Receptor proteins are important for therapeutics, medicines, diagnostics and biomanufacturing. Generating new proteins is incredibly difficult however machine learning techniques have been developed to assist in evolving proteins. Using these techniques, I plan to create receptor mimics that are smaller and have improved properties. These will benefit many industries such as therapeutics, medicines, diagnostics and […]

G-quadruplex (G4) are a type of DNA or RNA that can fold into different types of structures, where four guanine bases are held together by Hoosteen hydrogen bonds. The type of structure that forms plays a key role in genomic events that can affect telomerase activity. Unregulated, telomerase can cause tumour formation, and in some […]

Herein, we propose the lead optimization of novel antitubercular quinolone compounds targeting the DprE1 enzyme; an important enzyme in Mtb cell wall biosynthesis. The previously synthesised compounds exhibited sub-micromolar activity against the wild type (H37Rv) Mycobacterium (Mtb) strain. The lead compound in the series further exhibited activity against resistant fluoroquinolone Mtb strains and it binding […]

Antenatal corticosteroids are life-saving drugs administered to pregnant people at risk of imminent preterm birth. As the usage of these drugs continues to expand, select studies have raised concerns about potential longer-term consequences among infants born many weeks after treatment. Yet, because the exact timing of birth is unpredictable when treatment is administered, the causal […]

The test-negative design (TND) is an observational study design that is currently and routinely being used globally to evaluate the effectiveness of vaccines against COVID-19 illness caused by emerging SARS-CoV-2 variants. Recently, more reliable statistical estimators were proposed to get better estimates of vaccine effectiveness. However, no one has yet investigated what statistical methods will […]

Violacein is a molecule naturally produced in some bacteria such as Chromobacterium violaceum. It has been shown that violacein has promising antibiotic, anti-tumor proliferation, anti-leishmanial and anti-fungal properties. Violacein is commercially available. However, it is very expensive. The objective of this proposed research study is to measure the effects of violacein produced by Escherichia coli […]

C-Myc, N-Myc and L-Myc were shown to have a partially redundant function in cells. Since their identification, extensive efforts were made to characterize their respective function at homeostasis and their role in various infamous diseases. Still, very little is known about those proteins at a biophysical level, except for c-MYC. Interestingly, despite being critical for […]

Nearly 90% of drug candidates fail during the drug design and development process, resulting in exorbitant costs to bring a new drug to market. Our technology, LigandQI, addresses the critical shortcomings in current computational drug design programs by leveraging ab initio quantum chemistry to quantify ligand-receptor interactions with unprecedented accuracy. Unlike traditional methods, our program […]

While eye drops are the most common treatment for anterior segment ocular disorders, they are inefficient due to fast clearance, often requiring frequent and high doses, reducing patient compliance, and increasing the risk of systemic toxicity. To improve the efficiency and efficacy of topically applied therapeutics, a drug-loaded polymeric micelle that interacts with the mucin […]

Palladium-catalyzed cross coupling is one of the most powerful tools in modern synthetic chemistry, with is collaborative discovery recognised with the 2010 Nobel Prize for Chemistry. This class of reactions has had a huge impact on the way in which chemists think about building fine chemicals, because it allows for clipping of two molecules together […]

Vaccination is an important preventive measure against influenza infection during both seasonal epidemics and pandemic outbreaks. This research aims to evaluate the health benefits and costs associated with a new vaccine developed by Sanofi for seasonal influenza. This vaccine provides better efficacy and higher protection for individuals over 65 years of age. The vaccine is […]

Blue-O Technology Inc has developed proprietary samples that have demonstrated antiviral activity against HIV-1 and influenza. Blue-O Technology Inc has purified these proprietary samples to isolate different subunit components. These subunit components will be used by the intern determine which components have anti-HIV or anti-influenza activity. Initial experiments will be undertaken in cell culture systems […]