There is a growing body of evidence that certain combinations of bioactives derived from natural source products may have potent effect on neuritogenesis and foster neuronal cell viability. The effect of neuron plasticity suggests there are potential treatments of major neurodegenerative and psychiatric conditions. In this project we are proposing to use a robust in […]

Develop and design a fully automated and simple to operate amino acid analyzer capable of detecting with high degree of sensitivity the broadest range of amino acid metabolites or molecular structures found in living cells and chemical compounds. Analyzing the makeup of these structures is often the core to understanding the cause of human health […]

Effective anti-viral therapies are required to treat individuals infected by the SARS-Cov-2 virus, the causative agent of COVID-19. So far, only repurposed drugs have been investigated as treatment to fight SARS-Cov-2 infection. The goal of the project is to use our custom yeast-based screening platform in collaboration with the artificial intelligence algorithms of InVivo AI […]

La COVID-19 est causée par un nouveau virus, le SARS-CoV-2 et frappe durement la population mondiale. Cette maladie soulève de nombreuses questions, dont celle de savoir si l’immunité développée par les personnes ayant guéri de la maladie permet de neutraliser efficacement le virus et d’assurer une protection à long terme. Dans le cadre de ce […]

Sanofi Pasteur has established a cutting-edge facility for the production of different types of vaccines in Toronto. This state-of-the-art facility is comprised of various complex mixing operations, which play significant role in the vaccine production. Currently, there is lack of sufficient information about the hydrodynamics of these mixing units for the process validation. In this […]

The goal of this study will be to characterize a SARS-CoV2 antigen and the formulated drug product that will contain SARS-CoV2 antigen and a squalene-based adjuvant under tight timeline to release the material for COVID-19 vaccine clinical trials.

Our project aims to design and develop COVID19 vaccines engineered from viruses that infect bacterial cells only. SARS-CoV2 pathogenic components have been identified and modified to develop the vaccine. Although these components are pathogenic in nature, they are modified to pose no harm. The vaccine is designed to be administered intranasally, where it relocates to […]

Long QT Syndrome (LQTS) is a genetic disorder that causes prolongation of cardiac repolarization, observed as an elongation between the Q and T waves observed on an electrocardiogram. The lengthening of these waves can cause unexpected and life threatening arrhythmias. Current therapies for the LQTS are limited to ?-blockers and left cardiac sympathetic denervation which […]

The objective is to develop an in-line Process Analytical Technology (PAT) tool to monitor viability and biomass levels at the fermentation stage bacterial organisms. The Master student will be engaged in the development of the PAT tool for deployment into a state-of-the-art vaccine manufacturing facility. The student will use benchtop tools such as flow cytometry […]

The goal of the project is to facilitate the research and development of new drugs using machine learning. More specifically, exploring new techniques to model molecules and how they can be represented. Doing so will involve training deep learning models on multiple small datasets with the objective of improving the generalization performance on new tasks. […]

The objective of this internship is to create new chemical compounds that can be used to further our research and understanding of a human enzyme known as GBA2 – implicated in several debilitating diseases and signalling pathways in the body. These compounds would not only serve as tools to probe GBA2 for additional information but […]

Prostaglandin E2 stimulates bone formation in vivo and exerts its effects through the EP4 receptor. Unfortunately prostaglandin E2 and agonists for the EP4 receptor also cause unacceptable systemic side effects which have limited their clinical use as anabolic agents. We developed novel bone-targeting prodrugs that can deliver EP4 agonists selectively to bone and liberate active […]