely due to the high failure rate in drug development. In fact, more than 90% of drugs tested in humans will never reach the market. In […]

We are developing a library/biobank of in vitro 3D bioprinted living tumor models to accelerate cancer drug development and bridge the translational gap. By incorporating human cells into organ-specific proprietary 3D bioprintable hydrogels we replicate the biochemical and physical properties of the tumor microenvironment with a high degree of complexity using only bio-derived materials. By […]

Hemophilia is a rare blood coagulation disorder caused by a deficiency or deformity in one of 12 primary clotting factors. Hemophiliacs experience insufficient healing and prolonged bleeding either from trauma or unprompted bleeding. We are able to maintain a level of the deficient factors in a patient through direct and immediate infusion of a drug […]

The purpose of the project is to design a paper-based device for the co-detection of nitric oxide (NO) and glucose in a tumor angiogenesis model. By combining paper technologies to electrochemical sensing, we envision that an easy-to-use, smart tumor model can be built. The devices will be tested on co-cultured endothelial and tumor cells, to […]

Devant le nombre grandissant d’études sur l’effet des médicaments pris pendant la grossesse, les chercheurs et cliniciens sont confrontés à une multitude de résultats, parfois contradictoires. Les méta-analyses peuvent aider à évaluer la qualité et à synthétiser ces études. Les résultats des méta-analyses peuvent toutefois être biaisés par le biais de publication, qui survient lorsque […]

With an aging population, age-related neurological disorders like Alzheimer’s and Parkinson’s diseases, as well as stroke, are increasing. These conditions involve critical neuron loss, yet the brain’s ability to replace neurons is highly limited. Current regenerative therapies, such as neural stem cell stimulation or neuron transplants, show promise but face challenges in manufacturing and patient […]

The hydroxy group (–OH) is well represented in organic chemistry and is present in 37% of commercial therapeutics, 69% of natural products and numerous biomasses. Despite their ubiquitous nature, the development of methods to directly transform hydroxy groups in a mild and less wasteful way has been seriously neglected. This, therefore, pushes for a method […]

More than 25 million Africans and 800,000 Canadians suffer from chronic wounds. Wound infections are a leading cause of hospitalization and disability in immunocompromised people and vulnerable populations. This is compounded by the indiscriminate use of antibiotics, leading to antimicrobial resistance and failure of treatments. Therefore, antibiotic alternatives are needed. Inspired by traditional wisdom, phytotherapy […]

Kaposi sarcoma-associated herpesvirus (KSHV) is virus, whose unabated lifecycle results in the formation of cancerous tumorous. Moreover, KSHV infection is particularly prevalent in people living with HIV, and has a disproportionate burden in sub-Saharan Africa. Despite this clear unmet medical need, there are no approved treatments for KSHV. Recent work, conducted in South Africa has […]

The project was initiated to tackle the public health crisis posed by the emergence of multidrug-resistant tuberculosis (MDR-TB), which is more challenging to treat than drug-sensitive TB and typically requires longer treatment regimens (i.e., > 18 months). Treating MDR-TB involves daily medication usage (either as oral tablets, capsules, liquids or injections) making adherence to treatment […]