This research project, to be undertaken during a 4-month internship at Arizona State University, aims to develop an artificial chemistry system to investigate the influence of pore system topology on molecular complexity, using Assembly Theory as a measure. The project’s significance lies in its potential to enhance our understanding of Assembly Theory, with implications for […]

The proposed research project aims to analyze trends in psychopharmacology research, focusing on how different funding sources influence research topics. This analysis will help understand how the field has evolved over time and whether corporate interests dominate the research agenda. By conducting this study, the participating institutions will gain valuable insights into the current state […]

This project aims to develop a method for delivering reprogramming transcription factor genes to astrocytes in the central nervous system using Intelligent Phagemid-Assembled Gene Expression (iPhAGE) technology. By constructing specific gene blocks and fusion helper plasmids, synthesizing iPhAGE DNA, and purifying iPhAGE preparations, the project seeks to enhance transfection efficiency and assess immune responses and […]

Cyanobacterial and microalgal host cells produce a range of bioactive compounds that makes them good candidates for drug discovery. At the same time, they themselves get infected by a range of different viruses. This means that understanding the interplay of these hosts with the viruses that infect them is crucial in order to optimize bioactive […]

This project is dedicated to unveiling how proteins within cell membranes adapt to their surroundings, particularly the lipid environment. Employing computer simulations and machine learning (ML), we focus on RAS signaling proteins and Mga2 transcription factors. RAS proteins, crucial for cell growth and division, are anchored to the cellular membrane and often exhibit mutations in […]

Gene therapy has the potential to cure a wide range of debilitating genetic diseases. One of the best ways to correct a genetic defect is to use a viral vector to deliver a functional copy of the gene to cells in the body so that they can express a functional protein and reverse the disease […]

La sclérose en plaques est une maladie chronique qui atteint généralement les jeunes adultes. Elle est souvent associée à d’autres maladies chroniques telles que l’hypertension artérielle. Les patients ont donc tendance à consommer plusieurs médicaments pour traiter la sclérose en plaques et les autres maladies. Or, la consommation de plusieurs médicaments peut avoir des effets […]

The discovery of CRISPR-based gene therapy methods using viral vectors, and SARS-CoV-2 vaccines based on lipid nanoparticle formulations has revolutionized the field of personalized medicine, and promises revolutionary applications for curing cancer, genetic disorders, and other diseases on the molecular level. To facilitate the validation of new therapies, biopharma companies use analytical ultra-centrifugation (AUC) to […]

The proposed research aims to apply the capabilities of machine learning to study molecular models of cell membranes. Cell membranes are composed of fluid lipid bilayers with a highly dynamic nature. By developing neural network models for the simulation of lipid bilayers, we seek to overcome the shortcomings of current computational methods, providing superior accuracy […]

Treatments for neurodegenerative disorders represent an unmet medical need, affecting more than 50 million people worldwide. Through extensive research, we have identified two innovative therapeutic targets that have demonstrated promising effects in enhancing the regeneration and resilience capacities of neurons in animal models of Amyotrophic lateral sclerosis and Huntington’s disease. Our approach not only has […]

Le projet consiste à étudier de nouveaux complexes métalliques en particulier à base de Nickel afin de pouvoir les utiliser dans le cadre de réactions catalysées. Cette recherche a pour but le développement futur de processus plus efficaces, plus économiques et plus verts pour la production de produits organiques utiles à la société. Le palladium […]

Le projet de recherche concerne la mise au point de systèmes catalytiques efficaces, permettant des cyclisations et des fonctionalisations de molécules insaturées de type ène-ynes et aldéhyde-ynes. Ce projet proposera différentes facettes, la première étant la synthèse des précurseurs insaturés. Dans un second temps, es conditions réactionnelles seront étudiés et mises au point en modifiant […]