Le marché mondial des médicaments biosimilaires est en pleine expansion. Le développement des biosimilaires constitue un enjeu majeur à la fois d’un point de vue économique et d’un point de vue sanitaire. Dans le contexte d’une population vieillissante, d’une augmentation des maladies chroniques et d’un budget de plus en plus contraint, les biosimilaires pourraient permettre […]

For platelet transfusion, it is necessary to prepare, store and maintain platelet concentrates. Platelets concentrates have a short shelf life and must be conserved at ambient temperature – ideal for bacterial growth. Bacterial contamination of platelet concentrates represents the major cause of morbidity and mortality in transfusion. However, the bacterial agent causing these effects remains […]

The therapeutic effect of a vaccine depends on its chemical composition, and in particular the integrity of its protein components. Conditions under which a vaccine is manufactured and stored can damage the proteins it contains; however, since proteins are structurally complex and reactive, their degradation during routine handling is unpredictable. In the project described here, […]

Ginseng is a medicinal plant with a long history of traditional use. The medicinal properties of ginseng root have been attributed to two main classes of chemical compounds: ginsenosides and polysaccharides. While much is known about ginsenoside pharmacology, less is known about polysaccharide pharmacology. One of the most important properties of ginseng root polysaccharides is […]

Pertussis, caused by the strict human pathogen B. pertussis or Bordetella parapertussis, is a highly contagious, potentially life-threatening respiratory tract illness when it occurs in unprotected infants. Despite the introduction of acellular pertussis (aP) vaccines and great initial success of the immunization program, pertussis outbreaks were reported in adolescents and adults in Canada since 1993. […]

Cancer is a complex disease that involves multiple changes in normal cell biology, all of them leading to increased and abnormal cell replication. Depending on the tissue type, this uncontrolled tissue growth ultimately causes organ malfunction and a wide variety of signs and symptoms which, all together, indicate a pathological state which needs to be […]

This research collaboration explores the application of Chan-Lam coupling (expertise of the Schaper group) in mechanochemistry (expertise of the Jurca group) to explore new and more efficient preparation methods in drug development and production.

This project proposes a scalable quantum-enhanced generative model for drug discovery, targeting the design of KRAS inhibitors through the integration of Neural Quantum States (NQS), Quantum Circuit Born Machines (QCBMs), and CUDA Quantum acceleration. By replacing traditional quantum circuits with adaptive NQS representations and extending QCBM capacity to 32 qubits, the framework enables more expressive […]

The mission of PI16 Therapeutics is to improve skin health for the ~4 million Canadian’s suffering from long-term skin diseases, including clinically dry skin, chronic wounds, and severe burns. PI16 Therapeutics aims to produce skin solutions for these individuals by genetically engineering naturally occurring stem-cell like fibroblasts that express the gene Peptidase Inhibitor 16 (Pi16) […]

Ce projet vise à transformer une découverte scientifique prometteuse en une entreprise biotechnologique dédiée au développement d’un traitement innovant contre la sclérose latérale amyotrophique (SLA), une maladie neurodégénérative incurable. Issu du laboratoire du Dr Alex Parker au CRCHUM, le traitement proposé repose sur un mécanisme inédit de régénération des neurones endommagés. Les traitements actuellement disponibles […]

This project will support the development of DeepScript, a software platform that helps researchers find promising small molecules for drug discovery without needing to run large and expensive screening campaigns. Instead of testing hundreds of thousands of compounds, DeepScript uses biological data and artificial intelligence to predict which existing compounds are most likely to work […]

mTatt is a medtech startup developing functional microtattoos for real-time, at-home health monitoring. Using dissolving microneedles — biocompatible structures under 1 mm in length — we painlessly deliver fluorescent sensors into the skin, creating a functional tattoo. These sensors respond to key biomarkers like NT-proBNP, glucose, or electrolytes, providing clinically valuable insights without blood draws […]