Innovative Projects Realized

Characterization of molecular pathways mediating the effects of novel therapeutic agents in heart failure

Heart failure (HF) is a condition that develops after the heart becomes damaged or weakened. HF occurs when the pumping action of the heart is not strong enough to move blood around, especially during increased activity or under stress. In addition, the heart muscle may not relax properly to accommodate the flow of blood back from the lungs to the heart. These abnormalities in heart function can cause fluid to back up in lungs and in other parts of body. More than 30% of subjects with HF develop pulmonary hypertension (PH); a condition associated with a poor quality of life and reduced survival. PH associated with left heart disease (LHD), classified as group II PH, is most common in patients with HF: those with HF with preserved ejection fraction (HFpEF) and those with reduced ejection fraction (HFrEF).There is however currently no therapy that can selectively target the molecular processes responsible for PH due to LHD and these subjects still unfortunately progress to right ventricular failure and death. PBI-4050 and PBI-4547 are a novel therapeutic agents developed by ProMetic targeting an orphan receptor that is highly expressed in lung tissues of animals with HF. TO BE CONT.

Robot Programming for a Modular, Reconfigurable Handling System

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Graphene assembly in nano-structured block copolymer thin films

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Impact of environmental pollutants on obesity development in infants

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P2Y1 Receptor Agonists as New Potential Treatment for Type 2 Diabetes

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Elucidating novel protein interactions in yeast models for motor neuron diseases

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Clickable anti-fouling hydrogel coatings for filtration membranes

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Virtual testing platform for design and optimization of cantilever-typesensors

Using a multiphysics approach, the intern will construct a model for the topological optimization of

two distinct classes of cantilever-type sensors: one often encountered in the general industrial

application and the other one customized for the specific needs of a biosensor. Altair Hyperworks will

be the main software tool to be used for this particular type of optimization and the aforementioned

type of sensors will be modeled and their behavior simulated in complex multiphysics conditions.

These results will generate a software platform useful for testing several types of sensors (materialwise

and class-wise) under diverse loading conditions (force, temperature, pressure, humidity) and will

help the sponsor company in generating a portfolio on the niche of the market requesting such type of

numeric modeling and simulation. On the same time, the results are of great value for the biological

sensor developed by the intern in order to obtain his PhD degree. The student will benefit from the

interaction with the company’s …

Automatic Synthesis of Controllers for Reactive Systems

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People as ?intuitive retributivists?? Not exactly! Situational influences shape punishment goals

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Plant movements as inspiration for adaptive kinetic architecture

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Sustainability Assessment of Production Strategies

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