Biomolecular Quantitation and Structure Analysis to Accelerate Development of New Vaccines

Manufacturing of consistently high quality products is the commitment of the pharmaceutical industry. To achieve this, new products must be thoroughly tested and the results meet government-approved product specifications. Improving existing and adopting improved analytical technologies for product testing ensure the production of safe and effective products. This is particularly critical for the manufacturing of […]

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Oncolytic HSV-1 (oHSV-1) for Treatment of Urologic Cancer

This project is to use genetic engineered “cold-sore” virus to treat prostate cancer. The virus is engineered to reduce its toxicity to normal tissues but can specifically attack and kill tumour cells. Meanwhile, the virus releases a group of anti-tumour immune stimulating factors to activate immune system to eliminate prostate tumour. This project will use […]

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Optimization and compatibility study of a pH-responsive terpolymercomposite membrane for controlled release dosage forms

A new film coating that can respond appropriately to different pH conditions of the stomach and small intestine (GI tract) was successfully prepared by combining pH-responsive nanoparticles with ethylcellulose polymer. However, the performance of the composite membrane has not been optimized for controlling drug release in the GI tract. Therefore, improvements are to be made […]

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Monodisperse PhytoSpherix Nanoparticles Modified for Key Applications in Personal Care, Food and Nutraceuticals – Year two

Our previous work has shown the promise of monodisperse phytoglycogen for many applications. However, these experiments only scratch the surface of potential uses since the chemistry of the particles (as extracted) is fixed. Nanoparticles offer very high surface areas, and glucose units are easily modifiable, thus there exist a multitude of ways to chemically modify […]

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Monodisperse PhytoSpherix Nanoparticles Modified for Key Applications in Personal Care, Food and Nutraceuticals

Our previous work has shown the promise of monodisperse phytoglycogen for many applications. However, these experiments only scratch the surface of potential uses since the chemistry of the particles (as extracted) is fixed. Nanoparticles offer very high surface areas, and glucose units are easily modifiable, thus there exist a multitude of ways to chemically modify […]

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Immune modulation with checkpoint inhibitor antibodies targeting GITR or OX40 to improve cancer immune therapy with DepoVaxTM vaccine and metronomic cyclophosphamide

Immunovaccine Inc. is developing immune therapies for cancer using the company’s DepoVaxTM vaccine technology. DepoVax is a patented formulation provides controlled and prolonged exposure of antigens and adjuvants to the immune system, resulting in a strong, specific and sustained immune response. Immunovaccine’s translational research team is focused on improving responses in advanced cancers by combining […]

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Enteroids and enteroid derived monolayer cultures: Using primary intestinal epithelial cell cultures to define the mechanisms underlying epithelial intrinsic innate defenses

Using growth media available from Stemcell technologies, along with our own tools and techniques, we can isolate and grow intestinal stem cells from mice or human patient donors into enteroid cultures. Enteroids are 3D cell cultures that replicate many of the structures and types of cells found in the intestinal lining. We propose to work […]

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Biomolecular Structure Analysis to Accelerate Develoment of New Vaccines and Monoclonal Antibodies

Manufacturing of consistently high quality products is the commitment of the pharmaceutical industry. To achieve this, new products must be thoroughly tested and the results meet government-approved product specifications. Improving existing and adopting improved analytical technologies for product testing ensure the production of safe and effective products. This is particularly critical for the manufacturing of […]

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Implication de nouveaux produits biologiques sur la réponse du stress au réticulum endoplasmique chez les cellules myéloïdes humaines

Ce projet vise à élucider davantage le mode d’action de certains produits élaborés par ProMetic BioSciences inc. sur certaines cellules myéloïdes humaines en relation avec une réponse cellulaire impliquée dans un nombre grandissant de maladies humaines. Il s’agit d’un stress du réticulum endoplasmique (RE), un organite cellulaire impliqué dans la synthèse des protéines. Cette dernière […]

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Implication de nouveaux produits biologiques sur la réponse du stress au réticulum endoplasmique chez les cellules myéloïdes humaines – Year Two

Ce projet vise à élucider davantage le mode d’action de certains produits élaborés par ProMetic BioSciences inc. sur certaines cellules myéloïdes humaines en relation avec une réponse cellulaire impliquée dans un nombre grandissant de maladies humaines. Il s’agit d’un stress du réticulum endoplasmique (RE), un organite cellulaire impliqué dans la synthèse des protéines. Cette dernière […]

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