The overall goal of our work is to use novel genetically modified rodent models to determine how two gene regulatory proteins known as ‘TIPARP’ and ‘AHR’ interact to influence mammalian responses to an important class of chemical toxicants that are found in certain foods and in the environment. These include the potential pesticide contaminant dioxin […]

As diabetes continues to rise globally, the risk of developing chronic diabetic complications greatly increases. Among these complications, non-alcoholic fatty liver disease (NAFLD) is a serious liver disease that can contribute to major scarring of the liver and this may ultimately lead to liver failure. To develop a better understanding of the processes involved in […]

In January 2018 the Australian Department of Home Affairs introduced several changes to the visiting rules for immigration detention centeres on Australia’s mainland. These changes significantly restricted access to refugees detained in such facilities. Throughout 2018 Dr. Nethery from Deakin University in Australia conducted a series of interviews with visitors to such immigration detention centres […]

Fatty liver disease occurs in the setting of obesity and a high-fat diet, and involves a build-up of excess fat in the liver. Excess fat can cause injury to the liver, which can lead to scarring, and in some cases liver cirrhosis and cancer. As obesity rates increase, it is important to investigate possible ways […]

The objective of my research in the Fillingham Lab at Ryerson University is to understand how genes works since it is a fundamental process and its failure is implicated in many diseases. Understanding how genes works has shown to have promising outcomes in the treatment of many diseases since this research can reveal novel drug […]

Solids exist as crystals, amorphous or subcooled liquids. The degree of crystallinity determines the long range order in a solid phase. Molecules when transferred from the solution to the solid phase may take many different crystal forms (polymorphs, solvates/hydrates, salts, co-crystals). Theoretically, there are 230 space groups describing the diversity of a crystalline material. About […]

Enzymes are important biological catalysts which span all domains of life. They play vital roles in the metabolism and production of biomolecules in different organs. Our interest lies in using enzymes to develop biosensors to be employed in studying neurochemical processes occurring in the brain. The purpose of this project is express and characterize three […]

Ovarian cancer (OVCA) causes more death than any female cancer in the world. Although patients respond to treatment initially, 70% of them relapse and do not succumb to treatment. Up-to-date, there is no established treatment for such patients. There is therefore the need to investigate the tumor microenvironment for novel targets to enhance treatment. Although […]

The Rett syndrome is a progressive neurodevelopmental disorder and one of the most common causes of mental retardation in females. Because males have a different chromosome combination from females, most males with Rett syndrome die before birth or in early infancy. It was not until 1999 that it was discovered that the Rett syndrome is […]

Better understanding Drug-Drug interactions (DDIs) is crucial for planning therapies and drugs co-administration. While, considerable efforts are spent in labor-intensive in vivo experiments and time-consuming clinical trials, understanding the pharmacological implications and adverse side-effects for some drug combinations is challenging. The majority of interactions remains undetected until therapies are prescribed to patients. We propose to […]

Il a été démontré que les tumeurs exploitent certains mécanismes liés aux récepteurs immunitaires (point de contrôle) pour échapper à la réponse immunitaire. La mise sur le marché d’anticorps monoclonaux (mAbs) approuvés par la FDA, pembrolizumab et nivolumab en tant qu’inhibiteurs du récepteur immunitaire programmed death-1 (PD-1), et du durvalumab et de l’avelumab qui ciblent […]

In this Mitacs project, we examine how nascent technology advocators can successfully implement the technology in highly institutionalized settings. Using the implementation of Blockchain in healthcare data sharing as an example, we compare and contrast the implementation strategies of 6-8 start-ups or divisions of established companies, and examine how the different types of implementation strategies […]