Proteins are molecular machines that function inside cells to regulate processes such as cell growth, division and death. Protein function is modified by the attachment of regulatory proteins such as ubiquitin. Ubiquitin modification is important in targeting proteins for destruction in the cell during cell division. Dysregulation of protein destruction can lead to inappropriate cell […]

Static mixers are metal structures inserted into pipes to enhance the mixing of fluids flows. Different mixer designs cause different levels of mixing for a given energy loss. An ongoing and promising project is the invention of a new mixer geometry that is more efficient than anything on the market. Experimental testing uses the PLIF […]

le projet de recherche repose sur l’utilisation d’une approche complémentaire par phytothérapie afin de traiter le cancer buccal , limiter son évolution , améliorer sa prévention et la qualité de vie liée aux personnes qui en sont atteintes. l’étudiant aura pour tâche d’étudier l’effet anticancéreux de l’anéthol sur les cellules du cancer de la bouche […]

Le cancer est un problème de santé mondial et la deuxième cause de décès la plus courante chez les humains. Selon des statistiques récentes, il y avait plus de 18 millions de cas actifs de cancer responsables d’environ 9,6 millions de causes de mortalité. (OralcancerfoundationFacts) Selon la Fondation du cancer buccal, les tumeurs malignes de […]

The safety and quality of vaccine products are an integral requirement for all vaccine manufacturing and production. Most current tests are using laboratory equipment that requires trained personnel, equipment qualification, method validation, manual sampling, and testing at various stages of product manufacturing. However, the off-line testing is slow, often requires significant volume of material for […]

Most of the drugs used to treat cancer have been originally identified from natural sources. While Nature did a great job selecting those compounds, some of them have shown limitations in the treatment of cancer and others have shown to be insufficient on some cancer types. Furthermore, it exists a gigantic number (nearly infinite) of […]

Vaccine antigen production is a process that entails numerous variables. In order to have a consistent and robust process, monitoring of process parameters and controlling output variables within a certain range is the best practice. To accomplish this objective, analytical tools are used, on-line, off-line, at line. Real time monitoring of the processes is advantageous […]

La presente recherche traite de l’evaluation des risques faisant obstacle a la liberte d’exploitation (FTO) d’un produit biologique, tel que levaccin XX d’influenza developpe par Medicago®. Elle correspond a la derniere etape du systeme de controle P.I. et a, notamment, pour objet d’identifier de nouveaux risques, mais egalement de mettre a jour taus les risques […]

The central problem of pharmaceutical research is to understand the effect of a certain molecule on human or animal biology. Many machine learning models have been developed in recent years and show great efficiency and accuracy for this kind of predictions. However, a problem common to many of the best algorithms is that they require […]

Our DNA exists in many different forms. The G-quadruplex is a type of DNA structure made from four strands of DNA. These structures are highly stable and potentially form throughout the genome at clinically important sites. To understand how G-quadruplex structures form, we need to investigate the physical forces that hold the molecules together. When […]

La prescription de médicaments en pédiatrie et particulièrement en néonatologie est un versant délicat de la pratique quotidienne. En effet, les données sur la sécurité d’emploi et les effets de nombreux traitements utilisés chez le nouveau-né demeurent insuffisantes. Dû à l’absence d’alternative thérapeutique, la plupart des molécules sont utilisées en dehors de leur recommandation officielle […]

Aux Etats-Unis, plus de 15 millions d’unités de sang sont transfusées chaque année à des patients atteints, entre autres, d’anémies ou de certains cancers. Bien que cette technique soit pratiquée depuis longtemps, plusieurs risques y demeurent associés. Le risque le plus important est l’incompatibilité entre le donneur et le receveur, pouvant résulter dans les cas […]